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- W4282005890 endingPage "104486" @default.
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- W4282005890 abstract "Multi-lineage development from gastruloids is enabling unprecedented opportunities to model and study human embryonic processes and is expected to accelerate ex vivo strategies in organ development. Reproducing human cardiogenesis with neurogenesis in a multi-lineage context remains challenging, requiring spatiotemporal input of paracrine and mechanical cues. Here we extend elongating multi-lineage organized (EMLO) gastruloids to include cardiogenesis (EMLOC) and describe interconnected neuro-cardiac lineages in a single gastruloid model. Contractile EMLOCs recapitulate numerous interlinked developmental features including heart tube formation and specialization, cardiomyocyte differentiation and remodeling phases, epicardium, ventricular wall morphogenesis, chamber-like structures and formation of a putative outflow tract. The EMLOC cardiac region, which originates anterior to gut tube primordium, is progressively populated by neurons in a spatial pattern mirroring the known distribution of neurons in the innervated human heart. This human EMLOC model represents a multi-lineage advancement for the study of coincident neurogenesis and cardiogenesis." @default.
- W4282005890 created "2022-06-13" @default.
- W4282005890 creator A5003736772 @default.
- W4282005890 date "2022-06-01" @default.
- W4282005890 modified "2023-10-05" @default.
- W4282005890 title "A combined human gastruloid model of cardiogenesis and neurogenesis" @default.
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- W4282005890 doi "https://doi.org/10.1016/j.isci.2022.104486" @default.
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