FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282013054> ?p ?o ?g. }

• W4282013054 endingPage "10" @default.
• W4282013054 startingPage "1" @default.
• W4282013054 abstract "Male C57BL/6J mice were randomly divided into six different experimental groups (8 animals/group): (1) normal group (NOR), (2) normal control group (NC), (3) normal + exercise group (NE), (4) IGT group (IGT), (5) IGT control group (IC), and (6) IGT+ exercise group (IE).The exercise group received aerobic exercise for 8 weeks. After the intervention, a blood glucose meter was used to detect the level of glucose tolerance in the mouse's abdominal cavity; a biochemical kit was used to detect serum lipid metabolism indicators, malondialdehyde, and superoxide dismutase levels; the ELISA method was used to detect serum insulin and mouse gastrocnemius homogenate LDH, PDH, SDH, and CCO levels. Western blot method was used to detect the protein expression levels of NOX4, PGC-1α, and Mfn2 in the gastrocnemius muscle of mice.(1) Mice with high-fat diet for 30 weeks showed impaired glucose tolerance, insulin resistance, and lipid metabolism disorders. The level of LDH, PDH, SDH, and CCO in the gastrocnemius homogenate of mice was reduced. The expressions of NOX4 protein were significantly upregulated, while the expressions of PGC-1α and Mfn2 proteins were significantly downregulated. (2) 8-week aerobic exercise improved the disorders of glucose and lipid metabolism in IGT mice and increased homogenized LDH, PDH, SDH, and CCO levels, and the expressions of NOX4, PGC-1α, and Mfn2 proteins in the gastrocnemius muscle of mice were reversed. It is speculated that aerobic exercise can accelerate energy metabolism.(1) C57BL/6 mice were fed high fat for 30 weeks and successfully constructed a mouse model of reduced diabetes; the mice with reduced diabetes have impaired glucose tolerance, insulin resistance, and lipid metabolism disorders; (2) 8 weeks of aerobic exercise improve glucose tolerance, reduce glucose tolerance in mice, reduce insulin resistance, improve lipid metabolism disorders, and reduce oxidative stress; (3) 8-week aerobic exercise reduces skeletal muscle NOX4 expression and increases glucose tolerance; reduces the expression of LDH, PDH, SDH, and CCO in mouse skeletal muscle; increases the expression level of mitochondrial fusion protein 2 and PGC-1α; improves glucose tolerance; reduces energy metabolism of mouse skeletal muscle; reduces oxidative stress; and reduces insulin resistance. It is speculated that aerobic exercise can accelerate energy metabolism. This process may involve two aspects: firstly, increase the expression level of oxidative metabolism enzymes and promote the tricarboxylic acid cycle; secondly, increase the expression of Mfn2 and accelerate mitochondria fission or fusion to regulate energy metabolism, thereby reducing oxidative stress and insulin resistance." @default.
• W4282013054 created "2022-06-13" @default.
• W4282013054 creator A5001842929 @default.
• W4282013054 creator A5008075237 @default.
• W4282013054 creator A5018612461 @default.
• W4282013054 creator A5034480030 @default.
• W4282013054 creator A5055385594 @default.
• W4282013054 creator A5062187564 @default.
• W4282013054 creator A5063847940 @default.
• W4282013054 creator A5076402986 @default.
• W4282013054 date "2022-06-07" @default.
• W4282013054 modified "2023-09-27" @default.
• W4282013054 title "The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance" @default.
• W4282013054 cites W1523158326 @default.
• W4282013054 cites W1867325796 @default.
• W4282013054 cites W1964619095 @default.
• W4282013054 cites W1966029580 @default.
• W4282013054 cites W1995004764 @default.
• W4282013054 cites W1995381409 @default.
• W4282013054 cites W2003416763 @default.
• W4282013054 cites W2006754278 @default.
• W4282013054 cites W2009918956 @default.
• W4282013054 cites W2012962820 @default.
• W4282013054 cites W2014671368 @default.
• W4282013054 cites W2019455536 @default.
• W4282013054 cites W2030608745 @default.
• W4282013054 cites W2032264012 @default.
• W4282013054 cites W2032451121 @default.
• W4282013054 cites W2041061895 @default.
• W4282013054 cites W2053765200 @default.
• W4282013054 cites W2067943472 @default.
• W4282013054 cites W2069466682 @default.
• W4282013054 cites W2070251076 @default.
• W4282013054 cites W2078613558 @default.
• W4282013054 cites W2086557228 @default.
• W4282013054 cites W2090711760 @default.
• W4282013054 cites W2090843323 @default.
• W4282013054 cites W2100378647 @default.
• W4282013054 cites W2106830005 @default.
• W4282013054 cites W2108453323 @default.
• W4282013054 cites W2109879006 @default.
• W4282013054 cites W2121198137 @default.
• W4282013054 cites W2124903818 @default.
• W4282013054 cites W2127806759 @default.
• W4282013054 cites W2134613826 @default.
• W4282013054 cites W2137012624 @default.
• W4282013054 cites W2137580945 @default.
• W4282013054 cites W2145490597 @default.
• W4282013054 cites W2150474735 @default.
• W4282013054 cites W2163710303 @default.
• W4282013054 cites W2165096496 @default.
• W4282013054 cites W2166432730 @default.
• W4282013054 cites W2166954428 @default.
• W4282013054 cites W2167398654 @default.
• W4282013054 cites W2169835146 @default.
• W4282013054 cites W2170869159 @default.
• W4282013054 cites W2206895063 @default.
• W4282013054 cites W2350961718 @default.
• W4282013054 cites W2525933343 @default.
• W4282013054 cites W2534750259 @default.
• W4282013054 cites W2572344066 @default.
• W4282013054 cites W2589290067 @default.
• W4282013054 cites W2605401406 @default.
• W4282013054 cites W2772652559 @default.
• W4282013054 cites W2887148828 @default.
• W4282013054 cites W2887388617 @default.
• W4282013054 cites W2920001649 @default.
• W4282013054 cites W2978810474 @default.
• W4282013054 cites W3002345594 @default.
• W4282013054 cites W3013395541 @default.
• W4282013054 cites W3015068940 @default.
• W4282013054 cites W3086072956 @default.
• W4282013054 cites W4205788778 @default.
• W4282013054 cites W4220937216 @default.
• W4282013054 cites W4241031718 @default.
• W4282013054 doi "https://doi.org/10.1155/2022/3780156" @default.
• W4282013054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35712028" @default.
• W4282013054 hasPublicationYear "2022" @default.
• W4282013054 type Work @default.
• W4282013054 citedByCount "2" @default.
• W4282013054 countsByYear W42820130542023 @default.
• W4282013054 crossrefType "journal-article" @default.
• W4282013054 hasAuthorship W4282013054A5001842929 @default.
• W4282013054 hasAuthorship W4282013054A5008075237 @default.
• W4282013054 hasAuthorship W4282013054A5018612461 @default.
• W4282013054 hasAuthorship W4282013054A5034480030 @default.
• W4282013054 hasAuthorship W4282013054A5055385594 @default.
• W4282013054 hasAuthorship W4282013054A5062187564 @default.
• W4282013054 hasAuthorship W4282013054A5063847940 @default.
• W4282013054 hasAuthorship W4282013054A5076402986 @default.
• W4282013054 hasBestOaLocation W42820130541 @default.
• W4282013054 hasConcept C103038586 @default.
• W4282013054 hasConcept C104317684 @default.
• W4282013054 hasConcept C126322002 @default.
• W4282013054 hasConcept C134018914 @default.
• W4282013054 hasConcept C17093226 @default.
• W4282013054 hasConcept C185592680 @default.
• W4282013054 hasConcept C2775872116 @default.

• next