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- W4281917085 startingPage "1615" @default.
- W4281917085 abstract "Evidence has shown that DNA is a pathogen-associated molecular pattern, posing a unique challenge in the discrimination between endogenous and foreign DNA. This challenge is highlighted by certain autoinflammatory diseases that arise from monogenic mutations and result in periodic flares of inflammation, typically in the absence of autoantibodies or antigen-specific T lymphocytes. Several autoinflammatory diseases arise due to mutations in genes that normally prevent the accrual of endogenous DNA or are due to mutations that cause activation of intracellular DNA-sensing pathway components. Evidence from genetically modified murine models further support an ability of endogenous DNA and DNA sensing to drive disease pathogenesis, prompting the question of whether endogenous DNA can also induce inflammation in human autoimmune diseases. In this review, we discuss the current understanding of intracellular DNA sensing and downstream signaling pathways as they pertain to autoinflammatory disease, including the development of monogenic disorders such as Stimulator of interferon genes-associated vasculopathy with onset in infancy and Aicardi-Goutières syndrome. In addition, we discuss systemic rheumatic diseases, including certain forms of systemic lupus erythematosus, familial chilblain lupus, and other diseases with established links to intracellular DNA-sensing pathways, and highlight the lessons learned from these examples as they apply to the development of therapies targeting these pathways." @default.
- W4281917085 created "2022-06-13" @default.
- W4281917085 creator A5024038808 @default.
- W4281917085 creator A5043237777 @default.
- W4281917085 creator A5046186975 @default.
- W4281917085 date "2022-09-06" @default.
- W4281917085 modified "2023-10-17" @default.
- W4281917085 title "Intracellular Sensing of <scp>DNA</scp> in Autoinflammation and Autoimmunity" @default.
- W4281917085 cites W1498368498 @default.
- W4281917085 cites W1567114372 @default.
- W4281917085 cites W1857174086 @default.
- W4281917085 cites W1896868877 @default.
- W4281917085 cites W1964510574 @default.
- W4281917085 cites W1968178474 @default.
- W4281917085 cites W1969888906 @default.
- W4281917085 cites W1975215291 @default.
- W4281917085 cites W1985891126 @default.
- W4281917085 cites W1986572373 @default.
- W4281917085 cites W1987609001 @default.
- W4281917085 cites W1993832002 @default.
- W4281917085 cites W2015310325 @default.
- W4281917085 cites W2043959346 @default.
- W4281917085 cites W2047365750 @default.
- W4281917085 cites W2051317205 @default.
- W4281917085 cites W2057539094 @default.
- W4281917085 cites W2075172390 @default.
- W4281917085 cites W2075688750 @default.
- W4281917085 cites W2076690763 @default.
- W4281917085 cites W2106146127 @default.
- W4281917085 cites W2109491705 @default.
- W4281917085 cites W2116778443 @default.
- W4281917085 cites W2124451653 @default.
- W4281917085 cites W2127200072 @default.
- W4281917085 cites W2145812105 @default.
- W4281917085 cites W2146230109 @default.
- W4281917085 cites W2153833981 @default.
- W4281917085 cites W2154171253 @default.
- W4281917085 cites W2167317609 @default.
- W4281917085 cites W2168252967 @default.
- W4281917085 cites W2171946670 @default.
- W4281917085 cites W2201964113 @default.
- W4281917085 cites W2513620161 @default.
- W4281917085 cites W2513658500 @default.
- W4281917085 cites W2555847150 @default.
- W4281917085 cites W2570842995 @default.
- W4281917085 cites W2596815322 @default.
- W4281917085 cites W2600037598 @default.
- W4281917085 cites W2601660331 @default.
- W4281917085 cites W2758637781 @default.
- W4281917085 cites W2764139712 @default.
- W4281917085 cites W2774351255 @default.
- W4281917085 cites W2803376047 @default.
- W4281917085 cites W2804533550 @default.
- W4281917085 cites W2809821375 @default.
- W4281917085 cites W2810612816 @default.
- W4281917085 cites W2891084688 @default.
- W4281917085 cites W2911408624 @default.
- W4281917085 cites W2915290419 @default.
- W4281917085 cites W2922120784 @default.
- W4281917085 cites W2925918354 @default.
- W4281917085 cites W2947150208 @default.
- W4281917085 cites W2966261467 @default.
- W4281917085 cites W2967918238 @default.
- W4281917085 cites W2976653310 @default.
- W4281917085 cites W2982520686 @default.
- W4281917085 cites W2993460755 @default.
- W4281917085 cites W2994585472 @default.
- W4281917085 cites W3011178559 @default.
- W4281917085 cites W3011622061 @default.
- W4281917085 cites W3016212783 @default.
- W4281917085 cites W3030848819 @default.
- W4281917085 cites W3038995504 @default.
- W4281917085 cites W3040953964 @default.
- W4281917085 cites W3045749034 @default.
- W4281917085 cites W3045899263 @default.
- W4281917085 cites W3089348304 @default.
- W4281917085 cites W3090495455 @default.
- W4281917085 cites W3095587685 @default.
- W4281917085 cites W3099463467 @default.
- W4281917085 cites W3108977719 @default.
- W4281917085 cites W3134051489 @default.
- W4281917085 cites W3139158277 @default.
- W4281917085 cites W3145334405 @default.
- W4281917085 cites W3148757021 @default.
- W4281917085 cites W3151041352 @default.
- W4281917085 cites W3160524864 @default.
- W4281917085 cites W3161772041 @default.
- W4281917085 cites W3162147522 @default.
- W4281917085 cites W3162426834 @default.
- W4281917085 cites W3164700519 @default.
- W4281917085 cites W3166330342 @default.
- W4281917085 cites W3180923305 @default.
- W4281917085 cites W3189265697 @default.
- W4281917085 cites W3202054862 @default.
- W4281917085 cites W4210442342 @default.
- W4281917085 cites W4225141722 @default.
- W4281917085 doi "https://doi.org/10.1002/art.42256" @default.
- W4281917085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35656967" @default.