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• W4281918013 endingPage "114749" @default.
• W4281918013 startingPage "114749" @default.
• W4281918013 abstract "Formaldehyde (FA), as a reactive signaling molecule, plays an important role in living systems through a diverse array of cellular pathways. However, no systematic investigation for detection and imaging of FA by rendering cells transiently permeable has been reported yet. Specifically, we developed a new cell-permeable fluorescence probe functionality that was enhanced cellular entry efficiency and well retained intracellularly after activation for visualizing endogenous FA changes. Moreover, a smart multi-lock system -key-and-lock strategy，which have provoked a starting point for the use of probe and related biochemical tools to monitor FA in lysosomes. The versatile latent fluorophore that can undergo a subsequent self-immolative spacer for interrogating the roles and functions of FA in living systems as well as related biomedical applications." @default.
• W4281918013 created "2022-06-13" @default.
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• W4281918013 date "2022-09-01" @default.
• W4281918013 modified "2023-10-16" @default.
• W4281918013 title "Cell-permeable fluorescent indicator for imaging formaldehyde activity in living systems" @default.
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• W4281918013 doi "https://doi.org/10.1016/j.ab.2022.114749" @default.
• W4281918013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35636460" @default.
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