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- W4282008071 abstract "Abstract Introduction Emerging evidence in depression suggests that blood–brain barrier (BBB) breakdown and elevated inflammatory cytokines in states of persistent stress or trauma may contribute to the development of symptoms. Signal‐to‐noise ratio afforded by ultra‐high field MRI may aid in the detection of maladaptations of the glymphatic system related to BBB integrity that may not be visualized at lower field strengths. Methods We investigated the link between glymphatic neuroanatomy via perivascular spaces (PVS) and trauma experience in patients with major depressive disorder (MDD) and in healthy controls using 7‐Tesla MRI and a semi‐automated segmentation algorithm. Results After controlling for age and gender, the number of traumatic events was correlated with total PVS volume in MDD patients ( r = 0.50, p = .028) and the overall population ( r = 0.34, p = .024). The number of traumatic events eliciting horror was positively correlated with total PVS volume in MDD patients ( r = 0.50, p = .030) and the overall population ( r = 0.32, p = .023). Age correlated positively with PVS count, PVS total volume, and PVS density in all participants ( r > 0.35, p < .01). Conclusions These results suggest a relationship between glymphatic dysfunction related to BBB integrity and psychological trauma, and that glymphatic impairment may play a role in trauma‐related symptomatology." @default.
- W4282008071 created "2022-06-13" @default.
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- W4282008071 date "2022-06-07" @default.
- W4282008071 modified "2023-09-27" @default.
- W4282008071 title "Perivascular spaces as a marker of psychological trauma in depression: A 7‐Tesla MRI study" @default.
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- W4282008071 doi "https://doi.org/10.1002/brb3.2598" @default.
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