Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281774563> ?p ?o ?g. }
- W4281774563 abstract "In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the world. As an important model animal, the characteristics of gut microbiota alteration in mice with NAFLD have been studied but the changes in metabolite abundance in NAFLD mice and how the gut microbiota affects these intestinal metabolites remain unclear. In this experiment, a mouse model for NAFLD was established by a high-fat diet. The use of 16S rDNA technology showed that while there were no significant changes in the alpha diversity in the cecum of NAFLD mice, the beta diversity changed significantly. The abundance of Blautia , Unidentified-Lachnospiraceae , Romboutsia , Faecalibaculum , and Ileibacterium increased significantly in NAFLD mice, while Allobaculum and Enterorhabdus decreased significantly. Amino acids, lipids, bile acids and nucleotide metabolites were among the 167 significantly different metabolites selected. The metabolic pathways of amino acids, SFAs, and bile acids were significantly enhanced, while the metabolic pathways of PUFAs, vitamins, and nucleotides were significantly inhibited. Through correlation and MIMOSA2 analysis, it is suggested that gut microbiota does not affect the changes of lipids and bile acids but can reduce thiamine, pyridoxine, and promote L-phenylalanine and tyramine production. The findings of this study will help us to better understand the relationship between gut microbiota and metabolites in NAFLD." @default.
- W4281774563 created "2022-06-13" @default.
- W4281774563 creator A5003775723 @default.
- W4281774563 creator A5004112412 @default.
- W4281774563 creator A5005882806 @default.
- W4281774563 creator A5023727584 @default.
- W4281774563 creator A5025170746 @default.
- W4281774563 creator A5032600404 @default.
- W4281774563 creator A5039205731 @default.
- W4281774563 creator A5046663841 @default.
- W4281774563 creator A5047463169 @default.
- W4281774563 creator A5049402685 @default.
- W4281774563 creator A5052297489 @default.
- W4281774563 creator A5053289077 @default.
- W4281774563 creator A5059585380 @default.
- W4281774563 creator A5061421808 @default.
- W4281774563 creator A5066353712 @default.
- W4281774563 creator A5078722034 @default.
- W4281774563 creator A5088775036 @default.
- W4281774563 creator A5088927271 @default.
- W4281774563 creator A5089440106 @default.
- W4281774563 date "2022-05-27" @default.
- W4281774563 modified "2023-10-16" @default.
- W4281774563 title "The Microbiota and It’s Correlation With Metabolites in the Gut of Mice With Nonalcoholic Fatty Liver Disease" @default.
- W4281774563 cites W1580723104 @default.
- W4281774563 cites W1803443273 @default.
- W4281774563 cites W1878890249 @default.
- W4281774563 cites W1938565647 @default.
- W4281774563 cites W1968659063 @default.
- W4281774563 cites W1977179270 @default.
- W4281774563 cites W1977368374 @default.
- W4281774563 cites W1981490181 @default.
- W4281774563 cites W1983417944 @default.
- W4281774563 cites W1984916935 @default.
- W4281774563 cites W1991757466 @default.
- W4281774563 cites W2003862189 @default.
- W4281774563 cites W2025939422 @default.
- W4281774563 cites W2048853985 @default.
- W4281774563 cites W2062237920 @default.
- W4281774563 cites W2067094344 @default.
- W4281774563 cites W2103861931 @default.
- W4281774563 cites W2104890139 @default.
- W4281774563 cites W2109746584 @default.
- W4281774563 cites W2111244421 @default.
- W4281774563 cites W2127511909 @default.
- W4281774563 cites W2138419214 @default.
- W4281774563 cites W2140264503 @default.
- W4281774563 cites W2141137078 @default.
- W4281774563 cites W2153965615 @default.
- W4281774563 cites W2154596414 @default.
- W4281774563 cites W2157431532 @default.
- W4281774563 cites W2158630697 @default.
- W4281774563 cites W2158958532 @default.
- W4281774563 cites W2164027931 @default.
- W4281774563 cites W2201555220 @default.
- W4281774563 cites W2205314138 @default.
- W4281774563 cites W2214052783 @default.
- W4281774563 cites W2262277611 @default.
- W4281774563 cites W2288689648 @default.
- W4281774563 cites W2290005847 @default.
- W4281774563 cites W2319085923 @default.
- W4281774563 cites W2399455635 @default.
- W4281774563 cites W2403968062 @default.
- W4281774563 cites W2412040979 @default.
- W4281774563 cites W2420715209 @default.
- W4281774563 cites W2522607218 @default.
- W4281774563 cites W2530466621 @default.
- W4281774563 cites W2537269837 @default.
- W4281774563 cites W2591245314 @default.
- W4281774563 cites W2604401189 @default.
- W4281774563 cites W2605349659 @default.
- W4281774563 cites W2618671443 @default.
- W4281774563 cites W2625861313 @default.
- W4281774563 cites W2724601223 @default.
- W4281774563 cites W2744389809 @default.
- W4281774563 cites W2775388128 @default.
- W4281774563 cites W2780172545 @default.
- W4281774563 cites W2790364467 @default.
- W4281774563 cites W2800793871 @default.
- W4281774563 cites W2806696121 @default.
- W4281774563 cites W2890430271 @default.
- W4281774563 cites W2894120184 @default.
- W4281774563 cites W2897091331 @default.
- W4281774563 cites W2901876957 @default.
- W4281774563 cites W2905701336 @default.
- W4281774563 cites W2920192825 @default.
- W4281774563 cites W2922188864 @default.
- W4281774563 cites W2935715550 @default.
- W4281774563 cites W2939130206 @default.
- W4281774563 cites W2940657120 @default.
- W4281774563 cites W2944184554 @default.
- W4281774563 cites W2955605041 @default.
- W4281774563 cites W2964724144 @default.
- W4281774563 cites W2966557967 @default.
- W4281774563 cites W2971459707 @default.
- W4281774563 cites W2981885402 @default.
- W4281774563 cites W2986700091 @default.
- W4281774563 cites W2993474071 @default.
- W4281774563 cites W2998274831 @default.
- W4281774563 cites W2998935115 @default.