FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281766832> ?p ?o ?g. }

• W4281766832 endingPage "527" @default.
• W4281766832 startingPage "520" @default.
• W4281766832 abstract "Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including Th2 cells and ILC2s. Recent studies have revealed that STAT3 expressed in epithelial cells protects against pathogens and maintains homeostasis in the intestine. However, the roles of STAT3 in airway epithelium are poorly understood. Therefore, we sought to elucidate the roles of airway epithelial STAT3 in allergic airway inflammation.Allergic airway inflammation was induced by intratracheal administration of house dust mite (HDM) extract in doxycycline-induced AEC-specific STAT3-deficient (STAT3-cKO) mice and their genetic control (STAT3-WT) mice. Airway inflammation was evaluated by flow cytometric analysis of bronchoalveolar lavage fluid cells and histological analysis of the lung. Purified airway epithelial cells were analyzed by quantitative PCR and RNA-sequencing (RNA-seq).HDM-induced airway inflammation was exacerbated in STAT3-cKO mice compared with STAT3-WT mice. RNA-seq analyses revealed that Scd1, coding stearoyl-CoA desaturase 1, was most significantly upregulated in HDM-treated STAT3-WT mice compared to HDM-treated STAT3-cKO mice. Notably, the administration of an SCD1 inhibitor exacerbated HDM-induced airway inflammation. AECs of HDM-treated STAT3-cKO mice and those of HDM-treated SCD1 inhibitor-injected mice shared 45 differentially expressed genes (DEGs). Gene enrichment analysis of the DEGs revealed that the enriched ontology clusters included fatty acid biosynthetic process and regulation of lipid biosynthetic process, suggesting the involvement of the STAT3-SCD1-lipid metabolism axis in suppressing allergic inflammation.STAT3 is crucial for suppressing HDM-induced allergic airway inflammation, possibly inducing SCD1 expression in AECs." @default.
• W4281766832 created "2022-06-13" @default.
• W4281766832 creator A5011478547 @default.
• W4281766832 creator A5021203395 @default.
• W4281766832 creator A5025953294 @default.
• W4281766832 creator A5028396900 @default.
• W4281766832 creator A5036684201 @default.
• W4281766832 creator A5038911777 @default.
• W4281766832 creator A5054618323 @default.
• W4281766832 creator A5063727793 @default.
• W4281766832 creator A5069711734 @default.
• W4281766832 creator A5087771741 @default.
• W4281766832 date "2022-10-01" @default.
• W4281766832 modified "2023-09-28" @default.
• W4281766832 title "Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1" @default.
• W4281766832 cites W1671779243 @default.
• W4281766832 cites W1924842828 @default.
• W4281766832 cites W1957571574 @default.
• W4281766832 cites W1983930473 @default.
• W4281766832 cites W2036163316 @default.
• W4281766832 cites W2061435251 @default.
• W4281766832 cites W2092520647 @default.
• W4281766832 cites W2092790181 @default.
• W4281766832 cites W2100859614 @default.
• W4281766832 cites W2103010344 @default.
• W4281766832 cites W2103153413 @default.
• W4281766832 cites W2107066107 @default.
• W4281766832 cites W2124832395 @default.
• W4281766832 cites W2136075519 @default.
• W4281766832 cites W2145675697 @default.
• W4281766832 cites W2145946501 @default.
• W4281766832 cites W2163381313 @default.
• W4281766832 cites W2165912352 @default.
• W4281766832 cites W2169355315 @default.
• W4281766832 cites W2179438025 @default.
• W4281766832 cites W2335963744 @default.
• W4281766832 cites W2547794794 @default.
• W4281766832 cites W2589871659 @default.
• W4281766832 cites W2602928367 @default.
• W4281766832 cites W2607510234 @default.
• W4281766832 cites W2744103874 @default.
• W4281766832 cites W2749158100 @default.
• W4281766832 cites W2784209389 @default.
• W4281766832 cites W2800386729 @default.
• W4281766832 cites W2928665623 @default.
• W4281766832 cites W2946068398 @default.
• W4281766832 cites W35957379 @default.
• W4281766832 cites W4211175431 @default.
• W4281766832 cites W4313347835 @default.
• W4281766832 doi "https://doi.org/10.1016/j.alit.2022.05.002" @default.
• W4281766832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35660131" @default.
• W4281766832 hasPublicationYear "2022" @default.
• W4281766832 type Work @default.
• W4281766832 citedByCount "1" @default.
• W4281766832 countsByYear W42817668322022 @default.
• W4281766832 crossrefType "journal-article" @default.
• W4281766832 hasAuthorship W4281766832A5011478547 @default.
• W4281766832 hasAuthorship W4281766832A5021203395 @default.
• W4281766832 hasAuthorship W4281766832A5025953294 @default.
• W4281766832 hasAuthorship W4281766832A5028396900 @default.
• W4281766832 hasAuthorship W4281766832A5036684201 @default.
• W4281766832 hasAuthorship W4281766832A5038911777 @default.
• W4281766832 hasAuthorship W4281766832A5054618323 @default.
• W4281766832 hasAuthorship W4281766832A5063727793 @default.
• W4281766832 hasAuthorship W4281766832A5069711734 @default.
• W4281766832 hasAuthorship W4281766832A5087771741 @default.
• W4281766832 hasConcept C104317684 @default.
• W4281766832 hasConcept C126322002 @default.
• W4281766832 hasConcept C127561419 @default.
• W4281766832 hasConcept C203014093 @default.
• W4281766832 hasConcept C2776914184 @default.
• W4281766832 hasConcept C2777714996 @default.
• W4281766832 hasConcept C2777961210 @default.
• W4281766832 hasConcept C2778923194 @default.
• W4281766832 hasConcept C2779675166 @default.
• W4281766832 hasConcept C55493867 @default.
• W4281766832 hasConcept C62478195 @default.
• W4281766832 hasConcept C71924100 @default.
• W4281766832 hasConcept C86803240 @default.
• W4281766832 hasConcept C8891405 @default.
• W4281766832 hasConcept C95444343 @default.
• W4281766832 hasConceptScore W4281766832C104317684 @default.
• W4281766832 hasConceptScore W4281766832C126322002 @default.
• W4281766832 hasConceptScore W4281766832C127561419 @default.
• W4281766832 hasConceptScore W4281766832C203014093 @default.
• W4281766832 hasConceptScore W4281766832C2776914184 @default.
• W4281766832 hasConceptScore W4281766832C2777714996 @default.
• W4281766832 hasConceptScore W4281766832C2777961210 @default.
• W4281766832 hasConceptScore W4281766832C2778923194 @default.
• W4281766832 hasConceptScore W4281766832C2779675166 @default.
• W4281766832 hasConceptScore W4281766832C55493867 @default.
• W4281766832 hasConceptScore W4281766832C62478195 @default.
• W4281766832 hasConceptScore W4281766832C71924100 @default.
• W4281766832 hasConceptScore W4281766832C86803240 @default.
• W4281766832 hasConceptScore W4281766832C8891405 @default.
• W4281766832 hasConceptScore W4281766832C95444343 @default.
• W4281766832 hasFunder F4320309807 @default.
• W4281766832 hasFunder F4320315887 @default.

• next