Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281898083> ?p ?o ?g. }
- W4281898083 endingPage "104634" @default.
- W4281898083 startingPage "104634" @default.
- W4281898083 abstract "A major pathological mechanism involved in vascular remodeling diseases is the proliferation and migration of vascular smooth muscle cells. The lipid distribution of golden hamsters is similar to that of humans, which makes them an excellent study model for studying the pathogenesis and molecular characteristics of vascular remodeling diseases. We performed proteomic analysis on Sprague Dawley rat VSMCs (rVSMCs) and restenosis hamsters with low-density lipoprotein receptor (LDLR) deficiency as part of this study. We have also performed the enrichment analysis of differentially modified proteins in regards to Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and protein domain. 1070 differentially abundant proteins were assessed in rVSMCs before and after platelet-derived growth factor-BB (PDGF-BB) stimulation. Specifically, 1246 proteins displayed significant differences in the restenosis model in LDLR-deficient hamsters. An analysis of crosstalk between LDLR +/− hamsters artery restenosis and proliferating rVSMCs revealed 130 differentially expressed proteins, including 67 up-regulated proteins and 63 downregulated proteins. Enrichment analysis with KEGG showed differential proteins to be mainly concentrated in metabolic pathways. There are numerous differentially abundant proteins but particularly two proteins (phosphofructokinase 1 of liver type and lactate dehydrogenase A) were found to be up-regulated by PDGF-BB stimulation of rVSMCs and in a restenosis model of hamsters with LDLR +/− expression. Based on bioinformatics, we have found glycolysis pathway plays an important role in both the LDLR +/− hamsters restenosis model and the proliferation of rVSMCs. Some key glycolysis enzymes may likely be developed either as new biomarkers or drug targets for vascular remodeling diseases. • In rVSMCs, 1070 differentially rich proteins were detected by proteomics after PDGF-BB stimulation. • There were 1246 differentially rich proteins in the restenosis model in LDLR-deficient hamsters. • PFKL and LDHA play an important role in the development of vascular remodeling diseases." @default.
- W4281898083 created "2022-06-13" @default.
- W4281898083 creator A5009903472 @default.
- W4281898083 creator A5012749274 @default.
- W4281898083 creator A5033917094 @default.
- W4281898083 creator A5067078270 @default.
- W4281898083 creator A5084080939 @default.
- W4281898083 date "2022-07-01" @default.
- W4281898083 modified "2023-09-24" @default.
- W4281898083 title "Proteomics of restenosis model in LDLR-deficient hamsters coupled with the proliferative rat vascular smooth muscle cells reveals a new mechanism of vascular remodeling diseases" @default.
- W4281898083 cites W1992491122 @default.
- W4281898083 cites W2009280040 @default.
- W4281898083 cites W2016401339 @default.
- W4281898083 cites W2017155684 @default.
- W4281898083 cites W2051601828 @default.
- W4281898083 cites W2056355507 @default.
- W4281898083 cites W2056499061 @default.
- W4281898083 cites W2060081607 @default.
- W4281898083 cites W2096135094 @default.
- W4281898083 cites W2106313387 @default.
- W4281898083 cites W2109982451 @default.
- W4281898083 cites W2129033842 @default.
- W4281898083 cites W2131037987 @default.
- W4281898083 cites W2307197173 @default.
- W4281898083 cites W2370078036 @default.
- W4281898083 cites W2489887948 @default.
- W4281898083 cites W2589623897 @default.
- W4281898083 cites W2591302770 @default.
- W4281898083 cites W2595645464 @default.
- W4281898083 cites W2601487511 @default.
- W4281898083 cites W2607368894 @default.
- W4281898083 cites W2623732680 @default.
- W4281898083 cites W2681423464 @default.
- W4281898083 cites W2697742764 @default.
- W4281898083 cites W2734717774 @default.
- W4281898083 cites W2745703247 @default.
- W4281898083 cites W2762363211 @default.
- W4281898083 cites W2767340200 @default.
- W4281898083 cites W2773721653 @default.
- W4281898083 cites W2786784128 @default.
- W4281898083 cites W2790486637 @default.
- W4281898083 cites W2794080343 @default.
- W4281898083 cites W2794323786 @default.
- W4281898083 cites W2806333724 @default.
- W4281898083 cites W2810368020 @default.
- W4281898083 cites W2889776411 @default.
- W4281898083 cites W2891362794 @default.
- W4281898083 cites W2899326228 @default.
- W4281898083 cites W2900166571 @default.
- W4281898083 cites W2902246840 @default.
- W4281898083 cites W2946659622 @default.
- W4281898083 cites W2955108563 @default.
- W4281898083 cites W2966643586 @default.
- W4281898083 cites W2974947056 @default.
- W4281898083 cites W2984323265 @default.
- W4281898083 cites W2994749187 @default.
- W4281898083 cites W2995974320 @default.
- W4281898083 cites W2997525274 @default.
- W4281898083 cites W3003299879 @default.
- W4281898083 cites W3004414073 @default.
- W4281898083 cites W3021299040 @default.
- W4281898083 cites W3025583530 @default.
- W4281898083 cites W3035124409 @default.
- W4281898083 doi "https://doi.org/10.1016/j.jprot.2022.104634" @default.
- W4281898083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35661764" @default.
- W4281898083 hasPublicationYear "2022" @default.
- W4281898083 type Work @default.
- W4281898083 citedByCount "1" @default.
- W4281898083 countsByYear W42818980832022 @default.
- W4281898083 crossrefType "journal-article" @default.
- W4281898083 hasAuthorship W4281898083A5009903472 @default.
- W4281898083 hasAuthorship W4281898083A5012749274 @default.
- W4281898083 hasAuthorship W4281898083A5033917094 @default.
- W4281898083 hasAuthorship W4281898083A5067078270 @default.
- W4281898083 hasAuthorship W4281898083A5084080939 @default.
- W4281898083 hasConcept C104317684 @default.
- W4281898083 hasConcept C104397665 @default.
- W4281898083 hasConcept C134018914 @default.
- W4281898083 hasConcept C150194340 @default.
- W4281898083 hasConcept C152724338 @default.
- W4281898083 hasConcept C162317418 @default.
- W4281898083 hasConcept C2778163477 @default.
- W4281898083 hasConcept C2779395532 @default.
- W4281898083 hasConcept C2780072125 @default.
- W4281898083 hasConcept C2780394083 @default.
- W4281898083 hasConcept C2992686903 @default.
- W4281898083 hasConcept C43554185 @default.
- W4281898083 hasConcept C46111723 @default.
- W4281898083 hasConcept C502942594 @default.
- W4281898083 hasConcept C55493867 @default.
- W4281898083 hasConcept C62478195 @default.
- W4281898083 hasConcept C86803240 @default.
- W4281898083 hasConcept C95444343 @default.
- W4281898083 hasConceptScore W4281898083C104317684 @default.
- W4281898083 hasConceptScore W4281898083C104397665 @default.
- W4281898083 hasConceptScore W4281898083C134018914 @default.
- W4281898083 hasConceptScore W4281898083C150194340 @default.
- W4281898083 hasConceptScore W4281898083C152724338 @default.