FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281914495> ?p ?o ?g. }

• W4281914495 abstract "Abstract Adverse childhood experiences (ACEs) are traumatic events during the first years of life that are associated with a higher risk of developing cardiovascular disease (CVD) during adulthood. The medial prefrontal cortex (mPFC) is a core region in the brain that modulates emotions and is directly involved in the cardiovascular response to stress by increasing vascular resistance. In the present study we examined the relationship between ACEs, mPFC and peripheral vascular function. Forty-five, adults (33±5 yrs.) participated in the present study to evaluate cerebral hemodynamics and peripheral vascular function. The impact of adverse experiences was evaluated through the ACE questionnaire. Among those that experienced ACEs (ACE group, n = 22), there was a significantly (P &lt; 0.001) reduced activation of the mPFC as well as greater peripheral vascular resistance observed in the small (P ≤ 0.035), conduit (P ≤ 0.042) and large (P ≤ 0.001) blood vessels, when compared to those that did not report ACEs (Control group, n = 23). In addition, relationships between the number of ACEs and mPFC activation (rs = −0.428; P = 0.003) and peripheral vascular function (rs≤ −0.373; P ≤ 0.009) were observed. Findings from the present study support that adults who experienced ACEs exhibit a reduced activation of the mPFC along with systemic vascular dysfunction. In addition, individuals exposed to more childhood traumatic events exhibited a progressively greater inactivation of the mPFC and an increased peripheral vasoconstriction in a dose-dependent manner. These findings provide novel insights into the potential role that the brain and the peripheral vasculature may have in connecting adverse childhood events to the increased risk of CVD." @default.
• W4281914495 created "2022-06-13" @default.
• W4281914495 creator A5003642259 @default.
• W4281914495 creator A5020554836 @default.
• W4281914495 creator A5036809487 @default.
• W4281914495 creator A5046609778 @default.
• W4281914495 creator A5072145334 @default.
• W4281914495 creator A5072173764 @default.
• W4281914495 date "2022-01-01" @default.
• W4281914495 modified "2023-10-05" @default.
• W4281914495 title "The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature" @default.
• W4281914495 cites W1763274674 @default.
• W4281914495 cites W1966117108 @default.
• W4281914495 cites W1971639265 @default.
• W4281914495 cites W1972154151 @default.
• W4281914495 cites W1978489779 @default.
• W4281914495 cites W1981459575 @default.
• W4281914495 cites W1982286843 @default.
• W4281914495 cites W1987375729 @default.
• W4281914495 cites W2003041135 @default.
• W4281914495 cites W2007516104 @default.
• W4281914495 cites W2007554378 @default.
• W4281914495 cites W2016913364 @default.
• W4281914495 cites W2023878276 @default.
• W4281914495 cites W2042423096 @default.
• W4281914495 cites W2044259294 @default.
• W4281914495 cites W2046186201 @default.
• W4281914495 cites W2077878361 @default.
• W4281914495 cites W2086146798 @default.
• W4281914495 cites W2088639163 @default.
• W4281914495 cites W2091181219 @default.
• W4281914495 cites W2098156671 @default.
• W4281914495 cites W2101939606 @default.
• W4281914495 cites W2103678921 @default.
• W4281914495 cites W2111637379 @default.
• W4281914495 cites W2116839388 @default.
• W4281914495 cites W2117026208 @default.
• W4281914495 cites W2117501598 @default.
• W4281914495 cites W2117828851 @default.
• W4281914495 cites W2127180883 @default.
• W4281914495 cites W2130838343 @default.
• W4281914495 cites W2134192460 @default.
• W4281914495 cites W2137070227 @default.
• W4281914495 cites W2137811349 @default.
• W4281914495 cites W2138209376 @default.
• W4281914495 cites W2141141027 @default.
• W4281914495 cites W2149257689 @default.
• W4281914495 cites W2151027504 @default.
• W4281914495 cites W2159252734 @default.
• W4281914495 cites W2168084483 @default.
• W4281914495 cites W2179667358 @default.
• W4281914495 cites W2275060080 @default.
• W4281914495 cites W2338590126 @default.
• W4281914495 cites W2344726245 @default.
• W4281914495 cites W2414963831 @default.
• W4281914495 cites W2545669894 @default.
• W4281914495 cites W2575516020 @default.
• W4281914495 cites W2595998053 @default.
• W4281914495 cites W2600286291 @default.
• W4281914495 cites W2759931451 @default.
• W4281914495 cites W2780541235 @default.
• W4281914495 cites W2895158858 @default.
• W4281914495 cites W2921355666 @default.
• W4281914495 cites W2948026549 @default.
• W4281914495 cites W2955955844 @default.
• W4281914495 cites W3019036747 @default.
• W4281914495 cites W3028421748 @default.
• W4281914495 cites W3102389263 @default.
• W4281914495 cites W3184772494 @default.
• W4281914495 doi "https://doi.org/10.1093/function/zqac029" @default.
• W4281914495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35774591" @default.
• W4281914495 hasPublicationYear "2022" @default.
• W4281914495 type Work @default.
• W4281914495 citedByCount "3" @default.
• W4281914495 countsByYear W42819144952022 @default.
• W4281914495 countsByYear W42819144952023 @default.
• W4281914495 crossrefType "journal-article" @default.
• W4281914495 hasAuthorship W4281914495A5003642259 @default.
• W4281914495 hasAuthorship W4281914495A5020554836 @default.
• W4281914495 hasAuthorship W4281914495A5036809487 @default.
• W4281914495 hasAuthorship W4281914495A5046609778 @default.
• W4281914495 hasAuthorship W4281914495A5072145334 @default.
• W4281914495 hasAuthorship W4281914495A5072173764 @default.
• W4281914495 hasBestOaLocation W42819144951 @default.
• W4281914495 hasConcept C118552586 @default.
• W4281914495 hasConcept C126322002 @default.
• W4281914495 hasConcept C164705383 @default.
• W4281914495 hasConcept C169900460 @default.
• W4281914495 hasConcept C178853913 @default.
• W4281914495 hasConcept C2777466421 @default.
• W4281914495 hasConcept C2779134260 @default.
• W4281914495 hasConcept C2779961880 @default.
• W4281914495 hasConcept C2781195155 @default.
• W4281914495 hasConcept C46762472 @default.
• W4281914495 hasConcept C58245268 @default.
• W4281914495 hasConcept C71924100 @default.
• W4281914495 hasConceptScore W4281914495C118552586 @default.
• W4281914495 hasConceptScore W4281914495C126322002 @default.
• W4281914495 hasConceptScore W4281914495C164705383 @default.
• W4281914495 hasConceptScore W4281914495C169900460 @default.

• next