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- W4281987788 abstract "The work deals with the design, synthesis and biological activity of new carbamate cholinesterase inhibitors. It is focused on selected syntheses of new carbamate derivatives, which were tested for their anticholinesterase activity against acetylcholinesterase as well as butyrylcholinesterase. Despite various theories in the pathogenesis of Alzheimer's disease, drugs that can inhibit these two enzymes still represent the major approach to the treatment of this neurodegenerative disease. Many of the newly synthesized compounds have unique chemical structure. Recently, the approach to the synthesis of new cholinesterase inhibitors has focused on the preparation of potential drugs, containing in their chemical structure fragments of already known drugs, commonly used in the pharmacotherapy of Alzheimer's disease, but also other diseases. The aim of preparing these compounds is to affect several biological systems simultaneously. These multipotent compounds have been termed multi-target-directed ligands; the molecules of drugs used to treat Alzheimer's disease always contain a pharmacophore acting as a cholinesterase inhibitor, which represents the mainstay of therapy." @default.
- W4281987788 created "2022-06-13" @default.
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- W4281987788 date "2022-06-10" @default.
- W4281987788 modified "2023-10-17" @default.
- W4281987788 title "Design, Synthesis and Biological Activity of New Carbamate Cholinesterase Inhibitors" @default.
- W4281987788 doi "https://doi.org/10.54779/chl20220372" @default.
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