FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282024674> ?p ?o ?g. }

• W4282024674 endingPage "133486" @default.
• W4282024674 startingPage "133486" @default.
• W4282024674 abstract "Cobalt complexes had exhibited the potential anti-diabetes abilities, but the mechanism is not so clear now. In this work, we synthesized and characterized a new cobalt(II) complex [Co(L)2Cl2]·1.5CH3OH·H2O (L=4-{[3-(pyridine-2-yl)-1H-pyrazol-1-yl]methyl}-benzoic acid). The crystal structure determination shows that the complex crystallizes in the triclinic system with P1¯ space group, where Co(II) center of the complex resides in a distorted octahedron with four N atoms from two pyridine-pyrazole ligands and two Cl− anions in a cis-configuration. The structure cohesion is ensured by intermolecular hydrogen bonds and intramolecular π···π stack interactions. Such a cobalt(II) complex shows moderate inhibition activity (IC50 = 35.6 µM) against T-cell protein tyrosine phosphatase (TCPTP), a potential target for therapy of diabetes. We speculate that the anti-diabetes ability of the cobalt complex may play its role by inhibiting the activity of TCPTP. Moreover, the MTT assays reveal that the complex exhibits relatively low cytotoxicity to cancer cell lines (MCF7, HepG2, and SW480) and the normal cell line (HL-7702)." @default.
• W4282024674 created "2022-06-13" @default.
• W4282024674 creator A5002586734 @default.
• W4282024674 creator A5004512881 @default.
• W4282024674 creator A5009815822 @default.
• W4282024674 creator A5028497001 @default.
• W4282024674 creator A5029352950 @default.
• W4282024674 creator A5043115897 @default.
• W4282024674 creator A5068255769 @default.
• W4282024674 creator A5086592352 @default.
• W4282024674 creator A5088913213 @default.
• W4282024674 date "2022-10-01" @default.
• W4282024674 modified "2023-10-14" @default.
• W4282024674 title "Crystal structure, TCPTP inhibition and cytotoxicity of the cobalt(II) complex with the 4‐{[3‐(pyridine‐2‐yl)‐1H‐pyrazol‐1‐yl]methyl}‐benzoic acid ligand" @default.
• W4282024674 cites W1762366815 @default.
• W4282024674 cites W1819645169 @default.
• W4282024674 cites W1971849102 @default.
• W4282024674 cites W1977857020 @default.
• W4282024674 cites W2004842317 @default.
• W4282024674 cites W2017702218 @default.
• W4282024674 cites W2031686214 @default.
• W4282024674 cites W2033411302 @default.
• W4282024674 cites W2068770928 @default.
• W4282024674 cites W2077768291 @default.
• W4282024674 cites W2102547716 @default.
• W4282024674 cites W2125198954 @default.
• W4282024674 cites W2131350133 @default.
• W4282024674 cites W2150697053 @default.
• W4282024674 cites W2158844801 @default.
• W4282024674 cites W2161400495 @default.
• W4282024674 cites W2328765999 @default.
• W4282024674 cites W2563983404 @default.
• W4282024674 cites W2799467504 @default.
• W4282024674 cites W2934528811 @default.
• W4282024674 cites W2990036538 @default.
• W4282024674 cites W2992052584 @default.
• W4282024674 cites W3007172706 @default.
• W4282024674 cites W3117839565 @default.
• W4282024674 cites W3120225770 @default.
• W4282024674 cites W3123891920 @default.
• W4282024674 cites W3127701518 @default.
• W4282024674 cites W3135841838 @default.
• W4282024674 cites W3169939757 @default.
• W4282024674 cites W3173635599 @default.
• W4282024674 cites W3212635861 @default.
• W4282024674 doi "https://doi.org/10.1016/j.molstruc.2022.133486" @default.
• W4282024674 hasPublicationYear "2022" @default.
• W4282024674 type Work @default.
• W4282024674 citedByCount "0" @default.
• W4282024674 crossrefType "journal-article" @default.
• W4282024674 hasAuthorship W4282024674A5002586734 @default.
• W4282024674 hasAuthorship W4282024674A5004512881 @default.
• W4282024674 hasAuthorship W4282024674A5009815822 @default.
• W4282024674 hasAuthorship W4282024674A5028497001 @default.
• W4282024674 hasAuthorship W4282024674A5029352950 @default.
• W4282024674 hasAuthorship W4282024674A5043115897 @default.
• W4282024674 hasAuthorship W4282024674A5068255769 @default.
• W4282024674 hasAuthorship W4282024674A5086592352 @default.
• W4282024674 hasAuthorship W4282024674A5088913213 @default.
• W4282024674 hasConcept C112887158 @default.
• W4282024674 hasConcept C115624301 @default.
• W4282024674 hasConcept C116569031 @default.
• W4282024674 hasConcept C155647269 @default.
• W4282024674 hasConcept C170493617 @default.
• W4282024674 hasConcept C178790620 @default.
• W4282024674 hasConcept C179104552 @default.
• W4282024674 hasConcept C185592680 @default.
• W4282024674 hasConcept C2778844314 @default.
• W4282024674 hasConcept C2779485729 @default.
• W4282024674 hasConcept C32909587 @default.
• W4282024674 hasConcept C39297587 @default.
• W4282024674 hasConcept C515602321 @default.
• W4282024674 hasConcept C55493867 @default.
• W4282024674 hasConcept C71240020 @default.
• W4282024674 hasConcept C75079739 @default.
• W4282024674 hasConcept C8010536 @default.
• W4282024674 hasConceptScore W4282024674C112887158 @default.
• W4282024674 hasConceptScore W4282024674C115624301 @default.
• W4282024674 hasConceptScore W4282024674C116569031 @default.
• W4282024674 hasConceptScore W4282024674C155647269 @default.
• W4282024674 hasConceptScore W4282024674C170493617 @default.
• W4282024674 hasConceptScore W4282024674C178790620 @default.
• W4282024674 hasConceptScore W4282024674C179104552 @default.
• W4282024674 hasConceptScore W4282024674C185592680 @default.
• W4282024674 hasConceptScore W4282024674C2778844314 @default.
• W4282024674 hasConceptScore W4282024674C2779485729 @default.
• W4282024674 hasConceptScore W4282024674C32909587 @default.
• W4282024674 hasConceptScore W4282024674C39297587 @default.
• W4282024674 hasConceptScore W4282024674C515602321 @default.
• W4282024674 hasConceptScore W4282024674C55493867 @default.
• W4282024674 hasConceptScore W4282024674C71240020 @default.
• W4282024674 hasConceptScore W4282024674C75079739 @default.
• W4282024674 hasConceptScore W4282024674C8010536 @default.
• W4282024674 hasLocation W42820246741 @default.
• W4282024674 hasOpenAccess W4282024674 @default.
• W4282024674 hasPrimaryLocation W42820246741 @default.
• W4282024674 hasRelatedWork W1907476115 @default.
• W4282024674 hasRelatedWork W2034230510 @default.

• next