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- W4281914862 abstract "Abstract Purpose Early diagnosis of GDM and targeted blood glucose control treatment are crucial to improve maternal and infant health and to reduce the incidence of adverse pregnancy events. There is a lack of simple, effective and accurate screening methods that can be performed before 14 weeks of gestation. This study aimed to investigate the value of hemodynamic parameters of spiral artery in predicting GDM at 11 ~ 13 + 6 weeks of gestation. Methods To investigate the value of hemodynamic parameters of uterine spiral artery in predicting GDM in first trimester. We conducted a prospective case–control study, involving 1054 singleton pregnancies in our obstetric clinic of Shanghai First Maternal and Infant Hospital from January 2020 to June 2021. According to the follow-up results, they were divided into normal group (938 cases) and GDM group (116 cases). All pregnant women examined by Doppler ultrasonography in first-trimester to measure uterine spiral arterial hemodynamic parameters, including pulsation index (PI), resistance index (RI), peak systolic flow velocity (PSV) and mean diastolic velocity(MDV). The hemodynamic parameters of the GDM group and normal group were compared, and ROC curve was drawn to evaluate the efficacy of uterine spiral artery PI in predicting GDM. Results The PI value of uterine spiral artery in GDM group was higher than that in normal group (0.88 ± 0.16 vs. 0.63 ± 0.17), and the difference was statistically significant (t = 14.932, P < 0.05). The PSV and RI in GDM group were slightly lower than those in normal group, but the differences were not statistically significant (P > 0.05). The area under ROC curve of spiral artery PI for predicting GDM was 0.861 (95%CI: 0.827–0.895, P < 0.05), and PI 0.675 was the optimal threshold. The sensitivity and specificity of spiral artery PI for predicting GDM were 90.5% and73.3%, respectively. Conclusions: The changes of uterine spiral artery hemodynamic parameters at first-trimester of pregnancy may be related to the occurrence of GDM, and the PI value of uterine spiral artery has certain value in predicting GDM." @default.
- W4281914862 created "2022-06-13" @default.
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- W4281914862 date "2022-05-31" @default.
- W4281914862 modified "2023-09-27" @default.
- W4281914862 title "The value of hemodynamic parameters of uterine spiral arteries in predicting Gestational Diabetes Mellitus in first trimester" @default.
- W4281914862 doi "https://doi.org/10.21203/rs.3.rs-1632025/v1" @default.
- W4281914862 hasPublicationYear "2022" @default.
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