Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281853475> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4281853475 abstract "An understanding of the quantitative relationship between bile canaliculus (BC) dynamics and the disruption of tight junctions (TJs) during drug-induced intrahepatic cholestasis may lead to new strategies aimed at drug development and toxicity testing. To investigate the relationship between BC dynamics and TJ disruption, we retrospectively analyzed the extent of TJ disruption in response to changes in the dynamics of BCs cultured with entacapone (ENT). Three hours after adding ENT, the ZO-1-negative BC surface area ratio became significantly higher (4.1-fold) than those of ZO-1-positive BCs. Based on these data, we calculated slopes of surface area changes, m, of each ZO-1-positive and ZO-1-negative BC. BCs with m ≤ 15 that fell within the 95% confidence interval of ZO-1-positive BCs were defined as ZO-1-positive. To validate this method, we compared the frequency of ZO-1-positive BCs, FZ , with that of BCs with m ≤ 15, FT , in culture using drugs that regulate TJ, or induce intrahepatic cholestasis. FT values were correlated with FZ under all culture conditions (R2 = .99). Our results indicate that the magnitude of BC surface area changes is a factor affecting TJ disruption, suggesting that maintaining TJ integrity by slowing BC dilation inhibits cell death." @default.
- W4281853475 created "2022-06-13" @default.
- W4281853475 creator A5005750984 @default.
- W4281853475 creator A5040106746 @default.
- W4281853475 date "2022-05-27" @default.
- W4281853475 modified "2023-09-27" @default.
- W4281853475 title "Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics" @default.
- W4281853475 cites W1493935353 @default.
- W4281853475 cites W1977293373 @default.
- W4281853475 cites W1985053217 @default.
- W4281853475 cites W2006655651 @default.
- W4281853475 cites W2011479582 @default.
- W4281853475 cites W2018323316 @default.
- W4281853475 cites W2040645020 @default.
- W4281853475 cites W2054633223 @default.
- W4281853475 cites W2068413632 @default.
- W4281853475 cites W2080578796 @default.
- W4281853475 cites W2099540110 @default.
- W4281853475 cites W2102090879 @default.
- W4281853475 cites W2105894053 @default.
- W4281853475 cites W2107601924 @default.
- W4281853475 cites W2108329371 @default.
- W4281853475 cites W2124428389 @default.
- W4281853475 cites W2136693019 @default.
- W4281853475 cites W2142112423 @default.
- W4281853475 cites W2150034964 @default.
- W4281853475 cites W2169019804 @default.
- W4281853475 cites W2285144497 @default.
- W4281853475 cites W2361216117 @default.
- W4281853475 cites W2528441510 @default.
- W4281853475 cites W2614598599 @default.
- W4281853475 cites W2769113543 @default.
- W4281853475 cites W2803000549 @default.
- W4281853475 cites W2888225088 @default.
- W4281853475 cites W2889568479 @default.
- W4281853475 cites W2963579069 @default.
- W4281853475 cites W2977427045 @default.
- W4281853475 cites W2987918752 @default.
- W4281853475 cites W3082458191 @default.
- W4281853475 cites W3121006963 @default.
- W4281853475 cites W3165049538 @default.
- W4281853475 cites W4211240480 @default.
- W4281853475 cites W4281853475 @default.
- W4281853475 doi "https://doi.org/10.1002/prp2.960" @default.
- W4281853475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35621230" @default.
- W4281853475 hasPublicationYear "2022" @default.
- W4281853475 type Work @default.
- W4281853475 citedByCount "1" @default.
- W4281853475 countsByYear W42818534752022 @default.
- W4281853475 crossrefType "journal-article" @default.
- W4281853475 hasAuthorship W4281853475A5005750984 @default.
- W4281853475 hasAuthorship W4281853475A5040106746 @default.
- W4281853475 hasBestOaLocation W42818534752 @default.
- W4281853475 hasConcept C126322002 @default.
- W4281853475 hasConcept C185592680 @default.
- W4281853475 hasConcept C2778593092 @default.
- W4281853475 hasConcept C2780035454 @default.
- W4281853475 hasConcept C71924100 @default.
- W4281853475 hasConcept C94033540 @default.
- W4281853475 hasConcept C98274493 @default.
- W4281853475 hasConceptScore W4281853475C126322002 @default.
- W4281853475 hasConceptScore W4281853475C185592680 @default.
- W4281853475 hasConceptScore W4281853475C2778593092 @default.
- W4281853475 hasConceptScore W4281853475C2780035454 @default.
- W4281853475 hasConceptScore W4281853475C71924100 @default.
- W4281853475 hasConceptScore W4281853475C94033540 @default.
- W4281853475 hasConceptScore W4281853475C98274493 @default.
- W4281853475 hasFunder F4320311405 @default.
- W4281853475 hasIssue "3" @default.
- W4281853475 hasLocation W42818534751 @default.
- W4281853475 hasLocation W42818534752 @default.
- W4281853475 hasLocation W42818534753 @default.
- W4281853475 hasOpenAccess W4281853475 @default.
- W4281853475 hasPrimaryLocation W42818534751 @default.
- W4281853475 hasRelatedWork W1966560770 @default.
- W4281853475 hasRelatedWork W2079925808 @default.
- W4281853475 hasRelatedWork W2158885741 @default.
- W4281853475 hasRelatedWork W2320082856 @default.
- W4281853475 hasRelatedWork W2335564158 @default.
- W4281853475 hasRelatedWork W2593230482 @default.
- W4281853475 hasRelatedWork W2604916107 @default.
- W4281853475 hasRelatedWork W2748952813 @default.
- W4281853475 hasRelatedWork W2899084033 @default.
- W4281853475 hasRelatedWork W385167742 @default.
- W4281853475 hasVolume "10" @default.
- W4281853475 isParatext "false" @default.
- W4281853475 isRetracted "false" @default.
- W4281853475 workType "article" @default.