Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281849335> ?p ?o ?g. }
- W4281849335 endingPage "3691" @default.
- W4281849335 startingPage "3679" @default.
- W4281849335 abstract "Exploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates report a rapid increase in synapse number between the late gestational period and the early neonatal period, such that synaptic density approaches adult levels by birth. Prenatal synaptic development may have an enduring impact on postnatal brain development, but precisely how synaptic density changes in utero are unknown because current methods to quantify synaptic density are invasive and require post-mortem brain tissue.We used synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) radioligands [11C]UCB-J and [18F]Syn-VesT-1 to conduct the first assessment of synaptic density in the developing fetal brain in gravid rhesus monkeys. Eight pregnant monkeys were scanned twice during the third trimester at two imaging sites. Fetal post-mortem samples were collected near term in a subset of subjects to quantify SV2A density by Western blot.Image-derived fetal brain SV2A measures increased during the third trimester. SV2A concentrations were greater in subcortical regions than in cortical regions at both gestational ages. Near term, SV2A density was higher in primary motor and visual areas than respective associative regions. Post-mortem quantification of SV2A density was significantly correlated with regional SV2A PET measures.While further study is needed to determine the exact relationship of SV2A and synaptic density, the imaging paradigm developed in the current study allows for the effective in vivo study of SV2A development in the fetal brain." @default.
- W4281849335 created "2022-06-13" @default.
- W4281849335 creator A5002932485 @default.
- W4281849335 creator A5004932337 @default.
- W4281849335 creator A5006508700 @default.
- W4281849335 creator A5011648052 @default.
- W4281849335 creator A5012357230 @default.
- W4281849335 creator A5019407934 @default.
- W4281849335 creator A5030526984 @default.
- W4281849335 creator A5041969169 @default.
- W4281849335 creator A5043106959 @default.
- W4281849335 creator A5046219145 @default.
- W4281849335 creator A5054839216 @default.
- W4281849335 creator A5057243967 @default.
- W4281849335 creator A5059496484 @default.
- W4281849335 creator A5065382331 @default.
- W4281849335 creator A5073059182 @default.
- W4281849335 creator A5073935438 @default.
- W4281849335 date "2022-05-28" @default.
- W4281849335 modified "2023-10-14" @default.
- W4281849335 title "Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)" @default.
- W4281849335 cites W1950026089 @default.
- W4281849335 cites W1968048563 @default.
- W4281849335 cites W1982528566 @default.
- W4281849335 cites W1989355184 @default.
- W4281849335 cites W1991772365 @default.
- W4281849335 cites W1995362640 @default.
- W4281849335 cites W2003052675 @default.
- W4281849335 cites W2008398629 @default.
- W4281849335 cites W2035319691 @default.
- W4281849335 cites W2039324279 @default.
- W4281849335 cites W2041791604 @default.
- W4281849335 cites W2048206030 @default.
- W4281849335 cites W2053373257 @default.
- W4281849335 cites W2054765812 @default.
- W4281849335 cites W2054929374 @default.
- W4281849335 cites W2069765655 @default.
- W4281849335 cites W2072378554 @default.
- W4281849335 cites W2077630079 @default.
- W4281849335 cites W2082642408 @default.
- W4281849335 cites W2085170165 @default.
- W4281849335 cites W2099626510 @default.
- W4281849335 cites W2105549490 @default.
- W4281849335 cites W2112633417 @default.
- W4281849335 cites W2113359311 @default.
- W4281849335 cites W2120281347 @default.
- W4281849335 cites W2122573606 @default.
- W4281849335 cites W2125138207 @default.
- W4281849335 cites W2144447780 @default.
- W4281849335 cites W2147308648 @default.
- W4281849335 cites W2155471406 @default.
- W4281849335 cites W2169602339 @default.
- W4281849335 cites W2294066296 @default.
- W4281849335 cites W2311377444 @default.
- W4281849335 cites W2493366526 @default.
- W4281849335 cites W2503767557 @default.
- W4281849335 cites W2514222651 @default.
- W4281849335 cites W2585941667 @default.
- W4281849335 cites W2762958751 @default.
- W4281849335 cites W2786873781 @default.
- W4281849335 cites W2883737562 @default.
- W4281849335 cites W2899673110 @default.
- W4281849335 cites W2922768797 @default.
- W4281849335 cites W2933363539 @default.
- W4281849335 cites W2975257318 @default.
- W4281849335 cites W2979263588 @default.
- W4281849335 cites W3025834426 @default.
- W4281849335 cites W3047307865 @default.
- W4281849335 cites W3087650764 @default.
- W4281849335 cites W3115185434 @default.
- W4281849335 cites W3131204740 @default.
- W4281849335 doi "https://doi.org/10.1007/s00259-022-05825-6" @default.
- W4281849335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35633376" @default.
- W4281849335 hasPublicationYear "2022" @default.
- W4281849335 type Work @default.
- W4281849335 citedByCount "2" @default.
- W4281849335 countsByYear W42818493352022 @default.
- W4281849335 countsByYear W42818493352023 @default.
- W4281849335 crossrefType "journal-article" @default.
- W4281849335 hasAuthorship W4281849335A5002932485 @default.
- W4281849335 hasAuthorship W4281849335A5004932337 @default.
- W4281849335 hasAuthorship W4281849335A5006508700 @default.
- W4281849335 hasAuthorship W4281849335A5011648052 @default.
- W4281849335 hasAuthorship W4281849335A5012357230 @default.
- W4281849335 hasAuthorship W4281849335A5019407934 @default.
- W4281849335 hasAuthorship W4281849335A5030526984 @default.
- W4281849335 hasAuthorship W4281849335A5041969169 @default.
- W4281849335 hasAuthorship W4281849335A5043106959 @default.
- W4281849335 hasAuthorship W4281849335A5046219145 @default.
- W4281849335 hasAuthorship W4281849335A5054839216 @default.
- W4281849335 hasAuthorship W4281849335A5057243967 @default.
- W4281849335 hasAuthorship W4281849335A5059496484 @default.
- W4281849335 hasAuthorship W4281849335A5065382331 @default.
- W4281849335 hasAuthorship W4281849335A5073059182 @default.
- W4281849335 hasAuthorship W4281849335A5073935438 @default.
- W4281849335 hasBestOaLocation W42818493352 @default.
- W4281849335 hasConcept C126322002 @default.
- W4281849335 hasConcept C130316041 @default.