Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282005103> ?p ?o ?g. }
- W4282005103 endingPage "e1010609" @default.
- W4282005103 startingPage "e1010609" @default.
- W4282005103 abstract "The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmission of Plasmodium falciparum parasites can be efficiently blocked when exposing Anopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. Here, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. We show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant Anopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. Moreover, this approach prevents transmission of field-derived, artemisinin resistant P . falciparum parasites ( Kelch13 C580Y mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. Atovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. These data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions." @default.
- W4282005103 created "2022-06-13" @default.
- W4282005103 creator A5006905780 @default.
- W4282005103 creator A5011964221 @default.
- W4282005103 creator A5020948164 @default.
- W4282005103 creator A5024078113 @default.
- W4282005103 creator A5030346450 @default.
- W4282005103 creator A5040444533 @default.
- W4282005103 creator A5044753863 @default.
- W4282005103 creator A5058881011 @default.
- W4282005103 creator A5059548173 @default.
- W4282005103 creator A5067554171 @default.
- W4282005103 creator A5073932224 @default.
- W4282005103 creator A5080134164 @default.
- W4282005103 creator A5081523438 @default.
- W4282005103 creator A5082064317 @default.
- W4282005103 creator A5087440676 @default.
- W4282005103 creator A5090293315 @default.
- W4282005103 date "2022-06-10" @default.
- W4282005103 modified "2023-10-18" @default.
- W4282005103 title "Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies" @default.
- W4282005103 cites W1729017034 @default.
- W4282005103 cites W1890992229 @default.
- W4282005103 cites W1965770236 @default.
- W4282005103 cites W1969503178 @default.
- W4282005103 cites W1974527939 @default.
- W4282005103 cites W1976977157 @default.
- W4282005103 cites W1977784023 @default.
- W4282005103 cites W1977845940 @default.
- W4282005103 cites W2020055018 @default.
- W4282005103 cites W2022333447 @default.
- W4282005103 cites W2023224492 @default.
- W4282005103 cites W2025605230 @default.
- W4282005103 cites W2032128070 @default.
- W4282005103 cites W2044461616 @default.
- W4282005103 cites W2053279636 @default.
- W4282005103 cites W2070610132 @default.
- W4282005103 cites W2077141607 @default.
- W4282005103 cites W2080206727 @default.
- W4282005103 cites W2083270871 @default.
- W4282005103 cites W2094260046 @default.
- W4282005103 cites W2095745314 @default.
- W4282005103 cites W2098576362 @default.
- W4282005103 cites W2114296160 @default.
- W4282005103 cites W2120400028 @default.
- W4282005103 cites W2137062868 @default.
- W4282005103 cites W2141976564 @default.
- W4282005103 cites W2145416824 @default.
- W4282005103 cites W2155767317 @default.
- W4282005103 cites W2171102256 @default.
- W4282005103 cites W2171642187 @default.
- W4282005103 cites W2229864756 @default.
- W4282005103 cites W2258834469 @default.
- W4282005103 cites W2337606069 @default.
- W4282005103 cites W2506589757 @default.
- W4282005103 cites W2515892164 @default.
- W4282005103 cites W2517796671 @default.
- W4282005103 cites W2613173822 @default.
- W4282005103 cites W2623263898 @default.
- W4282005103 cites W2803023244 @default.
- W4282005103 cites W2902328751 @default.
- W4282005103 cites W2916899099 @default.
- W4282005103 cites W2954314842 @default.
- W4282005103 cites W2961018688 @default.
- W4282005103 cites W3007190031 @default.
- W4282005103 cites W3016380391 @default.
- W4282005103 cites W3029495153 @default.
- W4282005103 cites W3039236671 @default.
- W4282005103 cites W3046809066 @default.
- W4282005103 cites W3072095047 @default.
- W4282005103 cites W3087096204 @default.
- W4282005103 cites W3089827279 @default.
- W4282005103 cites W3095596738 @default.
- W4282005103 cites W3115838483 @default.
- W4282005103 cites W3117268271 @default.
- W4282005103 cites W3127844335 @default.
- W4282005103 cites W3153238048 @default.
- W4282005103 cites W3154986366 @default.
- W4282005103 cites W3178771838 @default.
- W4282005103 cites W3199856111 @default.
- W4282005103 cites W3200040377 @default.
- W4282005103 doi "https://doi.org/10.1371/journal.ppat.1010609" @default.
- W4282005103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35687594" @default.
- W4282005103 hasPublicationYear "2022" @default.
- W4282005103 type Work @default.
- W4282005103 citedByCount "7" @default.
- W4282005103 countsByYear W42820051032022 @default.
- W4282005103 countsByYear W42820051032023 @default.
- W4282005103 crossrefType "journal-article" @default.
- W4282005103 hasAuthorship W4282005103A5006905780 @default.
- W4282005103 hasAuthorship W4282005103A5011964221 @default.
- W4282005103 hasAuthorship W4282005103A5020948164 @default.
- W4282005103 hasAuthorship W4282005103A5024078113 @default.
- W4282005103 hasAuthorship W4282005103A5030346450 @default.
- W4282005103 hasAuthorship W4282005103A5040444533 @default.
- W4282005103 hasAuthorship W4282005103A5044753863 @default.
- W4282005103 hasAuthorship W4282005103A5058881011 @default.
- W4282005103 hasAuthorship W4282005103A5059548173 @default.