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- W4281780198 endingPage "3490" @default.
- W4281780198 startingPage "3490" @default.
- W4281780198 abstract "A lethal condition at the arterial-alveolar juncture caused the exhaustive remodeling of pulmonary arterioles and persistent vasoconstriction, followed by a cumulative augmentation of resistance at the pulmonary vascular and, consequently, right-heart collapse. The selective dilation of the pulmonary endothelium and remodeled vasculature can be achieved by using targeted drug delivery in PAH. Although 12 therapeutics were approved by the FDA for PAH, because of traditional non-specific targeting, they suffered from inconsistent drug release. Despite available inhalation delivery platforms, drug particle deposition into the microenvironment of the pulmonary vasculature and the consequent efficacy of molecules are influenced by pathophysiological conditions, the characteristics of aerosolized mist, and formulations. Uncertainty exists in peripheral hemodynamics outside the pulmonary vasculature and extra-pulmonary side effects, which may be further exacerbated by underlying disease states. The speedy improvement of arterial pressure is possible via the inhalation route because it has direct access to pulmonary arterioles. Additionally, closed particle deposition and accumulation in diseased tissues benefit the restoration of remolded arterioles by reducing fallacious drug deposition in other organs. This review is designed to decipher the pathological changes that should be taken into account when targeting the underlying pulmonary endothelial vasculature, especially with regard to inhaled particle deposition in the alveolar vasculature and characteristic formulations." @default.
- W4281780198 created "2022-06-13" @default.
- W4281780198 creator A5008387075 @default.
- W4281780198 creator A5015791582 @default.
- W4281780198 creator A5023622012 @default.
- W4281780198 creator A5043082541 @default.
- W4281780198 creator A5063029157 @default.
- W4281780198 date "2022-05-29" @default.
- W4281780198 modified "2023-10-16" @default.
- W4281780198 title "An Update on Advancements and Challenges in Inhalational Drug Delivery for Pulmonary Arterial Hypertension" @default.
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