Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282025463> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4282025463 endingPage "A48" @default.
- W4282025463 startingPage "A48.1" @default.
- W4282025463 abstract "Background Whilst current diagnostic criteria for primary progressive aphasia syndromes (PPA) emphasise impaired language output and linguistic processing, deficits of auditory analysis are increasingly rec- ognised in PPA syndromes. We assessed phonemic discrimination and its neuroanatomical correlates in patients representing all major PPA variants, compared with typical Alzheimer’s disease (tAD) and healthy age-matched individuals. Methods 81 patients with PPA or typical Alzheimer’s disease, and 73 controls performed a phonemic minimal pair discrimination task. Neuroanatomical associations of phonemic discrimination performance across the PPA cohort were assessed using voxel-based morphometry. Results Patients with logopoenic variant primary progressive aphasia (lvPPA) as a group performed sig- nificantly worse than both the healthy control group and other PPA variants, after adjusting for auditory verbal working memory. Patients with typical Alzheimer’s disease showed a similar pattern of performance to the lvPPA group. Voxel-based morphometry revealed a significant association of regional grey matter in left angular gyrus with phonemic discrimination performance. Conclusions Impaired phonemic discrimination is a component of lvPPA and may help differentiate this syndrome from other forms of PPA. These findings speak to the emerging theme of auditory perceptual dysfunction in the progressive aphasias, with implications both for refining diagnostic criteria and developing new clinical biomarkers. jeremy.johnson@doctors.org.uk" @default.
- W4282025463 created "2022-06-13" @default.
- W4282025463 creator A5006229535 @default.
- W4282025463 creator A5018933606 @default.
- W4282025463 creator A5066792343 @default.
- W4282025463 creator A5068675261 @default.
- W4282025463 creator A5069154996 @default.
- W4282025463 creator A5069523262 @default.
- W4282025463 creator A5070348432 @default.
- W4282025463 creator A5070660863 @default.
- W4282025463 creator A5081173934 @default.
- W4282025463 creator A5081470647 @default.
- W4282025463 date "2022-05-27" @default.
- W4282025463 modified "2023-09-27" @default.
- W4282025463 title "120 Impaired phonemic discrimination in logopenic variant primary progressive aphasia" @default.
- W4282025463 doi "https://doi.org/10.1136/jnnp-2022-abn.153" @default.
- W4282025463 hasPublicationYear "2022" @default.
- W4282025463 type Work @default.
- W4282025463 citedByCount "0" @default.
- W4282025463 crossrefType "journal-article" @default.
- W4282025463 hasAuthorship W4282025463A5006229535 @default.
- W4282025463 hasAuthorship W4282025463A5018933606 @default.
- W4282025463 hasAuthorship W4282025463A5066792343 @default.
- W4282025463 hasAuthorship W4282025463A5068675261 @default.
- W4282025463 hasAuthorship W4282025463A5069154996 @default.
- W4282025463 hasAuthorship W4282025463A5069523262 @default.
- W4282025463 hasAuthorship W4282025463A5070348432 @default.
- W4282025463 hasAuthorship W4282025463A5070660863 @default.
- W4282025463 hasAuthorship W4282025463A5081173934 @default.
- W4282025463 hasAuthorship W4282025463A5081470647 @default.
- W4282025463 hasBestOaLocation W42820254632 @default.
- W4282025463 hasConcept C126838900 @default.
- W4282025463 hasConcept C142724271 @default.
- W4282025463 hasConcept C143409427 @default.
- W4282025463 hasConcept C15744967 @default.
- W4282025463 hasConcept C169760540 @default.
- W4282025463 hasConcept C200134340 @default.
- W4282025463 hasConcept C2776228812 @default.
- W4282025463 hasConcept C2778641062 @default.
- W4282025463 hasConcept C2779134260 @default.
- W4282025463 hasConcept C2779140760 @default.
- W4282025463 hasConcept C2779422653 @default.
- W4282025463 hasConcept C2779483572 @default.
- W4282025463 hasConcept C2781192897 @default.
- W4282025463 hasConcept C548259974 @default.
- W4282025463 hasConcept C71924100 @default.
- W4282025463 hasConcept C94445187 @default.
- W4282025463 hasConceptScore W4282025463C126838900 @default.
- W4282025463 hasConceptScore W4282025463C142724271 @default.
- W4282025463 hasConceptScore W4282025463C143409427 @default.
- W4282025463 hasConceptScore W4282025463C15744967 @default.
- W4282025463 hasConceptScore W4282025463C169760540 @default.
- W4282025463 hasConceptScore W4282025463C200134340 @default.
- W4282025463 hasConceptScore W4282025463C2776228812 @default.
- W4282025463 hasConceptScore W4282025463C2778641062 @default.
- W4282025463 hasConceptScore W4282025463C2779134260 @default.
- W4282025463 hasConceptScore W4282025463C2779140760 @default.
- W4282025463 hasConceptScore W4282025463C2779422653 @default.
- W4282025463 hasConceptScore W4282025463C2779483572 @default.
- W4282025463 hasConceptScore W4282025463C2781192897 @default.
- W4282025463 hasConceptScore W4282025463C548259974 @default.
- W4282025463 hasConceptScore W4282025463C71924100 @default.
- W4282025463 hasConceptScore W4282025463C94445187 @default.
- W4282025463 hasIssue "6" @default.
- W4282025463 hasLocation W42820254631 @default.
- W4282025463 hasLocation W42820254632 @default.
- W4282025463 hasLocation W42820254633 @default.
- W4282025463 hasOpenAccess W4282025463 @default.
- W4282025463 hasPrimaryLocation W42820254631 @default.
- W4282025463 hasRelatedWork W1969728453 @default.
- W4282025463 hasRelatedWork W2039802108 @default.
- W4282025463 hasRelatedWork W2070668675 @default.
- W4282025463 hasRelatedWork W2093880677 @default.
- W4282025463 hasRelatedWork W2501392088 @default.
- W4282025463 hasRelatedWork W2567691650 @default.
- W4282025463 hasRelatedWork W2775293277 @default.
- W4282025463 hasRelatedWork W3174439744 @default.
- W4282025463 hasRelatedWork W4282025463 @default.
- W4282025463 hasRelatedWork W4308594729 @default.
- W4282025463 hasVolume "93" @default.
- W4282025463 isParatext "false" @default.
- W4282025463 isRetracted "false" @default.
- W4282025463 workType "article" @default.