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- W4281934549 abstract "Background: Many studies conducted in Algeria have found that approximately 39% (Boutebba M et al) to 43% (Sadoun et al) of diabetics use the plants concomitantly with their conventional drugs with 22% describing adverse reactions (hypoglycemia or hyperglycemia).This notion is not taken in consideration by many clinicians due to the lack of information and the absence of trainings in the field of phytotherapy, NHP and their potential interactions with drugs. Aim: Our aim is to help health professional identifying potential herbs-antidiabetic drugs interaction by creating a simple tool by reviewing the literature. Method: Databases (MEDLINE, Google scholar, science direct, NCBI) and books (as Medi-herb, WHO monographs on selected medicinal plants…) were consulted searching for the clinical studies, case reports and studies published in term of herb-antidiabetic drugs interaction. The most commonly used plants by the Algerian diabetics were selected using the previous ethnopharmacological surveys and the antidiabetic effect of these plants to deduct the potential pharmacodynamic interactions were searched. The interactions were classified into four groups each group corresponds to a level of evidence:1.Probable interactions with high chances to produce: include interactions supported by clinical evidence and case studies.2.Possible interactions with medium chances to produce: include interactions based on animal or in vitro data.3.Theoretical interactions: include theoretical interactions extrapolated from pharmacodynamic and pharmacokinetic data.4.No reported interactions or theoretical interactions identified from the literature. Results: Thirty-one plants and six antidiabetic drugs were retained to create the tool. More than 200 references were reviewed. A grid was established with color keys that were used to simplify the detection of the interaction and its level of evidence by the user. Discussion: The tool that we developed can help health professionals who take care of diabetics to determine the risk of hyperglycemia or hypoglycemia and avoiding them which contributes to a better control of glucose level and an improvement of the diabetes management." @default.
- W4281934549 created "2022-06-13" @default.
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- W4281934549 date "2022-04-01" @default.
- W4281934549 modified "2023-09-30" @default.
- W4281934549 title "IDF21-0212 Interactions between herbs and antidiabetic drugs and their effects on glycemia: A simple tool for a fast identification" @default.
- W4281934549 doi "https://doi.org/10.1016/j.diabres.2022.109498" @default.
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