FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282016514> ?p ?o ?g. }

• W4282016514 endingPage "116452" @default.
• W4282016514 startingPage "116452" @default.
• W4282016514 abstract "Among the interventions used to prevent osteoporosis in female organisms, strength training (ST) and oxytocin (OT) stand out, as a promising hormone with anabolic action on bone. This study aimed to verify whether the combined action of OT and ST, compared to isolated interventions, potentiates the bone remodeling process of the femoral neck of Wistar rats during periestropause. Forty Wistar rats (18 months) with irregular estrous cycle were randomly distributed into groups: 1-Vehicle (Veh; NaCl 0.15 mol/L ip); 2-Oxytocin (Ot; 134 μg/kg/ip); 3-Strength training (St); 4-Ot + St. The animals of the 1, 2 and 4 groups received two intraperitoneal injections with an interval of 12 h every 30 days, totaling 8 injections at the end of the experimental period (18 to 21 months). The animals in the St and Ot + St groups performed ST on a ladder 3 times a week, maximal voluntary carrying capacity (MVCC) test monthly. After 120 days, the animals were euthanized; the femur was collected for analysis of biomechanical testing, densitometry, bone microtomography, Raman spectroscopy, tissue PCR, and blood for analysis of bone biomarkers, liver damage, and oxidative stress. The main effects in the Ot group were observed in the maximum load and energy in the compression testing (femoral head), and stiffness and energy in the three-points bending testing (femur diaphysis). In addition, the main effects occurred on the bone mineral density (BMD), cortical thickness (Ct.Th), number of pores (Po.N), polar moment of inertia (J), trabecular thickness (Tb.Th), and connectivity density (Conn.Dn), Bone alkaline phosphatase (Alp), Tumor necrosis factor receptor superfamily member 11b (Opg), Tumor necrosis factor ligand superfamily member 11 (Rankl) and Cathepsin K (Ctsk) expression. There was an effect in the tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP). In the St group, the main effect was observed on the energy (compression and the three-points bending), stiffness, aBMD, BMD, cortical bone area (Ct.Ar), Po.N, trabecular bone volume (BV/TV), Tb.Th and in the mineralization ratio (ѵ1PO4/proline), Runt-related transcription factor 2 (Runx2), Bone morphogenetic protein 2 (Bmp2), Alp, Osteopontin/secreted phosphoprotein 1 (Opn/Spp1), Opg, Tumor necrosis factor receptor superfamily member 11ª (Rank), Rankl, Ctsk expression. There was an effect in the TRAP and ALP. The interaction in the combination of therapies in the Ot + St group was verified in energy to maximum load (compression and three-points bending testing), stiffness, BMD, Ct.Th, J, Tb.Th and ѵ1PO4/proline. In the gene analysis there was interaction in the Runx2, Osterix/Sp7 transcription factor (Osx/Sp7), Bmp2, Alp, Osteocalcin/Bone gamma-carboxyglutamate protein (Ocn/Bglap), Opg, Rankl and Acid phosphatase 5, tartrate resistant (Trap/Acp5) expression. In addition, the combination of OT and ST resulted in a higher maximum load compared to the Veh group, with higher BV/TV than the Ot group, higher Rankl and Ctsk expression than Veh and Ot groups, and lower Po.N and lower activity of TRAP than the other groups. In oxidative stress, total antioxidant capacity (TAC) was lower. These results showed that the combination of interventions is a promising anabolic strategy for the prevention of osteoporosis in the period of periestropause, standing out from the effects of isolated interventions." @default.
• W4282016514 created "2022-06-13" @default.
• W4282016514 creator A5000845636 @default.
• W4282016514 creator A5009491094 @default.
• W4282016514 creator A5046924701 @default.
• W4282016514 creator A5051384835 @default.
• W4282016514 creator A5059215535 @default.
• W4282016514 creator A5068300606 @default.
• W4282016514 creator A5075870381 @default.
• W4282016514 creator A5076520066 @default.
• W4282016514 creator A5035394421 @default.
• W4282016514 date "2022-09-01" @default.
• W4282016514 modified "2023-10-06" @default.
• W4282016514 title "Analysis of the femoral neck from rats in the periestropause treated with oxytocin and submitted to strength training" @default.
• W4282016514 cites W1975953388 @default.
• W4282016514 cites W1977409318 @default.
• W4282016514 cites W1996161852 @default.
• W4282016514 cites W2012205421 @default.
• W4282016514 cites W2018038256 @default.
• W4282016514 cites W2032752377 @default.
• W4282016514 cites W2038145443 @default.
• W4282016514 cites W2041762053 @default.
• W4282016514 cites W2066749771 @default.
• W4282016514 cites W2068155003 @default.
• W4282016514 cites W2078628715 @default.
• W4282016514 cites W2092238408 @default.
• W4282016514 cites W2107277218 @default.
• W4282016514 cites W2112225240 @default.
• W4282016514 cites W2117883524 @default.
• W4282016514 cites W2125369584 @default.
• W4282016514 cites W2125538936 @default.
• W4282016514 cites W2152150454 @default.
• W4282016514 cites W2153763891 @default.
• W4282016514 cites W2154807814 @default.
• W4282016514 cites W2165292984 @default.
• W4282016514 cites W2169887586 @default.
• W4282016514 cites W2176301335 @default.
• W4282016514 cites W2251108268 @default.
• W4282016514 cites W2263434320 @default.
• W4282016514 cites W2337881242 @default.
• W4282016514 cites W2467586416 @default.
• W4282016514 cites W2589571124 @default.
• W4282016514 cites W2598553155 @default.
• W4282016514 cites W2771936811 @default.
• W4282016514 cites W2807165335 @default.
• W4282016514 cites W2888028761 @default.
• W4282016514 cites W2897945762 @default.
• W4282016514 cites W2935451440 @default.
• W4282016514 cites W2968464619 @default.
• W4282016514 cites W2982132029 @default.
• W4282016514 cites W3005910583 @default.
• W4282016514 cites W3008223248 @default.
• W4282016514 cites W3027026505 @default.
• W4282016514 cites W3033131456 @default.
• W4282016514 cites W3081096951 @default.
• W4282016514 cites W3095530934 @default.
• W4282016514 cites W584794406 @default.
• W4282016514 doi "https://doi.org/10.1016/j.bone.2022.116452" @default.
• W4282016514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35654351" @default.
• W4282016514 hasPublicationYear "2022" @default.
• W4282016514 type Work @default.
• W4282016514 citedByCount "3" @default.
• W4282016514 countsByYear W42820165142023 @default.
• W4282016514 crossrefType "journal-article" @default.
• W4282016514 hasAuthorship W4282016514A5000845636 @default.
• W4282016514 hasAuthorship W4282016514A5009491094 @default.
• W4282016514 hasAuthorship W4282016514A5035394421 @default.
• W4282016514 hasAuthorship W4282016514A5046924701 @default.
• W4282016514 hasAuthorship W4282016514A5051384835 @default.
• W4282016514 hasAuthorship W4282016514A5059215535 @default.
• W4282016514 hasAuthorship W4282016514A5068300606 @default.
• W4282016514 hasAuthorship W4282016514A5075870381 @default.
• W4282016514 hasAuthorship W4282016514A5076520066 @default.
• W4282016514 hasConcept C105702510 @default.
• W4282016514 hasConcept C126322002 @default.
• W4282016514 hasConcept C134018914 @default.
• W4282016514 hasConcept C141071460 @default.
• W4282016514 hasConcept C1862650 @default.
• W4282016514 hasConcept C2775854910 @default.
• W4282016514 hasConcept C2776176026 @default.
• W4282016514 hasConcept C2776541429 @default.
• W4282016514 hasConcept C2776868573 @default.
• W4282016514 hasConcept C2776886416 @default.
• W4282016514 hasConcept C2780554211 @default.
• W4282016514 hasConcept C2781451080 @default.
• W4282016514 hasConcept C71924100 @default.
• W4282016514 hasConceptScore W4282016514C105702510 @default.
• W4282016514 hasConceptScore W4282016514C126322002 @default.
• W4282016514 hasConceptScore W4282016514C134018914 @default.
• W4282016514 hasConceptScore W4282016514C141071460 @default.
• W4282016514 hasConceptScore W4282016514C1862650 @default.
• W4282016514 hasConceptScore W4282016514C2775854910 @default.
• W4282016514 hasConceptScore W4282016514C2776176026 @default.
• W4282016514 hasConceptScore W4282016514C2776541429 @default.
• W4282016514 hasConceptScore W4282016514C2776868573 @default.
• W4282016514 hasConceptScore W4282016514C2776886416 @default.
• W4282016514 hasConceptScore W4282016514C2780554211 @default.
• W4282016514 hasConceptScore W4282016514C2781451080 @default.

• next