Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281817596> ?p ?o ?g. }
- W4281817596 endingPage "109318" @default.
- W4281817596 startingPage "109318" @default.
- W4281817596 abstract "Deposition of misfolded protein aggregates in key areas of human brain is the quintessential trait of various pertinent neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). Genetic point mutations in Cu/Zn superoxide dismutase (SOD1) are found to be the most important contributing factor behind familial ALS. Especially, single nucleotide polymorphism (SNP) A4V is the most nocuous since it substantially decreases life expectancy of patients. Besides, the use of naturally occurring polyphenolic flavonoids is profoundly being advocated for palliating amyloidogenic behavior of proteopathic proteins. In the present analysis, through proficient computational tools, we have attempted to ascertain a pharmacodynamically promising flavonoid compound that effectively curbs the pathogenic behavior of A4V SOD1 mutant. Initial screening of flavonoids that exhibit potency against amyloids identified morin, myricetin and epigallocatechin gallate as promising leads. Further, with the help of feasible and yet adept protein-ligand interaction studies and stalwart molecular simulation analyses, we were able to observe that aforementioned flavonoids were able to considerably divert mutant A4V SOD1 from its distinct pathogenic behavior. Among which, morin showed the most curative potential against A4V SOD1. Therefore, morin holds a great therapeutic potential in contriving highly efficacious inhibitors in mitigating fatal and insuperable ALS." @default.
- W4281817596 created "2022-06-13" @default.
- W4281817596 creator A5011123907 @default.
- W4281817596 creator A5014431211 @default.
- W4281817596 creator A5024414463 @default.
- W4281817596 date "2022-09-01" @default.
- W4281817596 modified "2023-09-23" @default.
- W4281817596 title "Probing the polyphenolic flavonoid, morin as a highly efficacious inhibitor against amyloid(A4V) mutant SOD1 in fatal amyotrophic lateral sclerosis" @default.
- W4281817596 cites W13899322 @default.
- W4281817596 cites W1504486296 @default.
- W4281817596 cites W1583115566 @default.
- W4281817596 cites W1948547705 @default.
- W4281817596 cites W1963537123 @default.
- W4281817596 cites W1963992886 @default.
- W4281817596 cites W1963993567 @default.
- W4281817596 cites W1964128627 @default.
- W4281817596 cites W1966078827 @default.
- W4281817596 cites W1977203247 @default.
- W4281817596 cites W1985452588 @default.
- W4281817596 cites W1987734353 @default.
- W4281817596 cites W1998275064 @default.
- W4281817596 cites W2002559713 @default.
- W4281817596 cites W2007035942 @default.
- W4281817596 cites W2008708467 @default.
- W4281817596 cites W2010777656 @default.
- W4281817596 cites W2011400432 @default.
- W4281817596 cites W2013135033 @default.
- W4281817596 cites W2013962367 @default.
- W4281817596 cites W2014286678 @default.
- W4281817596 cites W2019512396 @default.
- W4281817596 cites W2021745031 @default.
- W4281817596 cites W2025410841 @default.
- W4281817596 cites W2025994696 @default.
- W4281817596 cites W2026564199 @default.
- W4281817596 cites W2027229022 @default.
- W4281817596 cites W2027501589 @default.
- W4281817596 cites W2034293981 @default.
- W4281817596 cites W2034925108 @default.
- W4281817596 cites W2046002256 @default.
- W4281817596 cites W2048171561 @default.
- W4281817596 cites W2048695741 @default.
- W4281817596 cites W2056168344 @default.
- W4281817596 cites W2059371854 @default.
- W4281817596 cites W2059765353 @default.
- W4281817596 cites W2064367582 @default.
- W4281817596 cites W2066828509 @default.
- W4281817596 cites W2069869463 @default.
- W4281817596 cites W2076063475 @default.
- W4281817596 cites W2076159058 @default.
- W4281817596 cites W2076298803 @default.
- W4281817596 cites W2077973224 @default.
- W4281817596 cites W2079809788 @default.
- W4281817596 cites W2081260116 @default.
- W4281817596 cites W2084187244 @default.
- W4281817596 cites W2086849265 @default.
- W4281817596 cites W2089502182 @default.
- W4281817596 cites W2094309420 @default.
- W4281817596 cites W2095743707 @default.
- W4281817596 cites W2097758424 @default.
- W4281817596 cites W2101571804 @default.
- W4281817596 cites W2105668062 @default.
- W4281817596 cites W2107696550 @default.
- W4281817596 cites W2110738263 @default.
- W4281817596 cites W2119255695 @default.
- W4281817596 cites W2134731229 @default.
- W4281817596 cites W2136287158 @default.
- W4281817596 cites W2146554687 @default.
- W4281817596 cites W2147993766 @default.
- W4281817596 cites W2148297162 @default.
- W4281817596 cites W2155221045 @default.
- W4281817596 cites W2160544821 @default.
- W4281817596 cites W2167113152 @default.
- W4281817596 cites W2170529261 @default.
- W4281817596 cites W2202070586 @default.
- W4281817596 cites W2221151760 @default.
- W4281817596 cites W2255240541 @default.
- W4281817596 cites W2281234882 @default.
- W4281817596 cites W2308848840 @default.
- W4281817596 cites W2313719657 @default.
- W4281817596 cites W2469738507 @default.
- W4281817596 cites W2475133359 @default.
- W4281817596 cites W2533159259 @default.
- W4281817596 cites W2542648041 @default.
- W4281817596 cites W2565383127 @default.
- W4281817596 cites W2570634615 @default.
- W4281817596 cites W2599534399 @default.
- W4281817596 cites W2604840146 @default.
- W4281817596 cites W2606129105 @default.
- W4281817596 cites W2606142185 @default.
- W4281817596 cites W2617845766 @default.
- W4281817596 cites W2734651019 @default.
- W4281817596 cites W2753537423 @default.
- W4281817596 cites W2765285487 @default.
- W4281817596 cites W2796104968 @default.
- W4281817596 cites W2806876262 @default.
- W4281817596 cites W2809625256 @default.
- W4281817596 cites W2890247534 @default.
- W4281817596 cites W2893756940 @default.