FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281950175> ?p ?o ?g. }

• W4281950175 abstract "Abstract Spinal cord injury (SCI) is a devastating condition for patients, affecting nearly 2.5 million people globally. Multiple side effects of SCI have resulted in a terrible life experience for SCI patients, of which neuropathic pain has attracted the most scientific interest. Even though many efforts have been made to attenuate or eliminate neuropathic pain induced by SCI, the outcomes for patients are still poor. Therefore, identifying novel diagnosis or therapeutic targets of SCI-induced neuropathic pain is urgently needed. Recently, multiple functions of long non-coding RNA (lncRNA) have been elucidated, including those in SCI-induced neuropathic pain. In this study, lncRNA small nucleolar RNA host gene 12 (SNHG12) was found to be upregulated in the dorsal root ganglion (DRGs) of rats with spare nerve injury (SNI). By constructing SCI rat models, we found that lncRNA SNHG12 expression was increased in the DRGs, and mainly distributed in the cytoplasm of PC12 cells. Paw withdrawal threshold (PWT), paw withdrawal latency (PWL), and enzyme linked immunosorbent assay (ELISA) results indicated that lncRNA SNHG12 knockdown attenuated SNI-induced neuropathic pain, and decreased the expression levels of interleukin (IL)−1β, IL-6, and tumour necrosis factor α (TNF-α) in the DRGs. Bioinformatics analysis, RNA pull-down, chromatin immunoprecipitation (ChIP), and luciferase reporter gene assays showed that lncRNA SNHG12 regulates the RAD23 homologue B, nucleotide excision repair protein (RAD23B) expression, through targeting micro RNA (miR)−494-3p. Furthermore, the study indicated that Kruppel-Like Factor 2 (KLF2) could regulate lncRNA SNHG12 expression in PC12 cells. This study identified a novel KLF2/lncRNA SNHG12/miR-494-3p/RAD23B axis in SNI-induced neuropathic pain, which might provide a new insight for developing novel diagnosis, or therapeutic targets of SCI-induced neuropathic pain in the future." @default.
• W4281950175 created "2022-06-13" @default.
• W4281950175 creator A5011869476 @default.
• W4281950175 creator A5028220478 @default.
• W4281950175 creator A5038327626 @default.
• W4281950175 creator A5042608150 @default.
• W4281950175 creator A5066283377 @default.
• W4281950175 creator A5071067099 @default.
• W4281950175 creator A5084084838 @default.
• W4281950175 creator A5084535097 @default.
• W4281950175 date "2022-05-27" @default.
• W4281950175 modified "2023-10-09" @default.
• W4281950175 title "Identifying a novel KLF2/lncRNA SNHG12/miR-494-3p/RAD23B axis in Spare Nerve Injury-induced neuropathic pain" @default.
• W4281950175 cites W1549039080 @default.
• W4281950175 cites W1967295031 @default.
• W4281950175 cites W1975638090 @default.
• W4281950175 cites W1977494370 @default.
• W4281950175 cites W2000426718 @default.
• W4281950175 cites W2023053568 @default.
• W4281950175 cites W2035120744 @default.
• W4281950175 cites W2037702549 @default.
• W4281950175 cites W2086681335 @default.
• W4281950175 cites W2087616533 @default.
• W4281950175 cites W2171096629 @default.
• W4281950175 cites W2528388077 @default.
• W4281950175 cites W2552336026 @default.
• W4281950175 cites W2750434008 @default.
• W4281950175 cites W2784570320 @default.
• W4281950175 cites W2803913659 @default.
• W4281950175 cites W2810758772 @default.
• W4281950175 cites W2900470392 @default.
• W4281950175 cites W2900932032 @default.
• W4281950175 cites W2952176462 @default.
• W4281950175 cites W2974791924 @default.
• W4281950175 cites W2991539675 @default.
• W4281950175 cites W3005166563 @default.
• W4281950175 cites W3006985331 @default.
• W4281950175 cites W3008392335 @default.
• W4281950175 cites W3026644954 @default.
• W4281950175 cites W3027263050 @default.
• W4281950175 cites W3036013915 @default.
• W4281950175 cites W3041394732 @default.
• W4281950175 cites W3048563347 @default.
• W4281950175 cites W3107298263 @default.
• W4281950175 cites W3113078678 @default.
• W4281950175 cites W3114944542 @default.
• W4281950175 doi "https://doi.org/10.1038/s41420-022-01060-y" @default.
• W4281950175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35624111" @default.
• W4281950175 hasPublicationYear "2022" @default.
• W4281950175 type Work @default.
• W4281950175 citedByCount "3" @default.
• W4281950175 countsByYear W42819501752023 @default.
• W4281950175 crossrefType "journal-article" @default.
• W4281950175 hasAuthorship W4281950175A5011869476 @default.
• W4281950175 hasAuthorship W4281950175A5028220478 @default.
• W4281950175 hasAuthorship W4281950175A5038327626 @default.
• W4281950175 hasAuthorship W4281950175A5042608150 @default.
• W4281950175 hasAuthorship W4281950175A5066283377 @default.
• W4281950175 hasAuthorship W4281950175A5071067099 @default.
• W4281950175 hasAuthorship W4281950175A5084084838 @default.
• W4281950175 hasAuthorship W4281950175A5084535097 @default.
• W4281950175 hasBestOaLocation W42819501751 @default.
• W4281950175 hasConcept C101762097 @default.
• W4281950175 hasConcept C104317684 @default.
• W4281950175 hasConcept C118552586 @default.
• W4281950175 hasConcept C134320426 @default.
• W4281950175 hasConcept C150194340 @default.
• W4281950175 hasConcept C173396325 @default.
• W4281950175 hasConcept C2775991916 @default.
• W4281950175 hasConcept C2776281502 @default.
• W4281950175 hasConcept C2777107010 @default.
• W4281950175 hasConcept C2780775167 @default.
• W4281950175 hasConcept C42219234 @default.
• W4281950175 hasConcept C502942594 @default.
• W4281950175 hasConcept C55493867 @default.
• W4281950175 hasConcept C71924100 @default.
• W4281950175 hasConcept C86803240 @default.
• W4281950175 hasConceptScore W4281950175C101762097 @default.
• W4281950175 hasConceptScore W4281950175C104317684 @default.
• W4281950175 hasConceptScore W4281950175C118552586 @default.
• W4281950175 hasConceptScore W4281950175C134320426 @default.
• W4281950175 hasConceptScore W4281950175C150194340 @default.
• W4281950175 hasConceptScore W4281950175C173396325 @default.
• W4281950175 hasConceptScore W4281950175C2775991916 @default.
• W4281950175 hasConceptScore W4281950175C2776281502 @default.
• W4281950175 hasConceptScore W4281950175C2777107010 @default.
• W4281950175 hasConceptScore W4281950175C2780775167 @default.
• W4281950175 hasConceptScore W4281950175C42219234 @default.
• W4281950175 hasConceptScore W4281950175C502942594 @default.
• W4281950175 hasConceptScore W4281950175C55493867 @default.
• W4281950175 hasConceptScore W4281950175C71924100 @default.
• W4281950175 hasConceptScore W4281950175C86803240 @default.
• W4281950175 hasIssue "1" @default.
• W4281950175 hasLocation W42819501751 @default.
• W4281950175 hasLocation W42819501752 @default.
• W4281950175 hasLocation W42819501753 @default.
• W4281950175 hasOpenAccess W4281950175 @default.
• W4281950175 hasPrimaryLocation W42819501751 @default.
• W4281950175 hasRelatedWork W1964977946 @default.
• W4281950175 hasRelatedWork W2008800555 @default.

• next