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- W4282002928 abstract "Abstract The detrimental effects of high-level mercury exposure on the central nervous system as well as effects of low-level exposure during early development have been established. However, no previous studies have investigated the effects of mercury level on brain morphometry using advance imaging techniques in young adults. Here, utilizing hair analysis which has been advocated as a method for biological monitoring, data of regional gray matter volume (rGMV), regional white matter volume (rWMV), fractional anisotropy (FA) and mean diffusivity (MD), cognitive functions, and depression among 920 healthy young adults in Japan, we showed that greater hair mercury levels were weakly but significantly associated with diminished cognitive performance, particularly on tasks requiring rapid processing (speed measures), lower depressive tendency, lower rGMV in areas of the thalamus and hippocampus, lower rWMV in widespread areas, greater FA in bilaterally distributed white matter areas overlapping with areas of significant rWMV reductions and lower MD of the widely distributed gray and white matter areas particularly in the bilateral frontal lobe and the right basal ganglia. These results suggest that even normal mercury exposure levels in Japan are weakly associated with differences of brain structures and lower neurobehavioral performance and altered mood among young adults." @default.
- W4282002928 created "2022-06-13" @default.
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- W4282002928 date "2022-06-02" @default.
- W4282002928 modified "2023-10-04" @default.
- W4282002928 title "Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults" @default.
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- W4282002928 doi "https://doi.org/10.1038/s42003-022-03464-z" @default.
- W4282002928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35655003" @default.
- W4282002928 hasPublicationYear "2022" @default.
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