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- W4281994635 abstract "Bacteriophytochromes (BphPs) are photoreceptors that regulate a wide range of biological mechanisms via red light–absorbing (Pr)–to–far-red light–absorbing (Pfr) reversible photoconversion. The structural dynamics underlying Pfr-to-Pr photoconversion in a liquid solution phase are not well understood. We used time-resolved x-ray solution scattering (TRXSS) to capture light-induced structural transitions in the bathy BphP photosensory module of Pseudomonas aeruginosa . Kinetic analysis of the TRXSS data identifies three distinct structural species, which are attributed to lumi-F, meta-F, and Pr, connected by time constants of 95 μs and 21 ms. Structural analysis based on molecular dynamics simulations shows that the light activation of PaBphP accompanies quaternary structural rearrangements from an “II”-framed close form of the Pfr state to an “O”-framed open form of the Pr state in terms of the helical backbones. This study provides mechanistic insights into how modular signaling proteins such as BphPs transmit structural signals over long distances and regulate their downstream biological responses." @default.
- W4281994635 created "2022-06-13" @default.
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- W4281994635 date "2022-05-27" @default.
- W4281994635 modified "2023-10-14" @default.
- W4281994635 title "Light-induced protein structural dynamics in bacteriophytochrome revealed by time-resolved x-ray solution scattering" @default.
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- W4281994635 doi "https://doi.org/10.1126/sciadv.abm6278" @default.
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