FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282025061> ?p ?o ?g. }

• W4282025061 abstract "Introduction Antidepressants are the front-line treatments for major depressive disorder (MDD), but remain unsatisfactory in outcome. An increasing number of patients are interested in acupuncture and moxibustion treatment as complementary therapies. This study aims to evaluate the efficacy and safety of integrative acupuncture and moxibustion (iAM) treatment in patients with MDD. Methods and Analysis This multicenter, single-blind, 2 × 2 factorial randomized trial will enroll 592 patients with MDD of moderate severity from nine hospitals. All patients will be randomized, in a ratio of 2:2:2:1, through a computerized central randomization system, into four groups (the combined, iAM-only, sertraline-only, and placebo groups). Participants will undergo a 12-week intervention with either 50 mg of sertraline or a placebo once a day and active/sham iAM treatment three times per week. The primary outcome is depression severity, assessed using the Hamilton Depression Scale-17. The secondary outcomes include self-rated depression severity, anxiety, and sleep quality. The primary and secondary outcomes will be measured at weeks 0, 4, 8, 12, and the 8th week posttreatment. Safety will be evaluated through liver and kidney function tests conducted before and after treatment and through monitoring of daily adverse events. An intent-to-treat principle will be followed for the outcome analyses. Conclusion This trial will provide sufficient evidence to ascertain whether iAM is effective and safe for treating MDD and provides a suitable combination strategy for treating MDD. Clinical Trial Registration [ www.chictr.org.cn ], identifier [ChiCTR2100042841]." @default.
• W4282025061 created "2022-06-13" @default.
• W4282025061 creator A5006902723 @default.
• W4282025061 creator A5028713964 @default.
• W4282025061 creator A5031767581 @default.
• W4282025061 creator A5032437498 @default.
• W4282025061 creator A5033680880 @default.
• W4282025061 creator A5039595617 @default.
• W4282025061 creator A5041247351 @default.
• W4282025061 creator A5044503038 @default.
• W4282025061 creator A5048225041 @default.
• W4282025061 creator A5053236113 @default.
• W4282025061 creator A5062243959 @default.
• W4282025061 creator A5064758793 @default.
• W4282025061 creator A5065058975 @default.
• W4282025061 creator A5066068204 @default.
• W4282025061 creator A5069299119 @default.
• W4282025061 creator A5084657803 @default.
• W4282025061 creator A5085663161 @default.
• W4282025061 creator A5087528936 @default.
• W4282025061 date "2022-05-30" @default.
• W4282025061 modified "2023-09-30" @default.
• W4282025061 title "Efficacy of the Integrative Acupuncture and Moxibustion Treatment in Patients With Major Depressive Disorder: The Study Protocol for a Multicenter, Single-Blinded, Randomized Trial in China" @default.
• W4282025061 cites W1480729244 @default.
• W4282025061 cites W1988190900 @default.
• W4282025061 cites W1995485235 @default.
• W4282025061 cites W2001832928 @default.
• W4282025061 cites W2006637458 @default.
• W4282025061 cites W2019068493 @default.
• W4282025061 cites W2021572813 @default.
• W4282025061 cites W2032291013 @default.
• W4282025061 cites W2032541700 @default.
• W4282025061 cites W2042020035 @default.
• W4282025061 cites W2054931962 @default.
• W4282025061 cites W2055974480 @default.
• W4282025061 cites W2070828096 @default.
• W4282025061 cites W2075107167 @default.
• W4282025061 cites W2107684767 @default.
• W4282025061 cites W2114613490 @default.
• W4282025061 cites W2132227441 @default.
• W4282025061 cites W2132322340 @default.
• W4282025061 cites W2134254973 @default.
• W4282025061 cites W2135558708 @default.
• W4282025061 cites W2137229142 @default.
• W4282025061 cites W2143892561 @default.
• W4282025061 cites W2145697333 @default.
• W4282025061 cites W2151487996 @default.
• W4282025061 cites W2154690800 @default.
• W4282025061 cites W2156782268 @default.
• W4282025061 cites W2166023752 @default.
• W4282025061 cites W2188745380 @default.
• W4282025061 cites W2290565400 @default.
• W4282025061 cites W2412355634 @default.
• W4282025061 cites W2463496270 @default.
• W4282025061 cites W2756376025 @default.
• W4282025061 cites W2788337440 @default.
• W4282025061 cites W2800356151 @default.
• W4282025061 cites W2899591457 @default.
• W4282025061 cites W2926046275 @default.
• W4282025061 cites W2941307081 @default.
• W4282025061 cites W2981452097 @default.
• W4282025061 cites W3080161023 @default.
• W4282025061 cites W3095689469 @default.
• W4282025061 cites W3127424424 @default.
• W4282025061 cites W3159270173 @default.
• W4282025061 cites W3195907678 @default.
• W4282025061 doi "https://doi.org/10.3389/fmed.2022.761419" @default.
• W4282025061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35707522" @default.
• W4282025061 hasPublicationYear "2022" @default.
• W4282025061 type Work @default.
• W4282025061 citedByCount "0" @default.
• W4282025061 crossrefType "journal-article" @default.
• W4282025061 hasAuthorship W4282025061A5006902723 @default.
• W4282025061 hasAuthorship W4282025061A5028713964 @default.
• W4282025061 hasAuthorship W4282025061A5031767581 @default.
• W4282025061 hasAuthorship W4282025061A5032437498 @default.
• W4282025061 hasAuthorship W4282025061A5033680880 @default.
• W4282025061 hasAuthorship W4282025061A5039595617 @default.
• W4282025061 hasAuthorship W4282025061A5041247351 @default.
• W4282025061 hasAuthorship W4282025061A5044503038 @default.
• W4282025061 hasAuthorship W4282025061A5048225041 @default.
• W4282025061 hasAuthorship W4282025061A5053236113 @default.
• W4282025061 hasAuthorship W4282025061A5062243959 @default.
• W4282025061 hasAuthorship W4282025061A5064758793 @default.
• W4282025061 hasAuthorship W4282025061A5065058975 @default.
• W4282025061 hasAuthorship W4282025061A5066068204 @default.
• W4282025061 hasAuthorship W4282025061A5069299119 @default.
• W4282025061 hasAuthorship W4282025061A5084657803 @default.
• W4282025061 hasAuthorship W4282025061A5085663161 @default.
• W4282025061 hasAuthorship W4282025061A5087528936 @default.
• W4282025061 hasBestOaLocation W42820250611 @default.
• W4282025061 hasConcept C118552586 @default.
• W4282025061 hasConcept C126322002 @default.
• W4282025061 hasConcept C139719470 @default.
• W4282025061 hasConcept C142724271 @default.
• W4282025061 hasConcept C162324750 @default.
• W4282025061 hasConcept C168563851 @default.
• W4282025061 hasConcept C1862650 @default.
• W4282025061 hasConcept C197934379 @default.
• W4282025061 hasConcept C204243189 @default.

• next