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• W4282014553 endingPage "2722" @default.
• W4282014553 startingPage "2713" @default.
• W4282014553 abstract "Secretome is involved in almost all physiological, developmental, and pathological processes, but to date there is still a lack of highly-efficient research strategy to comprehensively study the secretome of invertebrates. Adhesive secretion is a ubiquitous and essential physiological process in aquatic invertebrates with complicated protein components and unresolved adhesion mechanisms, making it a good subject for secretome profiling studies. Here we proposed a computational pipeline for systematic profiling of byssal secretome based on spatiotemporal transcriptomes of scallop. A total of 186 byssus-related proteins (BRPs) were identified, which represented the first characterized secretome of scallop byssal adhesion. Scallop byssal secretome covered almost all of the known structural elements and functional domains of aquatic adhesives, which suggested this secretome-profiling strategy had both high efficiency and accuracy. We revealed the main components of scallop byssus (including EGF-like domain containing proteins, the Tyr-rich proteins and 4C-repeats containing proteins) and the related modification enzymes primarily contributing to the rapid byssus assembly and adhesion. Spatiotemporal expression and co-expression network analyses of BRPs suggested a simultaneous secretion pattern of scallop byssal proteins across the entire region of foot and revealed their diverse functions on byssus secretion. In contrast to the previously proposed root-initiated secretion and extension-based assembly model, our findings supported a novel foot-wide simultaneous secretion and in situ assembly model of scallop byssus secretion and adhesion. Systematic analysis of scallop byssal secretome provides important clues for understanding the aquatic adhesive secretion process, as well as a common framework for studying the secretome of non-model invertebrates." @default.
• W4282014553 created "2022-06-13" @default.
• W4282014553 creator A5007671941 @default.
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• W4282014553 creator A5080456763 @default.
• W4282014553 date "2022-01-01" @default.
• W4282014553 modified "2023-09-30" @default.
• W4282014553 title "Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot" @default.
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