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- W4282006332 abstract "Background This study reports the largest transcriptomic analysis of purified CSF cell subpopulations to date. This has relevance for understanding CNS immune surveillance and multiple sclerosis pathogenesis and treatment discovery. Methods CD4+ T-cells were purified from CSF and blood using fluorescence-activated cell sorting, from 21 patients with treatment-naïve multiple sclerosis and 20 individuals with non-inflammatory disorders. Their transcriptomes were profiled through RNA sequencing. A paired comparison was performed between CSF and blood within individuals. A further case-control comparison was performed in an extended cohort of CSF samples. Results Paired comparisons between CD4+ T-cells from CSF and blood identified 5,156 differentially expressed genes in controls and 4,263 differentially expressed in multiple sclerosis patients at false discovery rate (FDR) < 5%. Differential expression analysis of CSF CD4+ T-cells highlighted genes involved in; migration, activation, cholesterol biosynthesis and signalling, including those relevant to multiple sclerosis patho- genesis and treatment. In an extended cohort of multiple sclerosis cases (N=41), analysis of CSF CD4+ T-cells compared with non-inflammatory disorder controls (N = 38) identified 140 differentially expressed genes at FDR < 5%. Conclusion We report numerous gene expression differences between CSF and blood CD4+ T-cells. Identi- fied genes have relevance to multiple sclerosis pathogenesis and could contain novel treatment targets. james.hrastelj@gmail.com" @default.
- W4282006332 created "2022-06-13" @default.
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- W4282006332 date "2022-05-27" @default.
- W4282006332 modified "2023-09-27" @default.
- W4282006332 title "CSF-resident CD4+ T-cells display a distinct gene expression profile relevant to multiple sclerosis" @default.
- W4282006332 doi "https://doi.org/10.1136/jnnp-2022-abn.303" @default.
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