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• W4281785730 abstract "Abstract GGGGCC (G 4 C 2 ) hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. However, the underlying toxic species is debated, and it is not clear whether antisense CCCCGG (C 4 G 2 ) repeat expanded RNAs contribute to disease pathogenesis. Our study shows that C9orf72 (C 4 G 2 ) antisense repeat expanded RNAs trigger the activation of the PKR/eIF2α-dependent integrated stress response independent of dipeptide repeat proteins that are produced through repeat-associated non-AUG initiated translation, leading to global translation inhibition and stress granule formation. Increased phosphorylation of PKR/eIF2α is also observed in the frontal cortex of C9orf72 FTD/ALS patients. Finally, only antisense (C 4 G 2 ), but not sense (G 4 C 2 ), repeat expanded RNAs can activate the PKR/eIF2α pathway. These results provide a mechanism by which antisense repeat expanded RNAs elicit neuronal toxicity in FTD/ALS caused by C9orf72 repeat expansions." @default.
• W4281785730 created "2022-06-13" @default.
• W4281785730 creator A5006098963 @default.
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• W4281785730 date "2022-06-06" @default.
• W4281785730 modified "2023-10-04" @default.
• W4281785730 title "Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS" @default.
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• W4281785730 cites W1965975446 @default.
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• W4281785730 cites W2013488820 @default.
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• W4281785730 cites W2063996210 @default.
• W4281785730 cites W2065219073 @default.
• W4281785730 cites W2071471772 @default.
• W4281785730 cites W2079838847 @default.
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• W4281785730 cites W2139264742 @default.
• W4281785730 cites W2143035838 @default.
• W4281785730 cites W2150523249 @default.
• W4281785730 cites W2154945114 @default.
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• W4281785730 cites W2166142331 @default.
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• W4281785730 cites W222561556 @default.
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• W4281785730 cites W2304886140 @default.
• W4281785730 cites W2308742329 @default.
• W4281785730 cites W2309375248 @default.
• W4281785730 cites W2328157766 @default.
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• W4281785730 cites W2898382435 @default.
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• W4281785730 doi "https://doi.org/10.1101/2022.06.06.495030" @default.
• W4281785730 hasPublicationYear "2022" @default.
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