Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281873652> ?p ?o ?g. }
- W4281873652 abstract "Abstract Biomolecular condensates require suitable control of material properties for their function. Here we apply Differential Dynamic Microscopy (DDM) to probe the material properties of an in vitro model of processing bodies consisting of out-of-equilibrium condensates formed by the DEAD-box ATPase Dhh1 in the presence of ATP and RNA. By applying this single-droplet technique we show that condensates within the same population exhibit a distribution of material properties, which are regulated on several levels. Removal of the low-complexity domains (LCDs) of the protein decreases the fluidity of the condensates. Structured RNA leads to a larger fraction of dynamically arrested condensates with respect to unstructured polyuridylic acid (polyU). Promotion of the enzymatic ATPase activity of Dhh1 reduces aging of the condensates and the formation of arrested structures, indicating that biochemical activity and material turnover can maintain fluid-like properties over time." @default.
- W4281873652 created "2022-06-13" @default.
- W4281873652 creator A5031188442 @default.
- W4281873652 creator A5034404743 @default.
- W4281873652 creator A5035220965 @default.
- W4281873652 creator A5049295836 @default.
- W4281873652 creator A5079941673 @default.
- W4281873652 creator A5081005940 @default.
- W4281873652 date "2022-05-31" @default.
- W4281873652 modified "2023-10-17" @default.
- W4281873652 title "Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity" @default.
- W4281873652 cites W1854281301 @default.
- W4281873652 cites W1912455695 @default.
- W4281873652 cites W1952608303 @default.
- W4281873652 cites W1976572669 @default.
- W4281873652 cites W1996157637 @default.
- W4281873652 cites W2021675528 @default.
- W4281873652 cites W2039885485 @default.
- W4281873652 cites W2051275283 @default.
- W4281873652 cites W2054352933 @default.
- W4281873652 cites W2062289554 @default.
- W4281873652 cites W2068868065 @default.
- W4281873652 cites W2073634930 @default.
- W4281873652 cites W2085978470 @default.
- W4281873652 cites W2089712921 @default.
- W4281873652 cites W2092816494 @default.
- W4281873652 cites W2111796925 @default.
- W4281873652 cites W2139167484 @default.
- W4281873652 cites W2150860983 @default.
- W4281873652 cites W2168639701 @default.
- W4281873652 cites W2169588141 @default.
- W4281873652 cites W2292279843 @default.
- W4281873652 cites W2313094648 @default.
- W4281873652 cites W2403997508 @default.
- W4281873652 cites W2501424458 @default.
- W4281873652 cites W2527809167 @default.
- W4281873652 cites W2544297969 @default.
- W4281873652 cites W2590568317 @default.
- W4281873652 cites W2615607456 @default.
- W4281873652 cites W2620662403 @default.
- W4281873652 cites W2625742743 @default.
- W4281873652 cites W2776559018 @default.
- W4281873652 cites W2785420592 @default.
- W4281873652 cites W2788827529 @default.
- W4281873652 cites W2797356047 @default.
- W4281873652 cites W2803795590 @default.
- W4281873652 cites W2805950056 @default.
- W4281873652 cites W2854081253 @default.
- W4281873652 cites W2886239953 @default.
- W4281873652 cites W2887353309 @default.
- W4281873652 cites W2889922560 @default.
- W4281873652 cites W2891024355 @default.
- W4281873652 cites W2893743826 @default.
- W4281873652 cites W2898777420 @default.
- W4281873652 cites W2907972520 @default.
- W4281873652 cites W2916646997 @default.
- W4281873652 cites W2920659730 @default.
- W4281873652 cites W2951283121 @default.
- W4281873652 cites W2963051452 @default.
- W4281873652 cites W2966653897 @default.
- W4281873652 cites W2969343565 @default.
- W4281873652 cites W2969788883 @default.
- W4281873652 cites W3003547858 @default.
- W4281873652 cites W3016762840 @default.
- W4281873652 cites W3022721113 @default.
- W4281873652 cites W3033847448 @default.
- W4281873652 cites W3045825789 @default.
- W4281873652 cites W3048230065 @default.
- W4281873652 cites W3091506997 @default.
- W4281873652 cites W3098313728 @default.
- W4281873652 cites W3099299356 @default.
- W4281873652 cites W3111059218 @default.
- W4281873652 cites W3111523618 @default.
- W4281873652 cites W3124178049 @default.
- W4281873652 cites W3127845412 @default.
- W4281873652 cites W3201780883 @default.
- W4281873652 cites W3206262062 @default.
- W4281873652 cites W3211436564 @default.
- W4281873652 cites W4229888280 @default.
- W4281873652 cites W4361807534 @default.
- W4281873652 doi "https://doi.org/10.1038/s41467-022-30521-2" @default.
- W4281873652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35641495" @default.
- W4281873652 hasPublicationYear "2022" @default.
- W4281873652 type Work @default.
- W4281873652 citedByCount "23" @default.
- W4281873652 countsByYear W42818736522022 @default.
- W4281873652 countsByYear W42818736522023 @default.
- W4281873652 crossrefType "journal-article" @default.
- W4281873652 hasAuthorship W4281873652A5031188442 @default.
- W4281873652 hasAuthorship W4281873652A5034404743 @default.
- W4281873652 hasAuthorship W4281873652A5035220965 @default.
- W4281873652 hasAuthorship W4281873652A5049295836 @default.
- W4281873652 hasAuthorship W4281873652A5079941673 @default.
- W4281873652 hasAuthorship W4281873652A5081005940 @default.
- W4281873652 hasBestOaLocation W42818736521 @default.
- W4281873652 hasConcept C104317684 @default.
- W4281873652 hasConcept C12554922 @default.
- W4281873652 hasConcept C144024400 @default.
- W4281873652 hasConcept C149923435 @default.
- W4281873652 hasConcept C181199279 @default.