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- W4281781168 abstract "Abstract Background Some circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner. Internal ribosomal entry site (IRES) and N 6 -methyladenosine (m 6 A) were reported to drive translation of circRNAs. Experimental methods confirming the presence of IRES and m 6 A site are time consuming and labor intensive. Lacking computational tools to predict ORFs, IRESs and m 6 A sites for circRNAs makes it harder. Results In this report, we present circPrimer 2.0, a Java based software for annotating circRNAs and predicting ORFs, IRESs, and m6A sites of circRNAs. circPrimer 2.0 has a graphical and a command-line interface that enables the tool to be embed into an analysis pipeline. Conclusions circprimer 2.0 is an easy-to-use software for annotating circRNAs and predicting translation potential of circRNAs, and freely available at www.bio-inf.cn ." @default.
- W4281781168 created "2022-06-13" @default.
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- W4281781168 date "2022-06-06" @default.
- W4281781168 modified "2023-10-09" @default.
- W4281781168 title "CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs" @default.
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- W4281781168 doi "https://doi.org/10.1186/s12859-022-04705-y" @default.
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