Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281788753> ?p ?o ?g. }
- W4281788753 endingPage "105363" @default.
- W4281788753 startingPage "105363" @default.
- W4281788753 abstract "The kynurenine pathway receives increasing attention due to its involvement in central nervous system pathologies, i.a. neurodegenerative and psychiatric disorders, but also due to the contribution to the pathomechanism of neoplasms, including brain tumors. The present review focuses on kynurenine pathway activity in gliomas, brain tumors of glial origin. The upregulation of kynurenine pathway enzyme, indoleamine 2,3-dioxygenase (IDO), resulting in a decreased level of tryptophan and augmented kynurenine synthesis (increased (KYN/Trp ratio) are the most recognised hallmark of malignant transformation, characterised with immunomodulatory adaptations, providing an escape from defence mechanisms of the host, growth-beneficial milieu and resistance to some therapeutics. The review addresses, however, the oxidative/nitrosative stress-associated mechanisms of tryptophan catabolism, mainly the kynurenine pathway activity, linking them with glioma pathobiology." @default.
- W4281788753 created "2022-06-13" @default.
- W4281788753 creator A5048559996 @default.
- W4281788753 date "2022-09-01" @default.
- W4281788753 modified "2023-09-27" @default.
- W4281788753 title "The tryptophan metabolism, kynurenine pathway and oxidative stress – implications for glioma pathobiology" @default.
- W4281788753 cites W1465620532 @default.
- W4281788753 cites W1505887853 @default.
- W4281788753 cites W1746762518 @default.
- W4281788753 cites W1960984962 @default.
- W4281788753 cites W1965983473 @default.
- W4281788753 cites W1966687939 @default.
- W4281788753 cites W1971547362 @default.
- W4281788753 cites W1973172818 @default.
- W4281788753 cites W1977446656 @default.
- W4281788753 cites W1978335131 @default.
- W4281788753 cites W1983447576 @default.
- W4281788753 cites W1984482190 @default.
- W4281788753 cites W1987514860 @default.
- W4281788753 cites W1991739832 @default.
- W4281788753 cites W2000183088 @default.
- W4281788753 cites W2003008219 @default.
- W4281788753 cites W2003237166 @default.
- W4281788753 cites W2007062575 @default.
- W4281788753 cites W2015649397 @default.
- W4281788753 cites W2018349068 @default.
- W4281788753 cites W2018761239 @default.
- W4281788753 cites W2020882728 @default.
- W4281788753 cites W2024913744 @default.
- W4281788753 cites W2028759836 @default.
- W4281788753 cites W2032750345 @default.
- W4281788753 cites W2033401394 @default.
- W4281788753 cites W2034000134 @default.
- W4281788753 cites W2034445899 @default.
- W4281788753 cites W2053806684 @default.
- W4281788753 cites W2055293030 @default.
- W4281788753 cites W2057539580 @default.
- W4281788753 cites W2060545665 @default.
- W4281788753 cites W2061383340 @default.
- W4281788753 cites W2064370520 @default.
- W4281788753 cites W2064683825 @default.
- W4281788753 cites W2068057586 @default.
- W4281788753 cites W2072165349 @default.
- W4281788753 cites W2077344726 @default.
- W4281788753 cites W2079427446 @default.
- W4281788753 cites W2080097363 @default.
- W4281788753 cites W2080568925 @default.
- W4281788753 cites W2085104178 @default.
- W4281788753 cites W2087714907 @default.
- W4281788753 cites W2092564510 @default.
- W4281788753 cites W2094018125 @default.
- W4281788753 cites W2111610011 @default.
- W4281788753 cites W2114391266 @default.
- W4281788753 cites W2125405007 @default.
- W4281788753 cites W2141586113 @default.
- W4281788753 cites W2144752097 @default.
- W4281788753 cites W2149398709 @default.
- W4281788753 cites W2151104072 @default.
- W4281788753 cites W2154961515 @default.
- W4281788753 cites W2164556953 @default.
- W4281788753 cites W2172206492 @default.
- W4281788753 cites W2176695138 @default.
- W4281788753 cites W2190313991 @default.
- W4281788753 cites W2192218028 @default.
- W4281788753 cites W2209613548 @default.
- W4281788753 cites W2265707827 @default.
- W4281788753 cites W2299985741 @default.
- W4281788753 cites W2306638524 @default.
- W4281788753 cites W2312018102 @default.
- W4281788753 cites W2324282973 @default.
- W4281788753 cites W2441834749 @default.
- W4281788753 cites W2471827535 @default.
- W4281788753 cites W2597174991 @default.
- W4281788753 cites W2624155732 @default.
- W4281788753 cites W2739812295 @default.
- W4281788753 cites W2739923514 @default.
- W4281788753 cites W2741302852 @default.
- W4281788753 cites W2791080175 @default.
- W4281788753 cites W2801545060 @default.
- W4281788753 cites W2802976036 @default.
- W4281788753 cites W2803170025 @default.
- W4281788753 cites W2905068048 @default.
- W4281788753 cites W2910522104 @default.
- W4281788753 cites W2912181843 @default.
- W4281788753 cites W2948841522 @default.
- W4281788753 cites W2952661933 @default.
- W4281788753 cites W2954416791 @default.
- W4281788753 cites W2979673635 @default.
- W4281788753 cites W2980333317 @default.
- W4281788753 cites W2980354659 @default.
- W4281788753 cites W2990555999 @default.
- W4281788753 cites W3005433625 @default.
- W4281788753 cites W3005765925 @default.
- W4281788753 cites W3006976689 @default.
- W4281788753 cites W3007849461 @default.
- W4281788753 cites W3008243650 @default.
- W4281788753 cites W3009867290 @default.
- W4281788753 cites W3034726568 @default.