Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281794920> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4281794920 endingPage "123595" @default.
- W4281794920 startingPage "123595" @default.
- W4281794920 abstract "Sorbitol is known as a biomarker for the evaluation of the progress of diabetic complications. We have developed a sorbitol biosensor using an optical fiber for rapid diagnosis and pathological evaluation of diabetic complications. In this paper, we measured blood sorbitol in diabetic rats using an improved biosensor, and discussed the effectiveness of the developed biosensor and the significance of sorbitol measurement. In order to investigate the effectiveness of the developed biosensor, the blood sorbitol level of type II diabetic rats prepared by streptozotocin administration was measured with the developed sensor. The values of sorbitol were highly correlated with the values measured by the F-kit of food analysis and that we confirmed the sorbitol concentration could be quantified using the developed biosensor. Furthermore, the aldose reductase inhibitor eparlrestat, which is a therapeutic drug that suppresses the accumulation of sorbitol, was administered to diabetic rats, and the blood sorbitol level was measured with the developed biosensor. As a result, the blood glucose level was high in both the treated group and the non-treated group, but the blood sorbitol level in the treated group decreased. The results suggest that the measurement of the sorbitol level with the developed biosensor in addition to the blood glucose level enables evaluation of complications like diabetic neuropathy. In the future, we expected that the developed sorbitol biosensor will be miniaturized, the pretreatment method for blood samples will be simplified, and it will be applied to the development of therapeutic agents for diabetic complications and personalized medicine." @default.
- W4281794920 created "2022-06-13" @default.
- W4281794920 creator A5007741876 @default.
- W4281794920 creator A5010212579 @default.
- W4281794920 creator A5018762692 @default.
- W4281794920 creator A5085932814 @default.
- W4281794920 date "2022-10-01" @default.
- W4281794920 modified "2023-10-18" @default.
- W4281794920 title "Blood sorbitol measurement in diabetic rats treated with an aldose reductase inhibitor using an improved fiber-optic sorbitol biosensor" @default.
- W4281794920 cites W1847469695 @default.
- W4281794920 cites W1968561916 @default.
- W4281794920 cites W1975468900 @default.
- W4281794920 cites W1981099064 @default.
- W4281794920 cites W1982452729 @default.
- W4281794920 cites W2001109862 @default.
- W4281794920 cites W2008388036 @default.
- W4281794920 cites W2020357690 @default.
- W4281794920 cites W2033678688 @default.
- W4281794920 cites W2035268635 @default.
- W4281794920 cites W2035596019 @default.
- W4281794920 cites W2044437167 @default.
- W4281794920 cites W2045909288 @default.
- W4281794920 cites W2050014245 @default.
- W4281794920 cites W2053218825 @default.
- W4281794920 cites W2082485244 @default.
- W4281794920 cites W2091352954 @default.
- W4281794920 cites W2105731956 @default.
- W4281794920 cites W2110704418 @default.
- W4281794920 cites W2113234058 @default.
- W4281794920 cites W2126946832 @default.
- W4281794920 cites W2145588197 @default.
- W4281794920 cites W2152218732 @default.
- W4281794920 cites W2401831534 @default.
- W4281794920 cites W2800038406 @default.
- W4281794920 cites W2809336184 @default.
- W4281794920 cites W2885820762 @default.
- W4281794920 doi "https://doi.org/10.1016/j.talanta.2022.123595" @default.
- W4281794920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35667186" @default.
- W4281794920 hasPublicationYear "2022" @default.
- W4281794920 type Work @default.
- W4281794920 citedByCount "3" @default.
- W4281794920 countsByYear W42817949202022 @default.
- W4281794920 countsByYear W42817949202023 @default.
- W4281794920 crossrefType "journal-article" @default.
- W4281794920 hasAuthorship W4281794920A5007741876 @default.
- W4281794920 hasAuthorship W4281794920A5010212579 @default.
- W4281794920 hasAuthorship W4281794920A5018762692 @default.
- W4281794920 hasAuthorship W4281794920A5085932814 @default.
- W4281794920 hasConcept C126322002 @default.
- W4281794920 hasConcept C134018914 @default.
- W4281794920 hasConcept C160756335 @default.
- W4281794920 hasConcept C181199279 @default.
- W4281794920 hasConcept C185592680 @default.
- W4281794920 hasConcept C2776439734 @default.
- W4281794920 hasConcept C2776779347 @default.
- W4281794920 hasConcept C2777374081 @default.
- W4281794920 hasConcept C43617362 @default.
- W4281794920 hasConcept C55493867 @default.
- W4281794920 hasConcept C555293320 @default.
- W4281794920 hasConcept C71924100 @default.
- W4281794920 hasConceptScore W4281794920C126322002 @default.
- W4281794920 hasConceptScore W4281794920C134018914 @default.
- W4281794920 hasConceptScore W4281794920C160756335 @default.
- W4281794920 hasConceptScore W4281794920C181199279 @default.
- W4281794920 hasConceptScore W4281794920C185592680 @default.
- W4281794920 hasConceptScore W4281794920C2776439734 @default.
- W4281794920 hasConceptScore W4281794920C2776779347 @default.
- W4281794920 hasConceptScore W4281794920C2777374081 @default.
- W4281794920 hasConceptScore W4281794920C43617362 @default.
- W4281794920 hasConceptScore W4281794920C55493867 @default.
- W4281794920 hasConceptScore W4281794920C555293320 @default.
- W4281794920 hasConceptScore W4281794920C71924100 @default.
- W4281794920 hasLocation W42817949201 @default.
- W4281794920 hasLocation W42817949202 @default.
- W4281794920 hasOpenAccess W4281794920 @default.
- W4281794920 hasPrimaryLocation W42817949201 @default.
- W4281794920 hasRelatedWork W2009019257 @default.
- W4281794920 hasRelatedWork W2018093451 @default.
- W4281794920 hasRelatedWork W2060342381 @default.
- W4281794920 hasRelatedWork W2084715532 @default.
- W4281794920 hasRelatedWork W2085126616 @default.
- W4281794920 hasRelatedWork W2326852908 @default.
- W4281794920 hasRelatedWork W2396914230 @default.
- W4281794920 hasRelatedWork W2431483632 @default.
- W4281794920 hasRelatedWork W4281794920 @default.
- W4281794920 hasRelatedWork W3099516899 @default.
- W4281794920 hasVolume "248" @default.
- W4281794920 isParatext "false" @default.
- W4281794920 isRetracted "false" @default.
- W4281794920 workType "article" @default.