FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281783223> ?p ?o ?g. }

• W4281783223 abstract "Eosinophilic esophagitis (EoE) is an allergen-mediated disease and elimination diets have proven to be effective to obtain clinical and histological remission. However, the effect of elimination diets on specific EoE transcripts and their clinical correlates is relatively unknown. The main aim of the study was to evaluate the effect of dietary treatment (four-food elimination diet [FFED]) with or without addition of amino acid-based formula (AAF) on a variety of pro-/anti-inflammatory, epithelial/barrier function and remodeling/fibrosis-related markers of disease activity and clinical correlates (eosinophils, symptoms, and endoscopic signs) in adult EoE patients.We conducted an analysis of biopsy samples and data collected during a randomized controlled trial with an elimination diet in adult patients with active EoE (≥15 eosinophils [eos] per high-power field [hpf]). Demographics, symptoms (SDI-score), endoscopic signs (EREFS) and peak eosinophil counts/hpf were recorded at baseline and after 6 weeks of treatment. Transcripts of 10 indicated genes were measured (qPCR) and compared to clinical correlates at baseline and after treatment.Forty patients (pooled FFED + FFED + AAF) (60% male, age 34.5 (interquartile range [IQR] 29-42.8 years) completed the diet. Peak eosinophil counts/hpf, symptoms and endoscopic signs were significantly decreased after 6 weeks dietary treatment. DSG-1 levels were significantly upregulated from baseline to week 6, whereas IL-13, CAPN-14, IL-5, IL-10, CCL-26, POSTN, TSLP, CPA-3, and TGF-β were significantly downregulated after 6 weeks of diet (all; <0.01). Prior to treatment, upregulation of CAPN-14 and lower levels of DSG-1 were associated with clinical fibrotic phenotypes, whereas upregulation of IL-10 was linked to food impaction phenotypes.These findings strongly suggest that elimination diets, besides a clinical and histological response, are associated with a broad transcriptional response at the level of the esophageal epithelium." @default.
• W4281783223 created "2022-06-13" @default.
• W4281783223 creator A5011920358 @default.
• W4281783223 creator A5033250803 @default.
• W4281783223 creator A5035939684 @default.
• W4281783223 creator A5055596764 @default.
• W4281783223 creator A5069482286 @default.
• W4281783223 creator A5072654925 @default.
• W4281783223 date "2022-06-05" @default.
• W4281783223 modified "2023-09-26" @default.
• W4281783223 title "Gene expression and clinical outcomes after dietary treatment for eosinophilic esophagitis: a prospective study" @default.
• W4281783223 cites W1582324223 @default.
• W4281783223 cites W1860045332 @default.
• W4281783223 cites W1965860865 @default.
• W4281783223 cites W1970365072 @default.
• W4281783223 cites W1972578247 @default.
• W4281783223 cites W1981091383 @default.
• W4281783223 cites W1993253390 @default.
• W4281783223 cites W1993906124 @default.
• W4281783223 cites W1995481725 @default.
• W4281783223 cites W2013221728 @default.
• W4281783223 cites W2019152596 @default.
• W4281783223 cites W2034453465 @default.
• W4281783223 cites W2057085451 @default.
• W4281783223 cites W2064326663 @default.
• W4281783223 cites W2077290680 @default.
• W4281783223 cites W2086384139 @default.
• W4281783223 cites W2087253281 @default.
• W4281783223 cites W2087770516 @default.
• W4281783223 cites W2088448145 @default.
• W4281783223 cites W2097643518 @default.
• W4281783223 cites W2098392838 @default.
• W4281783223 cites W2106081478 @default.
• W4281783223 cites W2108703504 @default.
• W4281783223 cites W2136248567 @default.
• W4281783223 cites W2137277707 @default.
• W4281783223 cites W2164161262 @default.
• W4281783223 cites W2168008725 @default.
• W4281783223 cites W2313530450 @default.
• W4281783223 cites W2342679639 @default.
• W4281783223 cites W2416344209 @default.
• W4281783223 cites W2421238964 @default.
• W4281783223 cites W2466463186 @default.
• W4281783223 cites W2580861314 @default.
• W4281783223 cites W2581811861 @default.
• W4281783223 cites W2607384000 @default.
• W4281783223 cites W2741734981 @default.
• W4281783223 cites W2752116564 @default.
• W4281783223 cites W2766716914 @default.
• W4281783223 cites W2783144429 @default.
• W4281783223 cites W2794769142 @default.
• W4281783223 cites W2799383149 @default.
• W4281783223 cites W2803354549 @default.
• W4281783223 cites W2883311417 @default.
• W4281783223 cites W2899160869 @default.
• W4281783223 cites W3089470485 @default.
• W4281783223 cites W3093931446 @default.
• W4281783223 cites W3214230689 @default.
• W4281783223 cites W4281783223 @default.
• W4281783223 cites W611749901 @default.
• W4281783223 cites W942742825 @default.
• W4281783223 doi "https://doi.org/10.1111/nmo.14367" @default.
• W4281783223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35661487" @default.
• W4281783223 hasPublicationYear "2022" @default.
• W4281783223 type Work @default.
• W4281783223 citedByCount "1" @default.
• W4281783223 countsByYear W42817832232022 @default.
• W4281783223 crossrefType "journal-article" @default.
• W4281783223 hasAuthorship W4281783223A5011920358 @default.
• W4281783223 hasAuthorship W4281783223A5033250803 @default.
• W4281783223 hasAuthorship W4281783223A5035939684 @default.
• W4281783223 hasAuthorship W4281783223A5055596764 @default.
• W4281783223 hasAuthorship W4281783223A5069482286 @default.
• W4281783223 hasAuthorship W4281783223A5072654925 @default.
• W4281783223 hasBestOaLocation W42817832232 @default.
• W4281783223 hasConcept C119060515 @default.
• W4281783223 hasConcept C126322002 @default.
• W4281783223 hasConcept C203014093 @default.
• W4281783223 hasConcept C204232928 @default.
• W4281783223 hasConcept C207480886 @default.
• W4281783223 hasConcept C2776027960 @default.
• W4281783223 hasConcept C2776042228 @default.
• W4281783223 hasConcept C2777037409 @default.
• W4281783223 hasConcept C2779134260 @default.
• W4281783223 hasConcept C2779929431 @default.
• W4281783223 hasConcept C2780661616 @default.
• W4281783223 hasConcept C2781065132 @default.
• W4281783223 hasConcept C71924100 @default.
• W4281783223 hasConcept C90924648 @default.
• W4281783223 hasConceptScore W4281783223C119060515 @default.
• W4281783223 hasConceptScore W4281783223C126322002 @default.
• W4281783223 hasConceptScore W4281783223C203014093 @default.
• W4281783223 hasConceptScore W4281783223C204232928 @default.
• W4281783223 hasConceptScore W4281783223C207480886 @default.
• W4281783223 hasConceptScore W4281783223C2776027960 @default.
• W4281783223 hasConceptScore W4281783223C2776042228 @default.
• W4281783223 hasConceptScore W4281783223C2777037409 @default.
• W4281783223 hasConceptScore W4281783223C2779134260 @default.
• W4281783223 hasConceptScore W4281783223C2779929431 @default.
• W4281783223 hasConceptScore W4281783223C2780661616 @default.

• next