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- W4281791708 abstract "The last major advance in HIV therapeutics came in 2007–08 with the approval of raltegravir, the first integrase strand transfer inhibitor (INSTI). 1 Max B Update on HIV integrase inhibitors for the treatment of HIV-1 infection. Future Virol. 2019; 14: 693-709 Crossref Scopus (7) Google Scholar Second generation INSTIs, dolutegravir and bictegravir, with longer half-lives and with a higher barrier to resistance in single tablet regimens have cemented this class of antiretrovirals as the preferred anchor drugs in first-line HIV therapy worldwide. 2 Panel on Antiretroviral Guidelines for Adults and AdolescentsGuidelines for the use of antiretroviral agents in adults and adolescents with HIV. Department of Health and Human Services, 2021https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/guidelines-adult-adolescent-arv.pdfDate accessed: April 14, 2022 Google Scholar , 3 WHOConsolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. https://www.who.int/publications/i/item/9789240031593]Date: 2021 Date accessed: April 6, 2022 Google Scholar Associations of modern initial antiretroviral drug regimens with all-cause mortality in adults with HIV in Europe and North America: a cohort studyThis large study of patients starting ART since the introduction of INSTIs found little evidence that mortality rates differed between most first-line ART regimens; however, raltegravir-based regimens were associated with higher mortality. Although unmeasured confounding cannot be excluded as an explanation for our findings, virological benefits of first-line INSTIs-based ART might not translate to differences in mortality. Full-Text PDF Open Access" @default.
- W4281791708 created "2022-06-13" @default.
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- W4281791708 date "2022-06-01" @default.
- W4281791708 modified "2023-10-17" @default.
- W4281791708 title "Can integrase inhibitors reduce mortality?" @default.
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- W4281791708 doi "https://doi.org/10.1016/s2352-3018(22)00103-5" @default.
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