Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281785950> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4281785950 abstract "One new compound isoembinin 1 along with ten known compounds 2-11 were isolated from the terrestrial parts of Iris lactea Pall. All of the compound structures were determined through extensive 1D and 2D NMR experiments along with HR-ESIMS analysis and comparison with literature data. Because many flavonoids exert antiplatelet and antioxidant activity we tested the effects of the isolated flavone C-glycosides 1-9 on platelet activation and reactive oxygen species (ROS) production. Platelet reactivity was assessed by activation of αIIbβ3 integrins activation and ROS production by DCF-DA fluorescence. For the analysis of whether protein kinase A or G are involved in the platelet inhibition, the activity of these kinases was analyzed by phosphorylation of their common substrate in platelets. In all experiments apigenin, which inhibit platelet activation was used as a positive control. All isolated flavone C-glycosides inhibited platelet αIIbβ3 integrins activation with IC50 in the µM range, however this inhibitory effect was found to not be mediated through the prevention of ROS formation or by the activation of cyclic nucleotide pathways. Structure-activity comparison between apigenin and compounds 1-9 shows that the presence of C-glycoside and O-glycoside residues on the aglycone apigenin diminish the degree of platelet inhibition." @default.
- W4281785950 created "2022-06-13" @default.
- W4281785950 creator A5006373776 @default.
- W4281785950 creator A5025312655 @default.
- W4281785950 creator A5030419110 @default.
- W4281785950 creator A5037504676 @default.
- W4281785950 creator A5048501804 @default.
- W4281785950 creator A5070163293 @default.
- W4281785950 creator A5087940362 @default.
- W4281785950 date "2022-06-10" @default.
- W4281785950 modified "2023-10-07" @default.
- W4281785950 title "Isolation and Characterization of a New Flavone C-glycoside Isoembinin from Iris lacteal along with its Effects on Platelet Activation" @default.
- W4281785950 doi "https://doi.org/10.1055/a-1873-6785" @default.
- W4281785950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35688458" @default.
- W4281785950 hasPublicationYear "2022" @default.
- W4281785950 type Work @default.
- W4281785950 citedByCount "0" @default.
- W4281785950 crossrefType "journal-article" @default.
- W4281785950 hasAuthorship W4281785950A5006373776 @default.
- W4281785950 hasAuthorship W4281785950A5025312655 @default.
- W4281785950 hasAuthorship W4281785950A5030419110 @default.
- W4281785950 hasAuthorship W4281785950A5037504676 @default.
- W4281785950 hasAuthorship W4281785950A5048501804 @default.
- W4281785950 hasAuthorship W4281785950A5070163293 @default.
- W4281785950 hasAuthorship W4281785950A5087940362 @default.
- W4281785950 hasConcept C170493617 @default.
- W4281785950 hasConcept C184235292 @default.
- W4281785950 hasConcept C185592680 @default.
- W4281785950 hasConcept C194671627 @default.
- W4281785950 hasConcept C195687474 @default.
- W4281785950 hasConcept C203014093 @default.
- W4281785950 hasConcept C2778004101 @default.
- W4281785950 hasConcept C2778609962 @default.
- W4281785950 hasConcept C2779054382 @default.
- W4281785950 hasConcept C3018697912 @default.
- W4281785950 hasConcept C48349386 @default.
- W4281785950 hasConcept C55493867 @default.
- W4281785950 hasConcept C71240020 @default.
- W4281785950 hasConcept C86803240 @default.
- W4281785950 hasConcept C89560881 @default.
- W4281785950 hasConcept C98274493 @default.
- W4281785950 hasConceptScore W4281785950C170493617 @default.
- W4281785950 hasConceptScore W4281785950C184235292 @default.
- W4281785950 hasConceptScore W4281785950C185592680 @default.
- W4281785950 hasConceptScore W4281785950C194671627 @default.
- W4281785950 hasConceptScore W4281785950C195687474 @default.
- W4281785950 hasConceptScore W4281785950C203014093 @default.
- W4281785950 hasConceptScore W4281785950C2778004101 @default.
- W4281785950 hasConceptScore W4281785950C2778609962 @default.
- W4281785950 hasConceptScore W4281785950C2779054382 @default.
- W4281785950 hasConceptScore W4281785950C3018697912 @default.
- W4281785950 hasConceptScore W4281785950C48349386 @default.
- W4281785950 hasConceptScore W4281785950C55493867 @default.
- W4281785950 hasConceptScore W4281785950C71240020 @default.
- W4281785950 hasConceptScore W4281785950C86803240 @default.
- W4281785950 hasConceptScore W4281785950C89560881 @default.
- W4281785950 hasConceptScore W4281785950C98274493 @default.
- W4281785950 hasLocation W42817859501 @default.
- W4281785950 hasLocation W42817859502 @default.
- W4281785950 hasOpenAccess W4281785950 @default.
- W4281785950 hasPrimaryLocation W42817859501 @default.
- W4281785950 hasRelatedWork W2058349334 @default.
- W4281785950 hasRelatedWork W2360424051 @default.
- W4281785950 hasRelatedWork W2411921922 @default.
- W4281785950 hasRelatedWork W2557966141 @default.
- W4281785950 hasRelatedWork W2620980935 @default.
- W4281785950 hasRelatedWork W2623859343 @default.
- W4281785950 hasRelatedWork W3212725746 @default.
- W4281785950 hasRelatedWork W4363673846 @default.
- W4281785950 hasRelatedWork W56507834 @default.
- W4281785950 hasRelatedWork W606270823 @default.
- W4281785950 isParatext "false" @default.
- W4281785950 isRetracted "false" @default.
- W4281785950 workType "article" @default.