Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281992017> ?p ?o ?g. }
- W4281992017 abstract "Renal fibrosis is a pathological characteristic of the endpoint of chronic kidney disease (CKD), which remains a major public health problem. None of the current therapies is effective in stopping kidney fibrosis progression. In light of our novel detection of a potential antifibrosis of microcystins (MCs), we investigate the renoprotection effect of MCs with UUO-induced renal fibrosis. The treatment of MCs was initiated in model animals in advance of UUO operation. After determining that the antifibrotic effect of MCs was independent of its toxicity, our study focused on the renoprotection of microcystin-RR (MC-RR), a lower toxic congener of MCs, in UUO mice and the cell models in vitro . The co-immunoprecipitation assay and recombination plasmid transfection were used in the investigation of the mechanism of antifibrosis of MC-RR . The data show that MC-RR substantially exerts an effect on renoprotection with suppression of the expression of TGF-β1/Smad signaling molecules and a blockage in epithelial dedifferentiation and myofibroblast activation in UUO model animals. MC-RR shows a binding directly to pyruvate kinase M2 (PKM2), downregulates PKM2-HIF-1α signaling, restores the inhibited expression of MMP-7 and MMP-13, and reduces the upregulated expression of MMP-9 in UUO renal tissues. The current study demonstrates a novel effect of MC-RR on renoprotection in kidney damage, which could be conducted in therapeutics for chronic kidney disease." @default.
- W4281992017 created "2022-06-13" @default.
- W4281992017 creator A5000195058 @default.
- W4281992017 creator A5001070941 @default.
- W4281992017 creator A5031192469 @default.
- W4281992017 creator A5036278940 @default.
- W4281992017 creator A5047070262 @default.
- W4281992017 creator A5061195656 @default.
- W4281992017 creator A5070372452 @default.
- W4281992017 creator A5075877965 @default.
- W4281992017 creator A5086161254 @default.
- W4281992017 date "2022-06-09" @default.
- W4281992017 modified "2023-10-01" @default.
- W4281992017 title "Renoprotection of Microcystin-RR in Unilateral Ureteral Obstruction-Induced Renal Fibrosis: Targeting the PKM2-HIF-1α Pathway" @default.
- W4281992017 cites W1676246072 @default.
- W4281992017 cites W1783939843 @default.
- W4281992017 cites W1793883704 @default.
- W4281992017 cites W1969284445 @default.
- W4281992017 cites W1970967215 @default.
- W4281992017 cites W1975215468 @default.
- W4281992017 cites W1998366361 @default.
- W4281992017 cites W2009164922 @default.
- W4281992017 cites W2026027152 @default.
- W4281992017 cites W2027936250 @default.
- W4281992017 cites W2034198619 @default.
- W4281992017 cites W2053470746 @default.
- W4281992017 cites W2078657995 @default.
- W4281992017 cites W2125836344 @default.
- W4281992017 cites W2152850030 @default.
- W4281992017 cites W2153586956 @default.
- W4281992017 cites W2162102103 @default.
- W4281992017 cites W2169474553 @default.
- W4281992017 cites W2187985754 @default.
- W4281992017 cites W2214850664 @default.
- W4281992017 cites W2281110192 @default.
- W4281992017 cites W2405183840 @default.
- W4281992017 cites W2553644640 @default.
- W4281992017 cites W2576066242 @default.
- W4281992017 cites W2577734878 @default.
- W4281992017 cites W2591251590 @default.
- W4281992017 cites W2607704951 @default.
- W4281992017 cites W2613674801 @default.
- W4281992017 cites W2621172390 @default.
- W4281992017 cites W2883225378 @default.
- W4281992017 cites W2913590717 @default.
- W4281992017 cites W2916525943 @default.
- W4281992017 cites W2940438627 @default.
- W4281992017 cites W2945382930 @default.
- W4281992017 cites W2947624257 @default.
- W4281992017 cites W2960173085 @default.
- W4281992017 cites W2963976604 @default.
- W4281992017 cites W2985676661 @default.
- W4281992017 cites W3006609143 @default.
- W4281992017 cites W3007511370 @default.
- W4281992017 cites W3037026836 @default.
- W4281992017 cites W3037663384 @default.
- W4281992017 cites W3170620462 @default.
- W4281992017 cites W4211210745 @default.
- W4281992017 cites W4229508150 @default.
- W4281992017 doi "https://doi.org/10.3389/fphar.2022.830312" @default.
- W4281992017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35754468" @default.
- W4281992017 hasPublicationYear "2022" @default.
- W4281992017 type Work @default.
- W4281992017 citedByCount "2" @default.
- W4281992017 countsByYear W42819920172023 @default.
- W4281992017 crossrefType "journal-article" @default.
- W4281992017 hasAuthorship W4281992017A5000195058 @default.
- W4281992017 hasAuthorship W4281992017A5001070941 @default.
- W4281992017 hasAuthorship W4281992017A5031192469 @default.
- W4281992017 hasAuthorship W4281992017A5036278940 @default.
- W4281992017 hasAuthorship W4281992017A5047070262 @default.
- W4281992017 hasAuthorship W4281992017A5061195656 @default.
- W4281992017 hasAuthorship W4281992017A5070372452 @default.
- W4281992017 hasAuthorship W4281992017A5075877965 @default.
- W4281992017 hasAuthorship W4281992017A5086161254 @default.
- W4281992017 hasBestOaLocation W42819920171 @default.
- W4281992017 hasConcept C126322002 @default.
- W4281992017 hasConcept C185592680 @default.
- W4281992017 hasConcept C2778653478 @default.
- W4281992017 hasConcept C2780091579 @default.
- W4281992017 hasConcept C2780559512 @default.
- W4281992017 hasConcept C502942594 @default.
- W4281992017 hasConcept C71924100 @default.
- W4281992017 hasConcept C98274493 @default.
- W4281992017 hasConceptScore W4281992017C126322002 @default.
- W4281992017 hasConceptScore W4281992017C185592680 @default.
- W4281992017 hasConceptScore W4281992017C2778653478 @default.
- W4281992017 hasConceptScore W4281992017C2780091579 @default.
- W4281992017 hasConceptScore W4281992017C2780559512 @default.
- W4281992017 hasConceptScore W4281992017C502942594 @default.
- W4281992017 hasConceptScore W4281992017C71924100 @default.
- W4281992017 hasConceptScore W4281992017C98274493 @default.
- W4281992017 hasFunder F4320321001 @default.
- W4281992017 hasLocation W42819920171 @default.
- W4281992017 hasLocation W42819920172 @default.
- W4281992017 hasLocation W42819920173 @default.
- W4281992017 hasOpenAccess W4281992017 @default.
- W4281992017 hasPrimaryLocation W42819920171 @default.
- W4281992017 hasRelatedWork W2412727020 @default.
- W4281992017 hasRelatedWork W2748952813 @default.