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• W4281763001 startingPage "4576" @default.
• W4281763001 abstract "Skin wounds and their related bacterial infections are one of the issues that would seriously threaten public health. Wound dressings affording antibiofouling capability and incorporating antimicrobial agents could prevent infection and favor wound healing, which have significant clinical demands and value. Antibacterial photodynamic therapy (aPDT) induces toxic singlet oxygen to kill microbes through a photodynamic pathway that avoid the development of drug-resistant microbes. In this study, coaxial electrospinning technology was employed to fabricate an antibacterial wound dressing containing thermoplastic polyurethane (TPU) as the core and zwitterionic and cross-linkable polysulfobetaine copolymer as the sheath. The prepared nanofibrous membranes exhibited good water uptake and retention capability, excellent in vitro biocompatibility and antifouling performance. The elastic properties of TPU improved the stretching and mechanical performance of the membranes that mimic the extensibility of the human skin. Moreover, methylene blue-loaded nanofibrous membranes have shown good antibacterial photodynamic inactivation against Gram-positiveStaphylococcus aureus (99.875%, 2.90 log units inactivation) and Gram-negative Escherichia coli (99.705%, 2.53 log units inactivation) upon mild light irradiation (500 W m–2), while as expected, E. coli cells have shown lower susceptibility to aPDT. Overall, the zwitterionic core-sheath nanofibrous membranes with aPDT function are potentially used as a promising antibacterial wound dressing." @default.
• W4281763001 created "2022-06-13" @default.
• W4281763001 creator A5037630733 @default.
• W4281763001 creator A5063513181 @default.
• W4281763001 date "2022-06-01" @default.
• W4281763001 modified "2023-10-18" @default.
• W4281763001 title "Zwitterionic Core-Sheath Nanofibers in Antibacterial Photodynamic Therapy" @default.
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• W4281763001 doi "https://doi.org/10.1021/acsapm.2c00585" @default.
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