FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281782644> ?p ?o ?g. }

• W4281782644 endingPage "305" @default.
• W4281782644 startingPage "297" @default.
• W4281782644 abstract "Stratification of patients with triple-negative breast cancer (TNBC) for anti-PD-L1 therapy is based on PD-L1 expression in tumor biopsies. This study sought to evaluate the risk of PD-L1 misclassification.We conducted a high-resolution analysis on ten surgical specimens of TNBC. First, we determined PD-L1 expression pattern distribution via manual segmentation and measurement of 6666 microscopic clusters of positive PD-L1 immunohistochemical staining. Then, based on these results, we generated a computer model to calculate the effect of the positive PD-L1 fraction, aggregate size, and distribution of PD-L1 positive cells on the diagnostic accuracy.Our computer-based model showed that larger aggregates of PD-L1 positive cells and smaller biopsy size were associated with higher fraction of false results (P < 0.001, P < 0.001, respectively). Additionally, our model showed a significant increase in error rate when the fraction of PD-L1 expression was close to the cut-off (error rate of 12.1%, 0.84%, and 0.65% for PD-L1 positivity of 0.5-1.5%, ≤ 0.5% ,and ≥ 1.5%, respectively, P < 0.0001). Interestingly, false positive results were significantly higher than false negative results (0.51-22.62%, with an average of 6.31% versus 0.11-11.36% with an average of 1.58% for false positive and false negative results, respectively, P < 0.05). Furthermore, heterogeneous tumors with different aggregate sizes in the same tumor, were associated with increased rate of false results in comparison to homogenous tumors (P < 0.001).Our model can be used to estimate the risk of PD-L1 misclassification in biopsies, with potential implications for treatment decisions." @default.
• W4281782644 created "2022-06-13" @default.
• W4281782644 creator A5005293725 @default.
• W4281782644 creator A5024494755 @default.
• W4281782644 creator A5036318503 @default.
• W4281782644 creator A5042641044 @default.
• W4281782644 creator A5046861683 @default.
• W4281782644 creator A5071742598 @default.
• W4281782644 date "2022-05-27" @default.
• W4281782644 modified "2023-10-10" @default.
• W4281782644 title "The risk of PD-L1 expression misclassification in triple-negative breast cancer" @default.
• W4281782644 cites W2022465587 @default.
• W4281782644 cites W2118396147 @default.
• W4281782644 cites W2210073947 @default.
• W4281782644 cites W2465688720 @default.
• W4281782644 cites W2522296004 @default.
• W4281782644 cites W2527905628 @default.
• W4281782644 cites W2560367415 @default.
• W4281782644 cites W2561642944 @default.
• W4281782644 cites W2569413005 @default.
• W4281782644 cites W2587364318 @default.
• W4281782644 cites W2800631768 @default.
• W4281782644 cites W2897422388 @default.
• W4281782644 cites W2940759533 @default.
• W4281782644 cites W2972289446 @default.
• W4281782644 cites W2979531778 @default.
• W4281782644 cites W3003627105 @default.
• W4281782644 cites W3006930853 @default.
• W4281782644 cites W3022978907 @default.
• W4281782644 cites W3033869790 @default.
• W4281782644 cites W3042699069 @default.
• W4281782644 cites W3173705400 @default.
• W4281782644 cites W3186122809 @default.
• W4281782644 cites W4205617437 @default.
• W4281782644 doi "https://doi.org/10.1007/s10549-022-06630-3" @default.
• W4281782644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35622241" @default.
• W4281782644 hasPublicationYear "2022" @default.
• W4281782644 type Work @default.
• W4281782644 citedByCount "1" @default.
• W4281782644 crossrefType "journal-article" @default.
• W4281782644 hasAuthorship W4281782644A5005293725 @default.
• W4281782644 hasAuthorship W4281782644A5024494755 @default.
• W4281782644 hasAuthorship W4281782644A5036318503 @default.
• W4281782644 hasAuthorship W4281782644A5042641044 @default.
• W4281782644 hasAuthorship W4281782644A5046861683 @default.
• W4281782644 hasAuthorship W4281782644A5071742598 @default.
• W4281782644 hasBestOaLocation W42817826441 @default.
• W4281782644 hasConcept C104317684 @default.
• W4281782644 hasConcept C105795698 @default.
• W4281782644 hasConcept C121608353 @default.
• W4281782644 hasConcept C126322002 @default.
• W4281782644 hasConcept C142724271 @default.
• W4281782644 hasConcept C143998085 @default.
• W4281782644 hasConcept C193244246 @default.
• W4281782644 hasConcept C204232928 @default.
• W4281782644 hasConcept C2775934546 @default.
• W4281782644 hasConcept C2780110267 @default.
• W4281782644 hasConcept C33923547 @default.
• W4281782644 hasConcept C530470458 @default.
• W4281782644 hasConcept C55493867 @default.
• W4281782644 hasConcept C71924100 @default.
• W4281782644 hasConcept C86803240 @default.
• W4281782644 hasConcept C95922358 @default.
• W4281782644 hasConceptScore W4281782644C104317684 @default.
• W4281782644 hasConceptScore W4281782644C105795698 @default.
• W4281782644 hasConceptScore W4281782644C121608353 @default.
• W4281782644 hasConceptScore W4281782644C126322002 @default.
• W4281782644 hasConceptScore W4281782644C142724271 @default.
• W4281782644 hasConceptScore W4281782644C143998085 @default.
• W4281782644 hasConceptScore W4281782644C193244246 @default.
• W4281782644 hasConceptScore W4281782644C204232928 @default.
• W4281782644 hasConceptScore W4281782644C2775934546 @default.
• W4281782644 hasConceptScore W4281782644C2780110267 @default.
• W4281782644 hasConceptScore W4281782644C33923547 @default.
• W4281782644 hasConceptScore W4281782644C530470458 @default.
• W4281782644 hasConceptScore W4281782644C55493867 @default.
• W4281782644 hasConceptScore W4281782644C71924100 @default.
• W4281782644 hasConceptScore W4281782644C86803240 @default.
• W4281782644 hasConceptScore W4281782644C95922358 @default.
• W4281782644 hasIssue "2" @default.
• W4281782644 hasLocation W42817826441 @default.
• W4281782644 hasLocation W42817826442 @default.
• W4281782644 hasLocation W42817826443 @default.
• W4281782644 hasOpenAccess W4281782644 @default.
• W4281782644 hasPrimaryLocation W42817826441 @default.
• W4281782644 hasRelatedWork W1999292713 @default.
• W4281782644 hasRelatedWork W2139975046 @default.
• W4281782644 hasRelatedWork W2224319365 @default.
• W4281782644 hasRelatedWork W2317787856 @default.
• W4281782644 hasRelatedWork W2331329572 @default.
• W4281782644 hasRelatedWork W2376078656 @default.
• W4281782644 hasRelatedWork W2554176272 @default.
• W4281782644 hasRelatedWork W3044626609 @default.
• W4281782644 hasRelatedWork W3186761709 @default.
• W4281782644 hasRelatedWork W4224327237 @default.
• W4281782644 hasVolume "194" @default.
• W4281782644 isParatext "false" @default.
• W4281782644 isRetracted "false" @default.

• next