FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281873009> ?p ?o ?g. }

• W4281873009 endingPage "154232" @default.
• W4281873009 startingPage "154232" @default.
• W4281873009 abstract "It remains a huge challenge to recover the intestine immune function for the treatment of intestinal mucosal damage from chemotherapy with cyclophosphamide (CY). Alhagi honey polysaccharide (AH) has immunomodulation pharmacological activity, but the effect and mechanism on the intestinal immune system of CY-mice remain unclear.In this experiment, the immunomodulatory activity of AH on intestinal immune in CY-mice and its mechanism of regulating the intestinal immune system was investigated.The experiment studied the immunomodulatory activity of AH on the intestinal immune system and its mechanism for the first time from in vitro and in vivo experiments. We investigated the immunomodulatory effects of AH on Caco-2 and dendritic cells (DCs) in vitro by using western blot (WB), flow cytometry, quantitative real-time PCR (qPCR), and ELISA methods. In vivo experiment, the immunosuppressive mouse model was established through being given intraperitoneal injection with CY (80 mg/kg) for 3 days. Then, mice oral administration of 800 mg/kg AH and 40 mg/kg levamisole hydrochloride for a week. Immunofluorescence, flow cytometry, ELISA, qPCR and WB were applied to examine the immunomodulatory activity of AH on the intestinal immune function of CY-mice, as well as the function of AH on the concentration of SCFAs in cecum by Gas chromatographic analysis.In vitro experiments, AH could significantly stimulate the expression of pIgR protein in Caco-2. It could also induce the DCs maturation and release the cytokines to regulate the immune response. In vivo experiments, AH could remarkably stimulate the DCs maturation and secrete more CCL20 to recruit DCs, then induce the T (CD4+ and CD8+) and B cells proliferation and activation. Moreover, it could further induce T helper cells to differentiate and secrete cytokines to enhance the secretion of sIgA. Furthermore, it also directly activated DCs and released cytokines to increase the content of pIgR, J-chain, and IgA+ cells in intestine, thereby enhancing the secretion of sIgA to protect the intestine. In addition, AH could obviously strengthen the SCFAs production in cecum to regulate the intestinal immune dysfunction induced by CY.In summary, oral administrated AH exhibits great benefits for treating CY-induced intestinal immunosuppression, and the mechanism of action mainly involves sIgA, DCs, SCFAs." @default.
• W4281873009 created "2022-06-13" @default.
• W4281873009 creator A5013972461 @default.
• W4281873009 creator A5015515454 @default.
• W4281873009 creator A5046463494 @default.
• W4281873009 creator A5049293174 @default.
• W4281873009 creator A5049692788 @default.
• W4281873009 creator A5065692955 @default.
• W4281873009 creator A5067341225 @default.
• W4281873009 creator A5089273861 @default.
• W4281873009 date "2022-08-01" @default.
• W4281873009 modified "2023-10-15" @default.
• W4281873009 title "The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides" @default.
• W4281873009 cites W1584203472 @default.
• W4281873009 cites W1751404917 @default.
• W4281873009 cites W1988170203 @default.
• W4281873009 cites W1990236675 @default.
• W4281873009 cites W1992744849 @default.
• W4281873009 cites W1993150792 @default.
• W4281873009 cites W2016825203 @default.
• W4281873009 cites W2021054542 @default.
• W4281873009 cites W2033877575 @default.
• W4281873009 cites W2047481286 @default.
• W4281873009 cites W2059502200 @default.
• W4281873009 cites W2061856892 @default.
• W4281873009 cites W2065661920 @default.
• W4281873009 cites W2107235439 @default.
• W4281873009 cites W2116763454 @default.
• W4281873009 cites W2125378344 @default.
• W4281873009 cites W2210295781 @default.
• W4281873009 cites W2335996377 @default.
• W4281873009 cites W2415130844 @default.
• W4281873009 cites W2590387708 @default.
• W4281873009 cites W2609972212 @default.
• W4281873009 cites W2779382441 @default.
• W4281873009 cites W2886690355 @default.
• W4281873009 cites W2900055444 @default.
• W4281873009 cites W2911438199 @default.
• W4281873009 cites W2913118285 @default.
• W4281873009 cites W2921191661 @default.
• W4281873009 cites W2921966151 @default.
• W4281873009 cites W2969512896 @default.
• W4281873009 cites W2974958913 @default.
• W4281873009 cites W2981229648 @default.
• W4281873009 cites W3005498230 @default.
• W4281873009 cites W3092842569 @default.
• W4281873009 cites W3166271220 @default.
• W4281873009 cites W3192113961 @default.
• W4281873009 doi "https://doi.org/10.1016/j.phymed.2022.154232" @default.
• W4281873009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35675749" @default.
• W4281873009 hasPublicationYear "2022" @default.
• W4281873009 type Work @default.
• W4281873009 citedByCount "4" @default.
• W4281873009 countsByYear W42818730092023 @default.
• W4281873009 crossrefType "journal-article" @default.
• W4281873009 hasAuthorship W4281873009A5013972461 @default.
• W4281873009 hasAuthorship W4281873009A5015515454 @default.
• W4281873009 hasAuthorship W4281873009A5046463494 @default.
• W4281873009 hasAuthorship W4281873009A5049293174 @default.
• W4281873009 hasAuthorship W4281873009A5049692788 @default.
• W4281873009 hasAuthorship W4281873009A5065692955 @default.
• W4281873009 hasAuthorship W4281873009A5067341225 @default.
• W4281873009 hasAuthorship W4281873009A5089273861 @default.
• W4281873009 hasConcept C150903083 @default.
• W4281873009 hasConcept C185592680 @default.
• W4281873009 hasConcept C203014093 @default.
• W4281873009 hasConcept C207001950 @default.
• W4281873009 hasConcept C2778019737 @default.
• W4281873009 hasConcept C49039625 @default.
• W4281873009 hasConcept C553184892 @default.
• W4281873009 hasConcept C55493867 @default.
• W4281873009 hasConcept C86803240 @default.
• W4281873009 hasConcept C8891405 @default.
• W4281873009 hasConcept C98274493 @default.
• W4281873009 hasConceptScore W4281873009C150903083 @default.
• W4281873009 hasConceptScore W4281873009C185592680 @default.
• W4281873009 hasConceptScore W4281873009C203014093 @default.
• W4281873009 hasConceptScore W4281873009C207001950 @default.
• W4281873009 hasConceptScore W4281873009C2778019737 @default.
• W4281873009 hasConceptScore W4281873009C49039625 @default.
• W4281873009 hasConceptScore W4281873009C553184892 @default.
• W4281873009 hasConceptScore W4281873009C55493867 @default.
• W4281873009 hasConceptScore W4281873009C86803240 @default.
• W4281873009 hasConceptScore W4281873009C8891405 @default.
• W4281873009 hasConceptScore W4281873009C98274493 @default.
• W4281873009 hasFunder F4320321001 @default.
• W4281873009 hasFunder F4320325211 @default.
• W4281873009 hasFunder F4320327518 @default.
• W4281873009 hasFunder F4320335787 @default.
• W4281873009 hasLocation W42818730091 @default.
• W4281873009 hasLocation W42818730092 @default.
• W4281873009 hasOpenAccess W4281873009 @default.
• W4281873009 hasPrimaryLocation W42818730091 @default.
• W4281873009 hasRelatedWork W1968701816 @default.
• W4281873009 hasRelatedWork W2021792849 @default.
• W4281873009 hasRelatedWork W2065284647 @default.
• W4281873009 hasRelatedWork W2152260884 @default.
• W4281873009 hasRelatedWork W2152471247 @default.

• next