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• W4282024710 abstract "Abstract The host’s gene expression and gene regulatory response to pathogen exposure can be influenced by a combination of the host’s genetic background, the type of and exposure time to pathogens. Here we provide a detailed dissection of this using single-cell RNA-sequencing of 1.3M peripheral blood mononuclear cells from 120 individuals, longitudinally exposed to three different pathogens. These analyses indicate that cell-type-specificity is a more prominent factor than pathogen-specificity regarding contexts that affect how genetics influences gene expression (i.e., eQTL) and co-expression (i.e., co-expression QTL). In monocytes, the strongest responder to pathogen stimulations, 71.4% of the genetic variants whose effect on gene expression is influenced by pathogen exposure (i.e., response QTL) also affect the co-expression between genes. This indicates widespread, context-specific changes in gene expression level and its regulation that are driven by genetics. Pathway analysis on the CLEC12A gene that exemplifies cell-type-, exposure-time- and genetic-background-dependent co-expression interactions, shows enrichment of the interferon (IFN) pathway specifically at 3-h post-exposure in monocytes. Similar genetic background-dependent association between IFN activity and CLEC12A co-expression patterns is confirmed in systemic lupus erythematosus by in silico analysis, which implies that CLEC12A might be an IFN-regulated gene. Altogether, this study highlights the importance of context for gaining a better understanding of the mechanisms of gene regulation in health and disease." @default.
• W4282024710 created "2022-06-13" @default.
• W4282024710 creator A5005819504 @default.
• W4282024710 creator A5024552119 @default.
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• W4282024710 creator A5051318591 @default.
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• W4282024710 creator A5065704289 @default.
• W4282024710 creator A5082560822 @default.
• W4282024710 date "2022-06-07" @default.
• W4282024710 modified "2023-10-16" @default.
• W4282024710 title "Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure" @default.
• W4282024710 cites W1587447328 @default.
• W4282024710 cites W1740564681 @default.
• W4282024710 cites W1896868877 @default.
• W4282024710 cites W1975528320 @default.
• W4282024710 cites W1975705143 @default.
• W4282024710 cites W1987799551 @default.
• W4282024710 cites W1989590412 @default.
• W4282024710 cites W2009178411 @default.
• W4282024710 cites W2012697072 @default.
• W4282024710 cites W2043012291 @default.
• W4282024710 cites W2057406395 @default.
• W4282024710 cites W2058454627 @default.
• W4282024710 cites W2072723458 @default.
• W4282024710 cites W2077955816 @default.
• W4282024710 cites W2079279399 @default.
• W4282024710 cites W2083051190 @default.
• W4282024710 cites W2083380010 @default.
• W4282024710 cites W2088052489 @default.
• W4282024710 cites W2093304538 @default.
• W4282024710 cites W2100704940 @default.
• W4282024710 cites W2101280135 @default.
• W4282024710 cites W2104549677 @default.
• W4282024710 cites W2123367066 @default.
• W4282024710 cites W2124649657 @default.
• W4282024710 cites W2130419890 @default.
• W4282024710 cites W2134783591 @default.
• W4282024710 cites W2135030836 @default.
• W4282024710 cites W2135199713 @default.
• W4282024710 cites W2135373024 @default.
• W4282024710 cites W2141711435 @default.
• W4282024710 cites W2163749231 @default.
• W4282024710 cites W2190545194 @default.
• W4282024710 cites W2259159922 @default.
• W4282024710 cites W2284521682 @default.
• W4282024710 cites W2321809676 @default.
• W4282024710 cites W2324838759 @default.
• W4282024710 cites W2335818455 @default.
• W4282024710 cites W2497202960 @default.
• W4282024710 cites W2509783789 @default.
• W4282024710 cites W2547161721 @default.
• W4282024710 cites W2559699708 @default.
• W4282024710 cites W2571503386 @default.
• W4282024710 cites W2604301236 @default.
• W4282024710 cites W2725988230 @default.
• W4282024710 cites W2756042645 @default.
• W4282024710 cites W2770092353 @default.
• W4282024710 cites W2774307122 @default.
• W4282024710 cites W2777639606 @default.
• W4282024710 cites W2782326402 @default.
• W4282024710 cites W2791456551 @default.
• W4282024710 cites W2794458614 @default.
• W4282024710 cites W2794480084 @default.
• W4282024710 cites W2811205482 @default.
• W4282024710 cites W2817838603 @default.
• W4282024710 cites W2896352133 @default.
• W4282024710 cites W2897748644 @default.
• W4282024710 cites W2942008693 @default.
• W4282024710 cites W2944545583 @default.
• W4282024710 cites W2949177718 @default.
• W4282024710 cites W2950637038 @default.
• W4282024710 cites W2950885009 @default.
• W4282024710 cites W2951506174 @default.
• W4282024710 cites W2966343091 @default.
• W4282024710 cites W2969870849 @default.
• W4282024710 cites W2970346229 @default.
• W4282024710 cites W2981477552 @default.
• W4282024710 cites W2990611031 @default.
• W4282024710 cites W2998840182 @default.
• W4282024710 cites W3010054644 @default.
• W4282024710 cites W3014260633 @default.
• W4282024710 cites W3023290106 @default.
• W4282024710 cites W3025047014 @default.
• W4282024710 cites W3038245585 @default.
• W4282024710 cites W3041479264 @default.
• W4282024710 cites W3048149017 @default.
• W4282024710 cites W3158914043 @default.
• W4282024710 cites W3164655551 @default.
• W4282024710 cites W3165246254 @default.
• W4282024710 cites W3197364483 @default.
• W4282024710 cites W3202159881 @default.
• W4282024710 cites W3211534834 @default.
• W4282024710 cites W4213108508 @default.
• W4282024710 cites W4223992851 @default.
• W4282024710 cites W4225287808 @default.
• W4282024710 cites W4245522537 @default.
• W4282024710 cites W4280521461 @default.

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