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- W4282020160 abstract "Antineutrophil cytoplasmic antibodies (<abbrev>ANCAs</abbrev>) are serum tests used to aid in the diagnosis of <abbrev>ANCA</abbrev>-associated vasculitis (<abbrev>AAV</abbrev>). <abbrev>AAV</abbrev> refers to a group of disorders which affect the small blood vessels (capillaries, arterioles, and venules) and are defined by leukocyte migration to blood vessel walls with resultant damage. The main antigenic targets of <abbrev>ANCAs</abbrev> are proteinase 3 (<abbrev>PR3</abbrev>), a protease, and myeloperoxidase (<abbrev>MPO</abbrev>), a lysosomal enzyme. There are two <abbrev>ANCA</abbrev> assays widely used in commercial laboratories: indirect immunofluorescence (<abbrev>IA</abbrev>) and enzyme-linked immunosorbent (<abbrev>ELISA</abbrev>). In patients with <abbrev>AAV</abbrev>, which antibody is positive may indicate the manifestations the disease is likely to exhibit. Patients who are <abbrev>PR3</abbrev>-<abbrev>ANCA</abbrev> positive are more likely to have ear, nose, throat, and respiratory tract disease. This test is referred to as cytoplasmic <abbrev>ANCA</abbrev> (<abbrev>C-ANCA</abbrev>). Patients who are <abbrev>MPO</abbrev>-<abbrev>ANCA</abbrev> positive are more likely to have renal, cutaneous, and pulmonary disease. <abbrev>MPO</abbrev>-<abbrev>ANCA</abbrev> is also referred to as perinuclear <abbrev>ANCA</abbrev> (<abbrev>P-ANCA</abbrev>)." @default.
- W4282020160 created "2022-06-13" @default.
- W4282020160 creator A5033533727 @default.
- W4282020160 date "2022-04-01" @default.
- W4282020160 modified "2023-10-18" @default.
- W4282020160 title "Antineutrophil Cytoplasmic Antibodies" @default.
- W4282020160 doi "https://doi.org/10.1891/9780826188434.0022" @default.
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