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• W4281961566 abstract "Point-of-care detection of viral infection is required for effective contact-tracing, epidemiological surveillance, and linkage to care. Traditional diagnostic platforms relying on either antigen detection or nucleic amplification are limited by sensitivity and the need for costly laboratory infrastructure, respectively. Recently, CRISPR-based diagnostics have emerged as an alternative, combining equipment light workflows with high specificity and sensitivity. However, as a nascent technology, several outstanding challenges to widespread field deployment remain. These include the need for pre-detection amplification of target molecules, the lack of standardization in sample preparation and reagent composition, and only equivocal assessments of the unit-economics relative to traditional antigen or polymerase chain reaction-based diagnostics. This review summarizes recent advances with the potential to overcome existing translational barriers, describes the events in CRISPR-based detection of target molecules, and offers perspective on how multiple approaches can be combined to decrease the limit of detection without introducing pre-amplification." @default.
• W4281961566 created "2022-06-13" @default.
• W4281961566 creator A5026950089 @default.
• W4281961566 date "2022-06-01" @default.
• W4281961566 modified "2023-09-25" @default.
• W4281961566 title "CRISPR-Based Diagnostics for Point-of-Care Viral Detection" @default.
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• W4281961566 doi "https://doi.org/10.3390/ijtm2020017" @default.
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