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- W4281763444 abstract "Semaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved for treatment of type 2 diabetes mellitus and is available in subcutaneous and oral dosage form. Diabetes, insulin resistance, and obesity are responsible for the pathological manifestations of non-alcoholic steatohepatitis (NASH). Similarly, insulin resistance in brain is also responsible for neurodegeneration and impaired cognitive functions.Observations from phase-3 clinical trials like SUSTAIN and PIONEER indicated anti-obesity potential of semaglutide, which was established in STEP trials. Various pre-clinical and phase-2 studies have indicated the therapeutic potential of semaglutide in non-alcoholic steatohepatitis and neurodegenerative disorders like Parkinson's and Alzheimer's disease.Significant weight reduction ability of semaglutide has been demonstrated in various phase-3 clinical trials, for which recently semaglutide became the first long-acting GLP-1 receptor agonist to be approved by the United States Food and Drug Administration for management of obesity. Various pre-clinical and clinical studies have revealed the hepatoprotective effect of semaglutide in NASH and neuroprotective effect in Parkinson's and Alzheimer's disease.Many GLP-1 receptor agonists have shown hepatoprotective and neuroprotective activity in animal and human trials. As semaglutide is an already clinically approved drug, successful human trials would hasten its inclusion into therapeutic treatment of NASH and neurodegenerative diseases. Semaglutide improves insulin resistance, insulin signalling pathway, and reduce body weight which are responsible for prevention or progression of NASH and neurodegenerative diseases." @default.
- W4281763444 created "2022-06-13" @default.
- W4281763444 creator A5039907323 @default.
- W4281763444 creator A5061471517 @default.
- W4281763444 creator A5079133716 @default.
- W4281763444 date "2022-06-01" @default.
- W4281763444 modified "2023-10-11" @default.
- W4281763444 title "Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review" @default.
- W4281763444 cites W1784370615 @default.
- W4281763444 cites W1968002849 @default.
- W4281763444 cites W1972703677 @default.
- W4281763444 cites W1976844911 @default.
- W4281763444 cites W1992116679 @default.
- W4281763444 cites W2000054651 @default.
- W4281763444 cites W2003982930 @default.
- W4281763444 cites W2013082477 @default.
- W4281763444 cites W2014156217 @default.
- W4281763444 cites W2017810555 @default.
- W4281763444 cites W2036469377 @default.
- W4281763444 cites W2039827979 @default.
- W4281763444 cites W2043246453 @default.
- W4281763444 cites W2047324057 @default.
- W4281763444 cites W2054088567 @default.
- W4281763444 cites W2060936747 @default.
- W4281763444 cites W2064329557 @default.
- W4281763444 cites W2088666203 @default.
- W4281763444 cites W2107440671 @default.
- W4281763444 cites W2115505876 @default.
- W4281763444 cites W2130428892 @default.
- W4281763444 cites W2137937034 @default.
- W4281763444 cites W2141915016 @default.
- W4281763444 cites W2156339883 @default.
- W4281763444 cites W2161883681 @default.
- W4281763444 cites W2180065345 @default.
- W4281763444 cites W2334243568 @default.
- W4281763444 cites W2516535870 @default.
- W4281763444 cites W2519510391 @default.
- W4281763444 cites W2528242093 @default.
- W4281763444 cites W2529114944 @default.
- W4281763444 cites W2556106115 @default.
- W4281763444 cites W2565718596 @default.
- W4281763444 cites W2566099971 @default.
- W4281763444 cites W2572398654 @default.
- W4281763444 cites W2586300905 @default.
- W4281763444 cites W2588626605 @default.
- W4281763444 cites W2589758965 @default.
- W4281763444 cites W2593691145 @default.
- W4281763444 cites W2599180887 @default.
- W4281763444 cites W2602700371 @default.
- W4281763444 cites W2604469807 @default.
- W4281763444 cites W2606051452 @default.
- W4281763444 cites W2618863496 @default.
- W4281763444 cites W2738743019 @default.
- W4281763444 cites W2743930068 @default.
- W4281763444 cites W2765902909 @default.
- W4281763444 cites W2768268612 @default.
- W4281763444 cites W2785903681 @default.
- W4281763444 cites W2808238332 @default.
- W4281763444 cites W2824830902 @default.
- W4281763444 cites W2885588864 @default.
- W4281763444 cites W2899627734 @default.
- W4281763444 cites W2901979245 @default.
- W4281763444 cites W2903233854 @default.
- W4281763444 cites W2908563052 @default.
- W4281763444 cites W2909889681 @default.
- W4281763444 cites W2913950552 @default.
- W4281763444 cites W2914029654 @default.
- W4281763444 cites W2924479779 @default.
- W4281763444 cites W2929744948 @default.
- W4281763444 cites W2965717703 @default.
- W4281763444 cites W2970701388 @default.
- W4281763444 cites W2980881483 @default.
- W4281763444 cites W2998275298 @default.
- W4281763444 cites W3012083507 @default.
- W4281763444 cites W3013242926 @default.
- W4281763444 cites W3015051483 @default.
- W4281763444 cites W3015345942 @default.
- W4281763444 cites W3028216699 @default.
- W4281763444 cites W3040963825 @default.
- W4281763444 cites W3041045393 @default.
- W4281763444 cites W3042751537 @default.
- W4281763444 cites W3045471137 @default.
- W4281763444 cites W3046853160 @default.
- W4281763444 cites W3092981856 @default.
- W4281763444 cites W3100771491 @default.
- W4281763444 cites W3102426258 @default.
- W4281763444 cites W3109063372 @default.
- W4281763444 cites W3127371223 @default.
- W4281763444 cites W3129305070 @default.
- W4281763444 cites W3133746780 @default.
- W4281763444 cites W3138431202 @default.
- W4281763444 cites W3152050242 @default.
- W4281763444 cites W3155125407 @default.
- W4281763444 cites W3164236065 @default.
- W4281763444 cites W3176139077 @default.
- W4281763444 cites W3193656600 @default.
- W4281763444 cites W3201265858 @default.
- W4281763444 cites W4206092517 @default.