FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281763856> ?p ?o ?g. }

• W4281763856 endingPage "174" @default.
• W4281763856 startingPage "161" @default.
• W4281763856 abstract "Autoimmune diseases have long been known to share a common pathogenesis involving a dysregulated immune system with a failure to recognize self from non-self-antigens. This immune dysregulation is now increasingly understood to be induced by environmental triggers in genetically predisposed individuals. Although several external environmental triggers have been defined in different autoimmune diseases, much attention is being paid to the role of the internal micro-environment occupied by the microbiome, which was once termed the forgotten organ. In this regard, the gut microbiome, serving as an intermediary between some of those external environmental effectors and the immune system, helps programming of the immune system to be tolerant to innocent external and self-antigens. However, in the presence of perturbed gut microbiota (dysbiosis), the immune system could be erroneously directed in favor of pro-inflammatory pathways to instigate different autoimmune processes. An accumulating body of evidence, including both experimental and human studies (observational and interventional), points to the role of the gut microbiome in different autoimmune diseases. Such evidence could provide a rationale for gut microbiome manipulation with therapeutic and even preventative intent in patients with established or predisposed to autoimmune diseases, respectively. Perturbations of the gut microbiome have been delineated in some immune mediated diseases, IBD in particular. However, such patterns of disturbance (microbiome signatures) and related pathogenetic roles of the gut microbiome are context dependent and cannot be generalized in the same exact way to other autoimmune disorders, and the contribution of the gut microbiome to different disease phenotypes has to be precisely defined. In this review, we revise the evidence for a role of the gut microbiome in various autoimmune diseases and possible mechanisms mediating such a role." @default.
• W4281763856 created "2022-06-13" @default.
• W4281763856 creator A5006752989 @default.
• W4281763856 creator A5015596768 @default.
• W4281763856 creator A5031311628 @default.
• W4281763856 date "2022-06-02" @default.
• W4281763856 modified "2023-10-16" @default.
• W4281763856 title "Gut microbiome and autoimmune disorders" @default.
• W4281763856 cites W1599990276 @default.
• W4281763856 cites W1663392211 @default.
• W4281763856 cites W1761300068 @default.
• W4281763856 cites W177009614 @default.
• W4281763856 cites W184362320 @default.
• W4281763856 cites W1903258410 @default.
• W4281763856 cites W1913779731 @default.
• W4281763856 cites W1926754547 @default.
• W4281763856 cites W1932943388 @default.
• W4281763856 cites W1980546883 @default.
• W4281763856 cites W1984281931 @default.
• W4281763856 cites W1989750925 @default.
• W4281763856 cites W2005151284 @default.
• W4281763856 cites W2009250605 @default.
• W4281763856 cites W2024346860 @default.
• W4281763856 cites W2029310248 @default.
• W4281763856 cites W2032605132 @default.
• W4281763856 cites W2034598453 @default.
• W4281763856 cites W2037907937 @default.
• W4281763856 cites W2038554929 @default.
• W4281763856 cites W2049448291 @default.
• W4281763856 cites W2051016124 @default.
• W4281763856 cites W2052020987 @default.
• W4281763856 cites W2055266605 @default.
• W4281763856 cites W2081864509 @default.
• W4281763856 cites W2091313460 @default.
• W4281763856 cites W2091552595 @default.
• W4281763856 cites W2097124003 @default.
• W4281763856 cites W2105952194 @default.
• W4281763856 cites W2112325559 @default.
• W4281763856 cites W2122439340 @default.
• W4281763856 cites W2125524268 @default.
• W4281763856 cites W2133169528 @default.
• W4281763856 cites W2135144327 @default.
• W4281763856 cites W2140815829 @default.
• W4281763856 cites W2143844722 @default.
• W4281763856 cites W2151417532 @default.
• W4281763856 cites W2153608030 @default.
• W4281763856 cites W2163460114 @default.
• W4281763856 cites W2167036594 @default.
• W4281763856 cites W2172910482 @default.
• W4281763856 cites W2221638611 @default.
• W4281763856 cites W2252636341 @default.
• W4281763856 cites W2260815707 @default.
• W4281763856 cites W2273051958 @default.
• W4281763856 cites W2274550287 @default.
• W4281763856 cites W2298542324 @default.
• W4281763856 cites W2301342743 @default.
• W4281763856 cites W2325771122 @default.
• W4281763856 cites W2328023807 @default.
• W4281763856 cites W2340491704 @default.
• W4281763856 cites W2340889176 @default.
• W4281763856 cites W2345604850 @default.
• W4281763856 cites W2345975446 @default.
• W4281763856 cites W2461427666 @default.
• W4281763856 cites W2461853012 @default.
• W4281763856 cites W2462641913 @default.
• W4281763856 cites W2463823637 @default.
• W4281763856 cites W2518730393 @default.
• W4281763856 cites W2519633773 @default.
• W4281763856 cites W2552260644 @default.
• W4281763856 cites W2559999430 @default.
• W4281763856 cites W2564536201 @default.
• W4281763856 cites W2565914906 @default.
• W4281763856 cites W2566286661 @default.
• W4281763856 cites W2592329788 @default.
• W4281763856 cites W2610362303 @default.
• W4281763856 cites W2618592868 @default.
• W4281763856 cites W2625740605 @default.
• W4281763856 cites W2668221420 @default.
• W4281763856 cites W2733524369 @default.
• W4281763856 cites W2735051210 @default.
• W4281763856 cites W2735259022 @default.
• W4281763856 cites W2750838281 @default.
• W4281763856 cites W2751587841 @default.
• W4281763856 cites W2755565506 @default.
• W4281763856 cites W2756391458 @default.
• W4281763856 cites W2761435270 @default.
• W4281763856 cites W2765210706 @default.
• W4281763856 cites W2766237461 @default.
• W4281763856 cites W2769170966 @default.
• W4281763856 cites W2782562442 @default.
• W4281763856 cites W2790320766 @default.
• W4281763856 cites W2791797299 @default.
• W4281763856 cites W2792609405 @default.
• W4281763856 cites W2792933846 @default.
• W4281763856 cites W2793436837 @default.
• W4281763856 cites W2799848487 @default.
• W4281763856 cites W2803028737 @default.
• W4281763856 cites W2803669783 @default.

• next