Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281999097> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4281999097 abstract "The Benzo(a)pyrene (Bap) exposure induced oxidative damage, DNA damage and autophagy. To explore the molecular mechanism of BaP-induced autophagy. In these studies, we first found that heat shock protein 90 (HSP90), heat shock cognate 70 (HSC70) and lysosomal-associated membrane protein type 2 receptor (Lamp-2a) expressions of C57BL mice lung tissue and A549 cells exposed to BaP were significant increase, as well as Bap induced DNA double-strand breaks (DSBs) and activated DNA damage responses, as evidenced by comet assay and α-H2AX foci analysis in A549 cells. Our results demonstrated BaP induced CMA and caused DNA damage. Next, we knocked down HSP90 expression by the HSP90 Inhibitor, NVP-AUY 922, exposed or HSP90α shRNA lentivirus transduction in A549 cells. HSC70 and Lamp-2a expressions of these cells exposed to BaP were not significant increase, which showed that BaP inducted CMA was mediated by HSP90. Further, HSP90α shRNA prevented BaP induced of Bap which suggested BaP regulated CMA and caused DNA damage by HSP90. Our results elucidated a new mechanism of BaP regulated CMA through HSP90." @default.
- W4281999097 created "2022-06-13" @default.
- W4281999097 creator A5011481237 @default.
- W4281999097 creator A5013034476 @default.
- W4281999097 creator A5016549638 @default.
- W4281999097 creator A5027835055 @default.
- W4281999097 creator A5050057456 @default.
- W4281999097 creator A5057762106 @default.
- W4281999097 creator A5061855747 @default.
- W4281999097 creator A5062946064 @default.
- W4281999097 creator A5079821576 @default.
- W4281999097 creator A5090001339 @default.
- W4281999097 date "2022-06-08" @default.
- W4281999097 modified "2023-10-16" @default.
- W4281999097 title "Benzo(a)pyrene regulates chaperone-mediated autophagy via heat shock protein 90" @default.
- W4281999097 doi "https://doi.org/10.1101/2022.06.08.495280" @default.
- W4281999097 hasPublicationYear "2022" @default.
- W4281999097 type Work @default.
- W4281999097 citedByCount "0" @default.
- W4281999097 crossrefType "posted-content" @default.
- W4281999097 hasAuthorship W4281999097A5011481237 @default.
- W4281999097 hasAuthorship W4281999097A5013034476 @default.
- W4281999097 hasAuthorship W4281999097A5016549638 @default.
- W4281999097 hasAuthorship W4281999097A5027835055 @default.
- W4281999097 hasAuthorship W4281999097A5050057456 @default.
- W4281999097 hasAuthorship W4281999097A5057762106 @default.
- W4281999097 hasAuthorship W4281999097A5061855747 @default.
- W4281999097 hasAuthorship W4281999097A5062946064 @default.
- W4281999097 hasAuthorship W4281999097A5079821576 @default.
- W4281999097 hasAuthorship W4281999097A5090001339 @default.
- W4281999097 hasBestOaLocation W42819990971 @default.
- W4281999097 hasConcept C104317684 @default.
- W4281999097 hasConcept C114246631 @default.
- W4281999097 hasConcept C143425029 @default.
- W4281999097 hasConcept C1491633281 @default.
- W4281999097 hasConcept C153911025 @default.
- W4281999097 hasConcept C173396325 @default.
- W4281999097 hasConcept C185592680 @default.
- W4281999097 hasConcept C190232843 @default.
- W4281999097 hasConcept C190283241 @default.
- W4281999097 hasConcept C203522944 @default.
- W4281999097 hasConcept C205260736 @default.
- W4281999097 hasConcept C2775932338 @default.
- W4281999097 hasConcept C2777538855 @default.
- W4281999097 hasConcept C2777560012 @default.
- W4281999097 hasConcept C2780358455 @default.
- W4281999097 hasConcept C552990157 @default.
- W4281999097 hasConcept C55493867 @default.
- W4281999097 hasConcept C81729549 @default.
- W4281999097 hasConcept C86803240 @default.
- W4281999097 hasConcept C95444343 @default.
- W4281999097 hasConceptScore W4281999097C104317684 @default.
- W4281999097 hasConceptScore W4281999097C114246631 @default.
- W4281999097 hasConceptScore W4281999097C143425029 @default.
- W4281999097 hasConceptScore W4281999097C1491633281 @default.
- W4281999097 hasConceptScore W4281999097C153911025 @default.
- W4281999097 hasConceptScore W4281999097C173396325 @default.
- W4281999097 hasConceptScore W4281999097C185592680 @default.
- W4281999097 hasConceptScore W4281999097C190232843 @default.
- W4281999097 hasConceptScore W4281999097C190283241 @default.
- W4281999097 hasConceptScore W4281999097C203522944 @default.
- W4281999097 hasConceptScore W4281999097C205260736 @default.
- W4281999097 hasConceptScore W4281999097C2775932338 @default.
- W4281999097 hasConceptScore W4281999097C2777538855 @default.
- W4281999097 hasConceptScore W4281999097C2777560012 @default.
- W4281999097 hasConceptScore W4281999097C2780358455 @default.
- W4281999097 hasConceptScore W4281999097C552990157 @default.
- W4281999097 hasConceptScore W4281999097C55493867 @default.
- W4281999097 hasConceptScore W4281999097C81729549 @default.
- W4281999097 hasConceptScore W4281999097C86803240 @default.
- W4281999097 hasConceptScore W4281999097C95444343 @default.
- W4281999097 hasLocation W42819990971 @default.
- W4281999097 hasOpenAccess W4281999097 @default.
- W4281999097 hasPrimaryLocation W42819990971 @default.
- W4281999097 hasRelatedWork W1545295100 @default.
- W4281999097 hasRelatedWork W2020918071 @default.
- W4281999097 hasRelatedWork W2048668585 @default.
- W4281999097 hasRelatedWork W2269667475 @default.
- W4281999097 hasRelatedWork W2352035904 @default.
- W4281999097 hasRelatedWork W2789412783 @default.
- W4281999097 hasRelatedWork W2936714466 @default.
- W4281999097 hasRelatedWork W3137596005 @default.
- W4281999097 hasRelatedWork W3201485717 @default.
- W4281999097 hasRelatedWork W4281999097 @default.
- W4281999097 isParatext "false" @default.
- W4281999097 isRetracted "false" @default.
- W4281999097 workType "article" @default.