Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282012287> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4282012287 endingPage "88" @default.
- W4282012287 startingPage "84" @default.
- W4282012287 abstract "Although several reports recommend the use of systemic anticoagulation therapy in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, appropriate target population and timing of administration are unknown. We assessed association between therapeutic anticoagulation administration with unfractionated heparin and outcomes in patients with severe COVID-19 pneumonia, assuming that anticoagulant administration effects are influenced by therapy timing.This retrospective observational study included severe COVID-19 patients requiring mechanical ventilation in a tertiary emergency critical care hospital intensive care unit (ICU) in Japan from May 1, 2020 to September 30, 2021. All included patients were divided into early and late-phase administration groups based on therapeutic anticoagulant administration timing (≤5 and >5 days, respectively, after commencing oxygen therapy). Primary outcomes (in-hospital mortality and adverse events related to anticoagulation therapy) and secondary outcomes [veno-venous extracorporeal membrane oxygenation (ECMO), ventilator-free days (VFD), and ICU-free days] were compared between groups using univariate and multivariate models.Of 198 included patients 104 (52.5%) and 94 (47.5%) were in early-phase and late-phase administration groups, respectively. Although background characteristics were similar between the groups, the early-phase administration group had a significantly lower in-hospital mortality rate (3.8% vs. 27.7%; p < 0.001), lower adverse event rates (1.9% vs. 12.8%; p < 0.001), significantly longer VFD and ICU-free days, and lower ECMO rates, than the late-phase administration group, in the multivariate model.Late administration of therapeutic-dose anticoagulation in patients with severe COVID-19 pneumonia was significantly associated with worse outcomes than early administration." @default.
- W4282012287 created "2022-06-13" @default.
- W4282012287 creator A5035735112 @default.
- W4282012287 creator A5044665467 @default.
- W4282012287 creator A5065790953 @default.
- W4282012287 date "2022-08-01" @default.
- W4282012287 modified "2023-09-25" @default.
- W4282012287 title "Therapeutic anticoagulation using heparin in early phase severe coronavirus disease 2019: A retrospective study" @default.
- W4282012287 cites W2000445173 @default.
- W4282012287 cites W2020613436 @default.
- W4282012287 cites W2038032151 @default.
- W4282012287 cites W2280404143 @default.
- W4282012287 cites W2567022534 @default.
- W4282012287 cites W3001118548 @default.
- W4282012287 cites W3008461878 @default.
- W4282012287 cites W3009885589 @default.
- W4282012287 cites W3012421327 @default.
- W4282012287 cites W3016555942 @default.
- W4282012287 cites W3018782743 @default.
- W4282012287 cites W3019613751 @default.
- W4282012287 cites W3020168167 @default.
- W4282012287 cites W3027918021 @default.
- W4282012287 cites W3028615142 @default.
- W4282012287 cites W3042021285 @default.
- W4282012287 cites W3087271626 @default.
- W4282012287 cites W3088960741 @default.
- W4282012287 cites W3092252175 @default.
- W4282012287 cites W3094213933 @default.
- W4282012287 cites W3095089792 @default.
- W4282012287 cites W3121319444 @default.
- W4282012287 cites W3128604271 @default.
- W4282012287 cites W3171400183 @default.
- W4282012287 cites W4205922819 @default.
- W4282012287 cites W4226000943 @default.
- W4282012287 cites W4231969161 @default.
- W4282012287 doi "https://doi.org/10.1016/j.ajem.2022.05.031" @default.
- W4282012287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35640454" @default.
- W4282012287 hasPublicationYear "2022" @default.
- W4282012287 type Work @default.
- W4282012287 citedByCount "0" @default.
- W4282012287 crossrefType "journal-article" @default.
- W4282012287 hasAuthorship W4282012287A5035735112 @default.
- W4282012287 hasAuthorship W4282012287A5044665467 @default.
- W4282012287 hasAuthorship W4282012287A5065790953 @default.
- W4282012287 hasBestOaLocation W42820122871 @default.
- W4282012287 hasConcept C126322002 @default.
- W4282012287 hasConcept C167135981 @default.
- W4282012287 hasConcept C197934379 @default.
- W4282012287 hasConcept C2776376669 @default.
- W4282012287 hasConcept C2776858399 @default.
- W4282012287 hasConcept C2777080012 @default.
- W4282012287 hasConcept C2777557582 @default.
- W4282012287 hasConcept C2777914695 @default.
- W4282012287 hasConcept C2908647359 @default.
- W4282012287 hasConcept C42219234 @default.
- W4282012287 hasConcept C71924100 @default.
- W4282012287 hasConcept C99454951 @default.
- W4282012287 hasConceptScore W4282012287C126322002 @default.
- W4282012287 hasConceptScore W4282012287C167135981 @default.
- W4282012287 hasConceptScore W4282012287C197934379 @default.
- W4282012287 hasConceptScore W4282012287C2776376669 @default.
- W4282012287 hasConceptScore W4282012287C2776858399 @default.
- W4282012287 hasConceptScore W4282012287C2777080012 @default.
- W4282012287 hasConceptScore W4282012287C2777557582 @default.
- W4282012287 hasConceptScore W4282012287C2777914695 @default.
- W4282012287 hasConceptScore W4282012287C2908647359 @default.
- W4282012287 hasConceptScore W4282012287C42219234 @default.
- W4282012287 hasConceptScore W4282012287C71924100 @default.
- W4282012287 hasConceptScore W4282012287C99454951 @default.
- W4282012287 hasLocation W42820122871 @default.
- W4282012287 hasLocation W42820122872 @default.
- W4282012287 hasLocation W42820122873 @default.
- W4282012287 hasOpenAccess W4282012287 @default.
- W4282012287 hasPrimaryLocation W42820122871 @default.
- W4282012287 hasRelatedWork W1651394837 @default.
- W4282012287 hasRelatedWork W2009263326 @default.
- W4282012287 hasRelatedWork W2041740107 @default.
- W4282012287 hasRelatedWork W2335083976 @default.
- W4282012287 hasRelatedWork W2379207176 @default.
- W4282012287 hasRelatedWork W3016419989 @default.
- W4282012287 hasRelatedWork W3117573775 @default.
- W4282012287 hasRelatedWork W3129568388 @default.
- W4282012287 hasRelatedWork W3146714785 @default.
- W4282012287 hasRelatedWork W3147370169 @default.
- W4282012287 hasVolume "58" @default.
- W4282012287 isParatext "false" @default.
- W4282012287 isRetracted "false" @default.
- W4282012287 workType "article" @default.