Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281953373> ?p ?o ?g. }
- W4281953373 endingPage "1093" @default.
- W4281953373 startingPage "1093" @default.
- W4281953373 abstract "Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. The aim of this study is to investigate the protective effects and the underlying mechanisms of vanadium(IV)-chlorodipicolinate ([VIVO(dipic-Cl)(H2O)2, VOdipic-Cl]) in a mouse model of NAFLD induced by a high-fat diet (HFD). VOdipic-Cl (10 mg/kg/day body weight) treatment for 4 weeks significantly controlled body weight gain, and effectively reduced the increase in serum and hepatic triglyceride (TG) and total cholesterol (TC) levels, mitigated pathological injury, decreased malondialdehyde (MDA) level, and inhibited endoplasmic reticulum (ER) stress and inflammatory response in the livers of C57BL/6 obese mice. Moreover, RNA-sequencing analysis revealed distinct transcriptional profiles with differentially expressed genes (DEGs) in livers. We found that VOdipic-Cl effectively down-regulated genes related to lipid synthesis and up-regulated genes related to fatty acid transport and lipolysis, and down-regulated the expression of genes related to ER stress and immune response in the livers of obese mice. In conclusion, VOdipic-Cl effectively prevented hepatic steatosis by controlling body weight, mitigating oxidative stress, and regulating the expression of genes related to lipid metabolism, ER stress and immune response, which provides new insights into the molecular mechanism of the protective effect of VOdipic-Cl against hepatic steatosis." @default.
- W4281953373 created "2022-06-13" @default.
- W4281953373 creator A5026621683 @default.
- W4281953373 creator A5036038808 @default.
- W4281953373 creator A5050914571 @default.
- W4281953373 creator A5072056125 @default.
- W4281953373 creator A5075556241 @default.
- W4281953373 creator A5080154616 @default.
- W4281953373 creator A5082199637 @default.
- W4281953373 creator A5084130934 @default.
- W4281953373 creator A5085766801 @default.
- W4281953373 creator A5087696204 @default.
- W4281953373 date "2022-05-31" @default.
- W4281953373 modified "2023-09-25" @default.
- W4281953373 title "Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation" @default.
- W4281953373 cites W1824231381 @default.
- W4281953373 cites W1978921042 @default.
- W4281953373 cites W1985592156 @default.
- W4281953373 cites W1998416388 @default.
- W4281953373 cites W2007078899 @default.
- W4281953373 cites W2014025452 @default.
- W4281953373 cites W2027250675 @default.
- W4281953373 cites W2037705731 @default.
- W4281953373 cites W2044052768 @default.
- W4281953373 cites W2059461113 @default.
- W4281953373 cites W2061662539 @default.
- W4281953373 cites W2064759630 @default.
- W4281953373 cites W2066069709 @default.
- W4281953373 cites W2066453798 @default.
- W4281953373 cites W2068353681 @default.
- W4281953373 cites W2072059059 @default.
- W4281953373 cites W2073804093 @default.
- W4281953373 cites W2080094617 @default.
- W4281953373 cites W2085171399 @default.
- W4281953373 cites W2102278945 @default.
- W4281953373 cites W2106693109 @default.
- W4281953373 cites W2110079579 @default.
- W4281953373 cites W2119034410 @default.
- W4281953373 cites W2123429977 @default.
- W4281953373 cites W2128057304 @default.
- W4281953373 cites W2131290128 @default.
- W4281953373 cites W2134814870 @default.
- W4281953373 cites W2154431984 @default.
- W4281953373 cites W2159298950 @default.
- W4281953373 cites W2162943945 @default.
- W4281953373 cites W2170551349 @default.
- W4281953373 cites W2170714239 @default.
- W4281953373 cites W2183553053 @default.
- W4281953373 cites W2298753429 @default.
- W4281953373 cites W2301830968 @default.
- W4281953373 cites W2302819577 @default.
- W4281953373 cites W2321179708 @default.
- W4281953373 cites W2415778146 @default.
- W4281953373 cites W2417739134 @default.
- W4281953373 cites W2467342549 @default.
- W4281953373 cites W2513893629 @default.
- W4281953373 cites W2582192919 @default.
- W4281953373 cites W2598155126 @default.
- W4281953373 cites W2615637571 @default.
- W4281953373 cites W2734724639 @default.
- W4281953373 cites W2752428556 @default.
- W4281953373 cites W2759997926 @default.
- W4281953373 cites W2768061433 @default.
- W4281953373 cites W2770129291 @default.
- W4281953373 cites W2785779482 @default.
- W4281953373 cites W2788261792 @default.
- W4281953373 cites W2789865714 @default.
- W4281953373 cites W2793319062 @default.
- W4281953373 cites W2806282630 @default.
- W4281953373 cites W2810166530 @default.
- W4281953373 cites W2810423511 @default.
- W4281953373 cites W2966732861 @default.
- W4281953373 cites W2967638167 @default.
- W4281953373 cites W2977274448 @default.
- W4281953373 cites W2981086540 @default.
- W4281953373 cites W2998296493 @default.
- W4281953373 cites W3009220429 @default.
- W4281953373 cites W3013645635 @default.
- W4281953373 cites W3118589865 @default.
- W4281953373 cites W3182030891 @default.
- W4281953373 cites W3208161049 @default.
- W4281953373 cites W3212824212 @default.
- W4281953373 cites W4213033709 @default.
- W4281953373 doi "https://doi.org/10.3390/antiox11061093" @default.
- W4281953373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35739990" @default.
- W4281953373 hasPublicationYear "2022" @default.
- W4281953373 type Work @default.
- W4281953373 citedByCount "1" @default.
- W4281953373 countsByYear W42819533732023 @default.
- W4281953373 crossrefType "journal-article" @default.
- W4281953373 hasAuthorship W4281953373A5026621683 @default.
- W4281953373 hasAuthorship W4281953373A5036038808 @default.
- W4281953373 hasAuthorship W4281953373A5050914571 @default.
- W4281953373 hasAuthorship W4281953373A5072056125 @default.
- W4281953373 hasAuthorship W4281953373A5075556241 @default.
- W4281953373 hasAuthorship W4281953373A5080154616 @default.
- W4281953373 hasAuthorship W4281953373A5082199637 @default.
- W4281953373 hasAuthorship W4281953373A5084130934 @default.