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- W4281973742 abstract "Long non-coding RNAs (lncRNAs) are a category of non-coding RNAs (ncRNAs) that are more than 200 bases long and play major regulatory roles in a wide range of biologic processes, including hematopoeisis and metabolism. Metabolism in cells is an immensely complex process that involves the interconnection and unification of numerous signaling pathways. A growing body of affirmation marks that lncRNAs do participate in metabolism, both directly and indirectly, via metabolic regulation of enzymes and signaling pathways, respectively. The complexities are disclosed by the latest studies demonstrating how lncRNAs could indeed alter tissue-specific metabolism. We have entered a new realm for discovery that is both intimidating and intriguing. Understanding the different functions of lncRNAs in various cellular pathways aids in the advancement of predictive and therapeutic capabilities for a wide variety of myelodysplastic and metabolic disorders. This review has tried to give an overview of the different ncRNAs and their effects on hematopoiesis and metabolism. We have focused on the pathway of action of several lncRNAs and have also delved into their prognostic value. Their use as biomarkers and possible therapeutic targets has also been discussed. SIGNIFICANCE STATEMENT: This review has tried to give an overview of the different ncRNAs and their effects on hematopoiesis and metabolism. The pathway of action of several lncRNAs and their prognostic value was discussed. Their use as biomarkers and possible therapeutic targets has also been elaborated." @default.
- W4281973742 created "2022-06-13" @default.
- W4281973742 creator A5030393984 @default.
- W4281973742 creator A5039229702 @default.
- W4281973742 creator A5042974501 @default.
- W4281973742 creator A5058903873 @default.
- W4281973742 date "2022-06-06" @default.
- W4281973742 modified "2023-09-29" @default.
- W4281973742 title "Long Non-Coding RNAs as Cellular Metabolism and Haematopoiesis Regulators" @default.
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- W4281973742 doi "https://doi.org/10.1124/jpet.121.001120" @default.
- W4281973742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35667690" @default.
- W4281973742 hasPublicationYear "2022" @default.
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