Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281961571> ?p ?o ?g. }
- W4281961571 endingPage "403" @default.
- W4281961571 startingPage "390" @default.
- W4281961571 abstract "Herein, we report the development of a drug delivery system (DDS) that can be very efficiently targeted to a breast cancer site by both aptamer and external magnetic field to achieve chemo-photothermal-starvation combination effects. Cancer starvation agent glucose oxidase was chemically attached to synthesized iron oxide nanoparticles (NPs) which were entrapped inside PLGA polymer along with Doxorubicin. To achieve photothermal property, the surface of the developed DDS was coated with polydopamine (PDA) to which aptamer was conjugated so that the DDS can be targeted by both external magnet and aptamer. The final size of the aptamer decorated DDS was 185.2 ± 3 nm. Upon NIR (near-infrared) laser irradiation, the DDS can raise the suspension's temperature over 50 °C within 10 min. Accelerated drug release was achieved in acidic conditions (pH 5.5) in the presence of laser irradiation due to both pH sensitivity and photothermal effect. Efficient dual targeting along with laser irradiation could reduce in vitro viability of MDA-MB-231 cells to 9.1 ± 2.3% resulting in a synergistic effect, whereas the same group could inhibit 90.6 ± 2.7% tumor growth showing the best therapeutic effect in a mouse model. The obtained results suggest that the developed DDS is an effective tool to treat various cancers by combination therapy." @default.
- W4281961571 created "2022-06-13" @default.
- W4281961571 creator A5006025102 @default.
- W4281961571 creator A5042183474 @default.
- W4281961571 creator A5042913687 @default.
- W4281961571 creator A5055646108 @default.
- W4281961571 creator A5070741329 @default.
- W4281961571 creator A5074805557 @default.
- W4281961571 date "2022-01-01" @default.
- W4281961571 modified "2023-09-30" @default.
- W4281961571 title "Systemic Co-delivery of drugs by a pH- and photosensitive smart nanocarrier to treat cancer by chemo-photothermal-starvation combination therapy" @default.
- W4281961571 cites W1974381813 @default.
- W4281961571 cites W2000348243 @default.
- W4281961571 cites W2021826570 @default.
- W4281961571 cites W2024793632 @default.
- W4281961571 cites W2028252077 @default.
- W4281961571 cites W2034913332 @default.
- W4281961571 cites W2045080998 @default.
- W4281961571 cites W2056292486 @default.
- W4281961571 cites W2069991543 @default.
- W4281961571 cites W2082262145 @default.
- W4281961571 cites W2115578751 @default.
- W4281961571 cites W2151602522 @default.
- W4281961571 cites W2335405043 @default.
- W4281961571 cites W2335924114 @default.
- W4281961571 cites W2361791156 @default.
- W4281961571 cites W2485351038 @default.
- W4281961571 cites W2494447917 @default.
- W4281961571 cites W2547655849 @default.
- W4281961571 cites W2588453634 @default.
- W4281961571 cites W2597613988 @default.
- W4281961571 cites W2617797208 @default.
- W4281961571 cites W2767334197 @default.
- W4281961571 cites W2788610544 @default.
- W4281961571 cites W2802686151 @default.
- W4281961571 cites W2803031642 @default.
- W4281961571 cites W2805521463 @default.
- W4281961571 cites W2885350532 @default.
- W4281961571 cites W2912993657 @default.
- W4281961571 cites W2967010203 @default.
- W4281961571 cites W2967356649 @default.
- W4281961571 cites W2974996748 @default.
- W4281961571 cites W2993381695 @default.
- W4281961571 cites W3004619097 @default.
- W4281961571 cites W3007969679 @default.
- W4281961571 cites W3028101403 @default.
- W4281961571 cites W3041413521 @default.
- W4281961571 cites W3094528758 @default.
- W4281961571 cites W3094566169 @default.
- W4281961571 cites W3100370737 @default.
- W4281961571 cites W3110996270 @default.
- W4281961571 cites W3115277200 @default.
- W4281961571 cites W3128646645 @default.
- W4281961571 cites W3138525339 @default.
- W4281961571 cites W3157048626 @default.
- W4281961571 cites W3169583693 @default.
- W4281961571 cites W3182880719 @default.
- W4281961571 cites W3201575333 @default.
- W4281961571 cites W4200169925 @default.
- W4281961571 cites W4200548061 @default.
- W4281961571 cites W4207084410 @default.
- W4281961571 doi "https://doi.org/10.1016/j.smaim.2022.05.003" @default.
- W4281961571 hasPublicationYear "2022" @default.
- W4281961571 type Work @default.
- W4281961571 citedByCount "8" @default.
- W4281961571 countsByYear W42819615712022 @default.
- W4281961571 countsByYear W42819615712023 @default.
- W4281961571 crossrefType "journal-article" @default.
- W4281961571 hasAuthorship W4281961571A5006025102 @default.
- W4281961571 hasAuthorship W4281961571A5042183474 @default.
- W4281961571 hasAuthorship W4281961571A5042913687 @default.
- W4281961571 hasAuthorship W4281961571A5055646108 @default.
- W4281961571 hasAuthorship W4281961571A5070741329 @default.
- W4281961571 hasAuthorship W4281961571A5074805557 @default.
- W4281961571 hasBestOaLocation W42819615711 @default.
- W4281961571 hasConcept C111337013 @default.
- W4281961571 hasConcept C112613896 @default.
- W4281961571 hasConcept C121332964 @default.
- W4281961571 hasConcept C121608353 @default.
- W4281961571 hasConcept C12554922 @default.
- W4281961571 hasConcept C126322002 @default.
- W4281961571 hasConcept C128972844 @default.
- W4281961571 hasConcept C141071460 @default.
- W4281961571 hasConcept C153911025 @default.
- W4281961571 hasConcept C171250308 @default.
- W4281961571 hasConcept C178790620 @default.
- W4281961571 hasConcept C18150654 @default.
- W4281961571 hasConcept C182606246 @default.
- W4281961571 hasConcept C185544564 @default.
- W4281961571 hasConcept C185592680 @default.
- W4281961571 hasConcept C192562407 @default.
- W4281961571 hasConcept C21951064 @default.
- W4281961571 hasConcept C2776694085 @default.
- W4281961571 hasConcept C2777742735 @default.
- W4281961571 hasConcept C2779820397 @default.
- W4281961571 hasConcept C2781303535 @default.
- W4281961571 hasConcept C521977710 @default.
- W4281961571 hasConcept C71924100 @default.