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• W4282000516 abstract "Gestational diabetes (GDM) is characterized by a glucose tolerance disorder. This may first appear during pregnancy or pre-exist before conception as a form of prediabetes, but there are few data on the pathogenesis of the latter subtype. Female New Zealand obese (NZO) mice serve as a model for this subpopulation of GDM. It was recently shown that GDM is associated with elevated urinary serotonin (5-hydroxytryptamine, 5-HT) levels, but the role of the biogenic amine in subpopulations with prediabetes remains unclear. 5-HT is synthesized in different tissues, including the islets of Langerhans during pregnancy. Furthermore, 5-HT receptors (HTRs) are expressed in tissues important for the regulation of glucose homeostasis, such as liver and pancreas. Interestingly, NZO mice showed elevated plasma and islet 5-HT concentrations as well as impaired glucose-stimulated 5-HT secretion. Incubation of isolated primary NZO islets with 5-HT revealed an inhibitory effect on insulin and glucagon secretion. In primary NZO hepatocytes, 5-HT aggravated hepatic glucose production (HGP), decreased glucose uptake (HGU), glycogen content, and modulated AKT activation as well as cyclic adenosine monophosphate (cAMP) increase, indicating 5-HT downstream modulation. Treatment with an HTR2B antagonist reduced this 5-HT-mediated deterioration of the metabolic state. With its strong effect on glucose metabolism, these data indicate that 5-HT is already a potential indicator of GDM before conception in mice." @default.
• W4282000516 created "2022-06-13" @default.
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• W4282000516 date "2022-06-09" @default.
• W4282000516 modified "2023-10-16" @default.
• W4282000516 title "Role of Serotonin (5-HT) in GDM Prediction Considering Islet and Liver Interplay in Prediabetic Mice during Gestation" @default.
• W4282000516 cites W133548050 @default.
• W4282000516 cites W1920128393 @default.
• W4282000516 cites W1932150911 @default.
• W4282000516 cites W1933608698 @default.
• W4282000516 cites W1980855968 @default.
• W4282000516 cites W1985178609 @default.
• W4282000516 cites W1986455197 @default.
• W4282000516 cites W1989034753 @default.
• W4282000516 cites W1992060970 @default.
• W4282000516 cites W1992395370 @default.
• W4282000516 cites W1997349856 @default.
• W4282000516 cites W1998807018 @default.
• W4282000516 cites W2000232109 @default.
• W4282000516 cites W2000435786 @default.
• W4282000516 cites W2004728383 @default.
• W4282000516 cites W2007486557 @default.
• W4282000516 cites W2013448178 @default.
• W4282000516 cites W2023585901 @default.
• W4282000516 cites W2025060530 @default.
• W4282000516 cites W2027103782 @default.
• W4282000516 cites W2035940741 @default.
• W4282000516 cites W2038146571 @default.
• W4282000516 cites W2051567027 @default.
• W4282000516 cites W2051569791 @default.
• W4282000516 cites W2053073281 @default.
• W4282000516 cites W2065127510 @default.
• W4282000516 cites W2069159433 @default.
• W4282000516 cites W2073078178 @default.
• W4282000516 cites W2075797058 @default.
• W4282000516 cites W2079182908 @default.
• W4282000516 cites W2079577144 @default.
• W4282000516 cites W2081622555 @default.
• W4282000516 cites W2086213189 @default.
• W4282000516 cites W2092288031 @default.
• W4282000516 cites W2092465977 @default.
• W4282000516 cites W2094961834 @default.
• W4282000516 cites W2095482123 @default.
• W4282000516 cites W2098331502 @default.
• W4282000516 cites W2103829969 @default.
• W4282000516 cites W2106183995 @default.
• W4282000516 cites W2108400677 @default.
• W4282000516 cites W2114627400 @default.
• W4282000516 cites W2115778589 @default.
• W4282000516 cites W2119355630 @default.
• W4282000516 cites W2132910924 @default.
• W4282000516 cites W2134948484 @default.
• W4282000516 cites W2135190897 @default.
• W4282000516 cites W2135799781 @default.
• W4282000516 cites W2138071306 @default.
• W4282000516 cites W2141228342 @default.
• W4282000516 cites W2145665725 @default.
• W4282000516 cites W2148049649 @default.
• W4282000516 cites W2148785089 @default.
• W4282000516 cites W2157134448 @default.
• W4282000516 cites W2159445989 @default.
• W4282000516 cites W2161395021 @default.
• W4282000516 cites W2163598333 @default.
• W4282000516 cites W2168932510 @default.
• W4282000516 cites W2171799186 @default.
• W4282000516 cites W223176005 @default.
• W4282000516 cites W2294268013 @default.
• W4282000516 cites W2342695671 @default.
• W4282000516 cites W2381456803 @default.
• W4282000516 cites W240175869 @default.
• W4282000516 cites W2563394258 @default.
• W4282000516 cites W2580159006 @default.
• W4282000516 cites W2590793540 @default.
• W4282000516 cites W2600119935 @default.
• W4282000516 cites W2612575461 @default.
• W4282000516 cites W2776236834 @default.
• W4282000516 cites W2782427223 @default.
• W4282000516 cites W2790248748 @default.
• W4282000516 cites W2886865853 @default.
• W4282000516 cites W2901753855 @default.
• W4282000516 cites W3011907612 @default.
• W4282000516 cites W3021710348 @default.
• W4282000516 cites W30828859 @default.
• W4282000516 cites W3093480251 @default.
• W4282000516 cites W3146723852 @default.
• W4282000516 cites W414797555 @default.
• W4282000516 cites W4200411633 @default.
• W4282000516 cites W4200454061 @default.
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• W4282000516 doi "https://doi.org/10.3390/ijms23126434" @default.
• W4282000516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35742878" @default.
• W4282000516 hasPublicationYear "2022" @default.
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