FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281885946> ?p ?o ?g. }

• W4281885946 abstract "Abstract RNA viruses generate non-standard viral genomes during their replication, including viral genomes of the copy-back (cbVG) type that cannot replicate in the absence of a standard virus. cbVGs play a crucial role in shaping virus infection outcomes due to their ability to interfere with virus replication and induce strong immune responses. However, despite their critical role during infection, the principles that drive the selection and evolution of cbVGs within a virus population are poorly understood. As cbVGs are dependent on the virus replication machinery to be generated and replicated, we hypothesized that host factors that affect virus replication exert selective pressure on cbVGs and drive their evolution within a virus population. To test this hypothesis, we used respiratory syncytial virus (RSV) as model and took an experimental evolution approach by serially passaging RSV in immune competent A549 control and immune deficient A549 STAT1 KO cells which allow higher levels of virus replication. As predicted, we observed that virus populations accumulated higher amounts of cbVGs in the more permissive A549 STAT1 KO cells over time but, unexpectedly, the predominant cbVG species after passages in the two conditions were different. While A549 STAT1 KO cells accumulated relatively short cbVGs, A549 control cells mainly contained cbVGs of much longer predicted size that have not been described previously. These long cbVGs were predominant at first in both cell lines in vitro and the predominant ones observed in samples from RSV infected patients. Although sustained high replication levels are associated with cbVG generation and accumulation, our data show that sustained high levels of virus replication are critical for cbVG population diversification, a process that preceded the generation of shorter cbVGs that selectively accumulated over time. Taken together, we show that selection and evolution of cbVGs within a virus population is shaped by how resistant or permissive a host is to RSV." @default.
• W4281885946 created "2022-06-13" @default.
• W4281885946 creator A5054604797 @default.
• W4281885946 creator A5058399472 @default.
• W4281885946 creator A5063646666 @default.
• W4281885946 creator A5077958192 @default.
• W4281885946 date "2022-05-26" @default.
• W4281885946 modified "2023-09-27" @default.
• W4281885946 title "Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selection" @default.
• W4281885946 cites W1478284728 @default.
• W4281885946 cites W1503954356 @default.
• W4281885946 cites W1541399456 @default.
• W4281885946 cites W156352715 @default.
• W4281885946 cites W1690886584 @default.
• W4281885946 cites W1778861434 @default.
• W4281885946 cites W1841329200 @default.
• W4281885946 cites W1966043283 @default.
• W4281885946 cites W1978903086 @default.
• W4281885946 cites W1992109232 @default.
• W4281885946 cites W1992741789 @default.
• W4281885946 cites W2011507014 @default.
• W4281885946 cites W2026127534 @default.
• W4281885946 cites W2031208393 @default.
• W4281885946 cites W2031837694 @default.
• W4281885946 cites W2038630105 @default.
• W4281885946 cites W2044871811 @default.
• W4281885946 cites W2060616257 @default.
• W4281885946 cites W2068672631 @default.
• W4281885946 cites W2082190650 @default.
• W4281885946 cites W2084782326 @default.
• W4281885946 cites W2096238088 @default.
• W4281885946 cites W2105611306 @default.
• W4281885946 cites W2116054283 @default.
• W4281885946 cites W2119465766 @default.
• W4281885946 cites W2162250600 @default.
• W4281885946 cites W2164010572 @default.
• W4281885946 cites W2165232178 @default.
• W4281885946 cites W2172337369 @default.
• W4281885946 cites W2173211537 @default.
• W4281885946 cites W2174649676 @default.
• W4281885946 cites W2178021319 @default.
• W4281885946 cites W2335595878 @default.
• W4281885946 cites W2527447535 @default.
• W4281885946 cites W2610451542 @default.
• W4281885946 cites W2620907542 @default.
• W4281885946 cites W2739679073 @default.
• W4281885946 cites W2750676240 @default.
• W4281885946 cites W2762066873 @default.
• W4281885946 cites W2808070694 @default.
• W4281885946 cites W2883561599 @default.
• W4281885946 cites W2900584728 @default.
• W4281885946 cites W2931678155 @default.
• W4281885946 cites W2936162970 @default.
• W4281885946 cites W2945572186 @default.
• W4281885946 cites W2947623422 @default.
• W4281885946 cites W2948601199 @default.
• W4281885946 cites W2950886086 @default.
• W4281885946 cites W3007020432 @default.
• W4281885946 cites W3016894382 @default.
• W4281885946 cites W3084860989 @default.
• W4281885946 cites W3111098509 @default.
• W4281885946 cites W3125396223 @default.
• W4281885946 cites W3139937866 @default.
• W4281885946 cites W3158082184 @default.
• W4281885946 cites W3170510495 @default.
• W4281885946 cites W3200553375 @default.
• W4281885946 cites W4220730709 @default.
• W4281885946 cites W4225367610 @default.
• W4281885946 doi "https://doi.org/10.1101/2022.05.25.493350" @default.
• W4281885946 hasPublicationYear "2022" @default.
• W4281885946 type Work @default.
• W4281885946 citedByCount "0" @default.
• W4281885946 crossrefType "posted-content" @default.
• W4281885946 hasAuthorship W4281885946A5054604797 @default.
• W4281885946 hasAuthorship W4281885946A5058399472 @default.
• W4281885946 hasAuthorship W4281885946A5063646666 @default.
• W4281885946 hasAuthorship W4281885946A5077958192 @default.
• W4281885946 hasBestOaLocation W42818859461 @default.
• W4281885946 hasConcept C104317684 @default.
• W4281885946 hasConcept C140704245 @default.
• W4281885946 hasConcept C141231307 @default.
• W4281885946 hasConcept C144024400 @default.
• W4281885946 hasConcept C14500911 @default.
• W4281885946 hasConcept C149923435 @default.
• W4281885946 hasConcept C159047783 @default.
• W4281885946 hasConcept C2522874641 @default.
• W4281885946 hasConcept C2776408679 @default.
• W4281885946 hasConcept C2908647359 @default.
• W4281885946 hasConcept C54355233 @default.
• W4281885946 hasConcept C58475186 @default.
• W4281885946 hasConcept C86803240 @default.
• W4281885946 hasConcept C8769409 @default.
• W4281885946 hasConcept C8891405 @default.
• W4281885946 hasConceptScore W4281885946C104317684 @default.
• W4281885946 hasConceptScore W4281885946C140704245 @default.
• W4281885946 hasConceptScore W4281885946C141231307 @default.
• W4281885946 hasConceptScore W4281885946C144024400 @default.
• W4281885946 hasConceptScore W4281885946C14500911 @default.
• W4281885946 hasConceptScore W4281885946C149923435 @default.
• W4281885946 hasConceptScore W4281885946C159047783 @default.

• next